Can Only Partial T-Cell Depletion of the Graft before Hematopoietic Stem Cell Transplantation Mitigate Graft-versus-Host Disease While Preserving a Graft-versus-Leukemia Reaction? A Prospective Phase II Study

Nonparametric Estimation from Incomplete Observations

1992 • 45,923 citations

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Efficacy and Safety of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in Chronic Myeloid Leukemia

2001 • 5,189 citations

CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S

1974 • 3,686 citations

Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia [see comments]

1995 • 2,026 citations

Methotrexate and Cyclosporine Compared with Cyclosporine Alone for Prophylaxis of Acute Graft versus Host Disease after Marrow Transplantation for Leukemia

1986 • 1,453 citations

Transplantation of Bone Marrow as Compared with Peripheral-Blood Cells from HLA-Identical Relatives in Patients with Hematologic Cancers

2001 • 981 citations

Bone Marrow Transplantation for Chronic Myelogenous Leukemia in Chronic Phase

1988 • 887 citations

Regimen-related toxicity in patients undergoing bone marrow transplantation.

1988 • 876 citations

Transplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony-stimulating factor [see comments]

1995 • 616 citations

Bone Marrow Transplantation

1994 • 597 citations

Allogeneic blood stem cell transplantation for refractory leukemia and lymphoma: potential advantage of blood over marrow allografts [see comments]

1995 • 557 citations

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation

2000 • 525 citations

Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens [see comments]

1990 • 525 citations

Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts

1985 • 517 citations

Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation

2000 • 515 citations

Primary transplantation of allogeneic peripheral blood progenitor cells mobilized by filgrastim (granulocyte colony-stimulating factor) [see comments]

1995 • 508 citations

Polymerase chain reaction monitoring reduces the incidence of cytomegalovirus disease and the duration and side effects of antiviral therapy after bone marrow transplantation

1995 • 469 citations

Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens [see comments]

1990 • 446 citations

ELIMINATION OF GRAFT-VERSUS-HOST DISEASE BY IN-VITRO DEPLETION OF ALLOREACTIVE LYMPHOCYTES WITH A MONOCLONAL RAT ANTI-HUMAN LYMPHOCYTE ANTIBODY (CAMPATH-1)

1984 • 436 citations

Randomized Trial of Bone Marrow Versus Lenograstim-Primed Blood Cell Allogeneic Transplantation in Patients With Early-Stage Leukemia: A Report From the Société Française de Greffe de Moelle

2000 • 391 citations

Allogeneic bone marrow transplantation versus autologous stem cell transplantation in multiple myeloma: a retrospective case-matched study from the European Group for Blood and Marrow Transplantation

1996 • 376 citations

Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease

1986 • 374 citations

Allogeneic peripheral blood stem cell transplantation in patients with advanced hematologic malignancies: a retrospective comparison with marrow transplantation

1996 • 370 citations

Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases: a randomised trial

2000 • 365 citations

DEPLETION OF T LYMPHOCYTES IN DONOR MARROW PREVENTS SIGNIFICANT GRAFT-VERSUS-HOST DISEASE IN MATCHED ALLOGENEIC LEUKAEMIC MARROW TRANSPLANT RECIPIENTS

1984 • 362 citations

Graft-versus-Host Disease as Adoptive Immunotherapy in Patients with Advanced Hematologic Neoplasms

1989 • 361 citations

Salvage immunotherapy using donor leukocyte infusions as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation: efficacy and toxicity of a defined T-cell dose

1993 • 356 citations

Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?

2001 • 347 citations

A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group

1994 • 341 citations

A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies

2002 • 338 citations

Allogeneic marrow transplantation in patients with chronic myeloid leukemia in the chronic phase: a randomized trial of two irradiation regimens

1991 • 335 citations

Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia

1994 • 296 citations

Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia: first results of a randomised multicentre trial of the European Group for Blood and Marrow Transplantation

1998 • 276 citations

Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia

2002 • 270 citations

Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia

1994 • 264 citations

Allogeneic bone marrow transplantation for 93 patients with myelodysplastic syndrome

1993 • 218 citations

Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection

1998 • 207 citations

Graft failure in patients receiving T cell-depleted HLA-identical allogeneic marrow transplants.

