Does cerebral blood flow decline in healthy aging? A PET study with partial-volume correction.

“Mini-mental state”

1975 • 82,784 citations

MRI-PET Registration with Automated Algorithm

1993 • 1,654 citations

CEREBRAL BLOOD FLOW, BLOOD VOLUME AND OXYGEN UTILIZATION

1990 • 1,044 citations

Age-Related Reductions in Human Recognition Memory Due to Impaired Encoding

1995 • 650 citations

A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: Implications for theories of executive functioning and cognitive aging

1998 • 588 citations

Sex Differences in Human Brain Morphometry and Metabolism: An In Vivo Quantitative Magnetic Resonance Imaging and Positron Emission Tomography Study on the Effect of Aging

1996 • 533 citations

Decreases in Regional Cerebral Blood Flow with Normal Aging

1991 • 400 citations

Regional cerebral blood flow and oxygen consumption in human aging.

1984 • 338 citations

Correction of PET Data for Partial Volume Effects in Human Cerebral Cortex by MR Imaging

1990 • 327 citations

Cerebral blood flow changes in benign aging and cerebrovascular disease

1984 • 316 citations

Individual differences in the cognitive and neurobiological consequences of normal aging

1992 • 287 citations

Reduction in regional cerebral blood flow during normal aging in man.

1980 • 280 citations

Surface-based labeling of cortical anatomy using a deformable atlas

1997 • 277 citations

Regional Cerebral Oxygen Consumption, Blood Flow, and Blood Volume in Healthy Human Aging

1992 • 268 citations

Reduction in regional cerebral metabolic rate of oxygen during human aging.

1986 • 260 citations

Comparative evaluation of MR-based partial-volume correction schemes for PET.

1999 • 251 citations

Sulcal, ventricular, and white matter changes at MR imaging in the aging brain: data from the cardiovascular health study.

1997 • 238 citations

Regional cerebral function determined by FDG-PET in healthy volunteers: normal patterns and changes with age.

1995 • 219 citations

Age and Regional Cerebral Blood Flow at Rest and During Cognitive Activity

1987 • 204 citations

Quantitative Measurement of Local Cerebral Blood Flow in Humans by Positron Computed Tomography and ¹⁵O-Water

1983 • 194 citations

Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging

1996 • 178 citations

Age-related Reduction in Functional MRI Response to Photic Stimulation

1997 • 174 citations

Sensitivity of Cerebral Glucose Metabolism to Age, Gender, Brain Volume, Brain Atrophy, and Cerebrovascular Risk Factors

1988 • 168 citations

Cerebral blood flow and cerebrovascular CO ₂ reactivity in stroke‐age normal controls

1983 • 161 citations

Cerebral [¹⁵O]Water Clearance in Humans Determined by PET: I. Theory and Normal Values

1996 • 151 citations

Analysis of brain and cerebrospinal fluid volumes with MR imaging: impact on PET data correction for atrophy. Part II. Aging and Alzheimer dementia.

1991 • 148 citations

Quantitative analysis of PET and MRI data in normal aging and Alzheimer's disease: atrophy weighted total brain metabolism and absolute whole brain metabolism as reliable discriminators.

1993 • 139 citations

Reduced binding of [18F]altanserin to serotonin type 2A receptors in aging: persistence of effect after partial volume correction

1998 • 127 citations

Comparison of CT, MR, and PET in Alzheimer's dementia and normal aging.

1989 • 125 citations

Absolute number of neurons and thickness of the cerebral cortex during aging, senile and vascular dementia, and Pick's and Alzheimer's diseases

1973 • 123 citations

Regional cerebral blood flow, blood volume, oxygen extraction fraction, and oxygen utilization rate in normal volunteers measured by the autoradiographic technique and the single breath inhalation method

1995 • 115 citations

Age-related decline of cerebral oxygen metabolism in normal population detected with positron emission tomography

1992 • 83 citations

Positron emission tomography studies of normal aging: A replication of PET III and 18-FDG using PET VI and 11-CDG

1987 • 76 citations

Stability of Cerebral Blood Flow and Oxygen Metabolism during Normal Aging

1990 • 49 citations

Use of singular value decomposition to characterize age and gender differences in SPECT cerebral perfusion.

1998 • 45 citations

Accuracy of ventricular volume estimation.

1979 • 43 citations

Association of Age with Regional Cerebral Oxygen Utilization: A Positron Emission Tomography Study

1992 • 24 citations

Effect of Aging on Regulation of Brain Stem Circulation During Hypotension

1997 • 21 citations

Changing Topographic Patterns of Human Cerebral Blood Flow with Age Measured by Xenon CT

1984 • 13 citations