Cyclophosphamide-Induced Immunological Tolerance: an Overview

T cell tolerance by clonal elimination in the thymus

1987 • 2,248 citations

Cell migration, chimerism, and graft acceptance

1992 • 1,075 citations

Self-tolerance eliminates T cells specific for Mls-modified products of the major histocompatibility complex

1988 • 1,036 citations

T-cell receptor Vβ use predicts reactivity and tolerance to Mlsa- encoded antigens

1988 • 901 citations

Drug-induced Immunological Tolerance

1959 • 480 citations

Present experiences in a series of 26 ABO-incompatible living donor renal allografts.

1987 • 330 citations

THE REJECTION OF RENAL HOMOGRAFTS

1960 • 312 citations

Differential Effects of Cyclophosphamide on the B and T Cell Compartments of Adult Mice

1973 • 290 citations

Chimerism after Liver Transplantation for Type IV Glycogen Storage Disease and Type 1 Gaucher's Disease

1993 • 258 citations

SOUR MILK AND THE TUBERCLE BACILLUS

1946 • 224 citations

SEPARATION OF MALARIA-INFECTED ERYTHROCYTES FROM WHOLE BLOOD: USE OF A SELECTIVE HIGH-GRADIENT MAGNETIC SEPARATION TECHNIQUE

1981 • 219 citations

CELL POPULATIONS AND CELL PROLIFERATION IN THE IN VITRO RESPONSE OF NORMAL MOUSE SPLEEN TO HETEROLOGOUS ERYTHROCYTES

1967 • 218 citations

HAMSTER-TO-RAT HEART AND LIVER XENOTRANSPLANTATION WITH FK506 PLUS ANTIPROLIFERATIVE DRUGS

1993 • 155 citations

Long-lasting skin allograft tolerance in adult mice induced across fully allogeneic (multimajor H-2 plus multiminor histocompatibility) antigen barriers by a tolerance-inducing method using cyclophosphamide.

1989 • 154 citations

Prolongation of Homograft Survival in Mice with Single Doses of Cyclophosphamide

1963 • 136 citations

STUDIES ON CYCLOPHOSPHAMIDE-INDUCED TOLERANCE TO SHEEP ERYTHROCYTES

1967 • 121 citations

Intrathymic elimination of Mlsa-reactive (V beta 6+) cells during neonatal tolerance induction to Mlsa-encoded antigens.

1988 • 117 citations

Intrathymic clonal deletion of V beta 6+ T cells in cyclophosphamide-induced tolerance to H-2-compatible, Mls-disparate antigens.

1990 • 106 citations

Mechanisms of Immunosuppression: Effects of Cyclophosphamide on Cellular Immunity

1973 • 88 citations

DRUG-INDUCED TOLERANCE TO ALLOGRAFTS IN MICE

1984 • 86 citations

Specific destruction of host-reactive mature T cells of donor origin prevents graft-versus-host disease in cyclophosphamide-induced tolerant mice.

1991 • 76 citations

Sequential mechanisms of cyclophosphamide-induced skin allograft tolerance including the intrathymic clonal deletion followed by late breakdown of the clonal deletion.

1990 • 75 citations

Importance of suppressor T cells in cyclophosphamide-induced tolerance to the non-H-2-encoded alloantigens. Is mixed chimerism really required in maintaining a skin allograft tolerance?

1990 • 75 citations

CYCLOPHOSPHAMIDE AND HUMAN ORGAN TRANSPLANTATION

1971 • 69 citations

Evidence for involvement of clonal anergy in MHC class I and class II disparate skin allograft tolerance after the termination of intrathymic clonal deletion.

1990 • 66 citations

Specificity of Antigen Recognition by Human Lymphocytes in vitro

1970 • 65 citations

Lymphocyte Stimulation: Selective Destruction of Cells during Blastogenic Response to Transplantation Antigens

1971 • 57 citations

DRUG-INDUCED IMMUNOLOGICAL “TOLERANCE” FOR HOMO-TRANSPLANTATION

1961 • 53 citations

Interference with cyclophosphamide-induced skin allograft tolerance by cyclosporin A.

1992 • 51 citations

A COMPARISON OF THE EFFECTS OF SELECTED CYTOTOXIC AGENTS ON ALLOGENEIC SKIN GRAFT SURVIVAL IN RATS.