1988 • 195 citations

Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial [see comments]

1992 • 190 citations

Pharmacokinetics of alemtuzumab used for in vivo and in vitro T-cell depletion in allogeneic transplantations: relevance for early adoptive immunotherapy and infectious complications

2003 • 190 citations

T CELL DEPLETION WITH CAMPATH-1 IN ALLOGENEIC BONE MARROW TRANSPLANTATION

1988 • 189 citations

T-cell-depleted allogeneic bone marrow transplantation for acute leukaemia using Campath-1 antibodies and post-transplant administration of donor's peripheral blood lymphocytes for prevention of relapse

1995 • 167 citations

Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: a prospective, randomized trial [see comments]

1992 • 163 citations

T cell-depleted bone marrow transplantation and delayed T cell add-back to control acute GVHD and conserve a graft-versus-leukemia effect

1998 • 159 citations

Transplantation of Peripheral Blood Stem Cells as Compared With Bone Marrow From HLA-Identical Siblings in Adult Patients With Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia

2002 • 156 citations

Contribution of CD4+ and CD8+ T cells to graft-versus-host disease and graft-versus-leukemia reactivity after transplantation of MHC-compatible bone marrow.

1991 • 154 citations

Delayed infusion of immunocompetent donor cells after bone marrow transplantation breaks graft-host tolerance allows for persistent antileukemic reactivity without severe graft-versus-host disease

1995 • 137 citations

What role for prednisone in prevention of acute graft-versus-host disease in patients undergoing marrow transplants?

1990 • 129 citations

Prevention of veno-occlusive disease with defibrotide after allogeneic stem cell transplantation

2004 • 127 citations

Comparative Outcomes of T-Cell–Depleted and Non–T-Cell–Depleted Allogeneic Bone Marrow Transplantation for Chronic Myelogenous Leukemia: Impact of Donor Lymphocyte Infusion

1999 • 118 citations

CD6-Depleted Allogeneic Bone Marrow Transplantation for Acute Leukemia in First Complete Remission

1997 • 96 citations

Allogeneic bone marrow transplantation with a fixed low number of T cells in the marrow graft [see comments]

1994 • 93 citations

Adoptive immunotherapy using donor leukocytes following bone marrow transplantation for chronic myeloid leukemia: is T cell dose important in determining biological response?

1995 • 86 citations

Total body irradiation before allogeneic bone marrow transplantation: is more dose better?

2001 • 63 citations

Induction of graft-versus-leukemia to prevent relapse after partially lymphocyte-depleted allogeneic bone marrow transplantation by pre-emptive donor leukocyte infusions

2001 • 62 citations

GRAFT-VERSUS-MYELOID LEUKEMIA RESPONSES FOLLOWING SYNGENEIC AND ALLOGENEIC BONE MARROW TRANSPLANTATION

1994 • 61 citations

T-cell depletion with Campath-1H ‘in the bag’ for matched related allogeneic peripheral blood stem cell transplantation is associated with reduced graft-versus-host disease, rapid immune constitution and improved survival

2003 • 60 citations

A randomized multicenter comparison of CD34+-selected progenitor cells from blood vs from bone marrow in recipients of HLA-identical allogeneic transplants for hematological malignancies

2003 • 57 citations

Autologous bone marrow transplantation for acute myeloid leukemia in first remission: identification of modifiable prognostic factors.

1995 • 55 citations

Bone marrow transplantation for primary refractory acute leukaemia.

1994 • 47 citations

In the bag.

2001 • 41 citations

Comparison of allogeneic T cell-depleted peripheral blood stem cell and bone marrow transplantation: effect of stem cell source on short- and long-term outcome

2001 • 31 citations

The role of CD4 and CD8 T cells in the graft-versus-leukemia response in Rauscher murine leukemia.

1991 • 30 citations

Engraftment of marrow allografts treated with Campath-1 monoclonal antibodies

1999 • 27 citations

Elimination of Graft Versus Host Disease in Matched Allogeneic Leukemic Transplant Recipients Using Campath-1

1985 • 10 citations