1965 • 50 citations

SUPPRESSION OF TISSUE IMMUNITY BY CYCLOPHOSPHAMIDE

1964 • 49 citations

ALTERATION OF THE HOMOGRAFT RESPONSE BY ANTIMETABOLITES *

1960 • 48 citations

Inhibition of the Inductive Phase of Antibody Formation by 6-Mercaptopurine examined by the Transfer of Isolated Cells

1960 • 47 citations

The requirement of intrathymic mixed chimerism and clonal deletion for a long‐lasting skin allograft tolerance in cyclophosphamide‐induced tolerance

1990 • 35 citations

Role of peripheral hemopoietic chimerism in achieving donor-specific tolerance in adult mice.

1993 • 34 citations

EFFECT OF SPLENECTOMY ON HUMAN RENAL TRANSPLANTS

1973 • 32 citations

Specific immune tolerance to anaphylactic sensitization (egg albumin) induced in the guinea pig by cyclophosphoramide (Cytoxan)

1961 • 31 citations

DRUG-INDUCED TOLERANCE TO ALLOGRAFTS IN MICE

1986 • 31 citations

Curative Potencies against α-Amanitin Poisoning by Cytochrome c

1972 • 26 citations

The Necessity of Both Allogeneic Antigens and Stem Cells for Cyclophosphamide-Induced Skin Allograft Tolerance in Mice

1989 • 25 citations

Direct evidence for clonal destruction of allo-reactive T cells in the mice treated with cyclophosphamide after allo-priming.

1993 • 25 citations

The Induction and Abolition of Specific Immunosuppression of Heart Allografts in Rats by Use of Donor Blood and Cyclophosphamide

1975 • 22 citations

INDUCTION OF TOLERANCE TO SKIN HOMOGRAFTS IN ADULT MICE TREATED WITH 6-MERCAPTOPURINE

1961 • 21 citations

Prevention of Cyclophosphamide-Induced Tolerance to Erythrocytes by Pretreatment with Cortisone

1970 • 21 citations

SPECIFIC UNRESPONSIVENESS TO SKIN ALLOGRAFTS IN MICE

1974 • 18 citations

6-Mercaptopurine in Immunological Responsiveness

1960 • 17 citations

MECHANISMS OF CYCLOPHOSPHAMIDE-INDUCED TOLERANCE TO IE-ENCODED ALLOANTIGENS—EVIDENCE OF CLONAL DELETION IN MHC ANTIGEN-REACTIVE CELLS FOR SKIN ALLOGRAFT REJECTION

1992 • 17 citations

Drug Effects on Survival of Homografts of Skins

1963 • 15 citations

IMMUNOLOGICAL STATUS OF MICE WITH LONG-STANDING ALLOGENEIC OR XENOGENEIC NEONATAL HEART GRAFTS

1984 • 14 citations

DRUG-INDUCED TOLERANCE TO ALLOGRAFTS IN MICE

1985 • 14 citations

Cyclophosphamide-induced immunologic tolerance to skin homografts.

1971 • 13 citations

Cyclophosphamide-induced chimera-type tolerance to allografts: an overview of drug-induced immunological tolerance.

1990 • 13 citations

Induction of Tolerance across Major Barriers Using a Two-Step Method with Genetic Analysis of Tolerance Induction

1989 • 11 citations

Recombinant human granulocyte colony-stimulating factor improves the compromised state of recipient mice without affecting the induction of specific tolerance in the cyclophosphamide-induced tolerance system.

1991 • 11 citations

Similarity and difference in the mechanisms of neonatally induced tolerance and cyclophosphamide-induced tolerance in mice.

1991 • 9 citations

DRUG-INDUCED IN VITRO TOLERANCE TO ALLOGENEIC ANTIGENS

1988 • 9 citations

A NEW STRATEGY FOR PROLONGING XENOGRAFT SURVIVAL1

1994 • 8 citations

Cyclophosphamide-Induced Tolerance in Fully Allogeneic Heart Transplantation in Mice

1994 • 7 citations

Recent advances in hepatic transplantation at the University of Pittsburgh.

1993 • 5 citations

Effects of Chronic Cyclophosphamide and Methotrexate Treatment on Skin Allograft Survival in Mice and Rats 2

1973 • 5 citations

Letters to the Editor

1991 • 3 citations

Prolongation of skin graft survival in mice by pretreatment with H-2 antigen and cyclophosphamide.

1970 • 3 citations

Xenogeneic (rat to mouse) skin tolerance induced by monoclonal antibodies, xenogeneic cells, and cyclophosphamide.

1995 • 2 citations

A MAJOR DIFFERENCE IN THE MECHANISMS OF NEONATALLY INDUCED TOLERANCE AND CYCLOPHOSPHAMIDE-INDUCED TOLERANCE

1992 • 1 citations

Prolonged chimerism of lymphoid tissue obtained from adult mice with the aid of cyclophosphamide

1971 • 1 citations