The distribution of MUC1, an apical membrane glycoprotein, in mammary epithelial cells at the resolution of the electron microscope: implications for the mechanism of milk secretion

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

A rapid, sensitive method for detection of alkaline phosphatase-conjugated anti-antibody on Western blots

1984 • 2,189 citations

Constitutive and Regulated Secretion of Proteins

1987 • 1,021 citations

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.

1990 • 994 citations

Sorting and storage during secretory granule biogenesis: looking backward and looking forward

1998 • 516 citations

Monoclonal antibodies against human milk‐fat globule membranes detecting differentiation antigens of the mammary gland and its tumors

1984 • 510 citations

A Review and Proposed Nomenclature for Major Proteins of the Milk-Fat Globule Membrane,

2000 • 405 citations

Mechanism of milk secretion

1971 • 401 citations

Membrane traffic in polarized epithelial cells

2000 • 384 citations

Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini.

1990 • 376 citations

Post-Golgi biosynthetic trafficking

1997 • 373 citations

Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

1996 • 354 citations

Origin and secretion of milk lipids.

1998 • 342 citations

Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers

1981 • 331 citations

The epithelial mucin, MUC1, of milk, mammary gland and other tissues

1995 • 285 citations

�ber die Morphologie der Milchsekretion Licht- und elektronenmikroskopische Studien an der Milchdr�se der Ratte

1959 • 267 citations

Simultaneous glutaraldehyde-osmium tetroxide fixation with postosmication

1969 • 266 citations

Involvement of vesicle coat material in casein secretion and surface regeneration.

1976 • 256 citations

Human epithelial tumor antigen cDNA sequences

1990 • 242 citations

Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism

1991 • 225 citations

Proteomics reveal a link between the endoplasmic reticulum and lipid secretory mechanisms in mammary epithelial cells

2000 • 212 citations

Two rapid and simple methods used for the removal of resins from 1.0 μm thick epoxy sections

1978 • 201 citations

Clathrin-mediated Endocytosis of MUC1 Is Modulated by Its Glycosylation State

2000 • 180 citations

The mechanism of secretion of the milk fat globule

1971 • 171 citations

Comparison of the phospholipid composition of breast milk from mothers of term and preterm infants during lactation

1984 • 159 citations

The epithelial sialomucin, episialin, is sialylated during recycling.

1993 • 148 citations

Biosynthesis of MAM-6, an epithelial sialomucin. Evidence for involvement of a rare proteolytic cleavage step in the endoplasmic reticulum.

1988 • 142 citations

Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development

1992 • 119 citations

Apical targeting in polarized epithelial cells: There's more afloat than rafts

1997 • 118 citations

MUC1 Glycoforms in Breast Cancer

1996 • 111 citations

Vesicular stomatitis virus glycoprotein, albumin, and transferrin are transported to the cell surface via the same Golgi vesicles.

1983 • 107 citations

Determination of apical membrane polarity in mammary epithelial cell cultures: The role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions

1990 • 102 citations

Membrane and secretory proteins are transported from the Golgi complex to the sinusoidal plasmalemma of hepatocytes by distinct vesicular carriers.

1994 • 95 citations

Distinct pathways for basolateral targeting of membrane and secretory proteins in polarized epithelial cells.

1991 • 91 citations

Proteins are secreted by both constitutive and regulated secretory pathways in lactating mouse mammary epithelial cells

1992 • 90 citations

The role of the plasma membrane in the secretion of milk fat

1967 • 90 citations

Exocytic transport vesicles generated in vitro from the trans-Golgi network carry secretory and plasma membrane proteins.

1990 • 85 citations

Transport of casein submicelles and formation of secretion granules in the golgi apparatus of epithelial cells of the lactating mammary gland of the rat

1993 • 80 citations

Inhibition of constitutive protein secretion from lactating mouse mammary epithelial cells by FIL (feedback inhibitor of lactation), a secreted milk protein

1993 • 71 citations

Cytological Aspects of Milk Formation and Secretion

1974 • 70 citations

Secretory vesicles externalize the major plasma membrane ATPase in yeast.

1988 • 68 citations

Microlipid droplets in milk secreting mammary epithelial cells: evidence that they originate from endoplasmic reticulum and are precursors of milk lipid globules.

1985 • 66 citations

Secretion of milk proteins.

1998 • 66 citations

Analysis of mammalian MUC1 genes reveals potential functionally important domains

1995 • 65 citations

Formation of the milk fat globule membrane without participation of the plasmalemma

1973 • 61 citations

Physical Equilibria: Lipid Phase

1988 • 58 citations

Swelling of golgi vesicles in mammary secretory cells and its relation to the yield and quantitative composition of milk

1983 • 57 citations

Biosynthesis of high molecular weight breast carcinoma associated mucin glycoproteins.

1988 • 55 citations

Function of endomembranes and the cell surface in the secretion of organic milk constituents.

1983 • 53 citations

Plasma membrane fragments in bovine and caprine skim milks

1973 • 48 citations

Freeze-fracture observations of the lactating rat mammary gland. Membrane events during milk fat secretion.

1978 • 47 citations

Lactose and major milk proteins are present in secretory vesicle-rich fractions from lactating mammary gland.

1978 • 45 citations

Ion and Water Transport in the Mammary Gland

1978 • 41 citations

Characterization of a secretory vesicle-rich fraction from lactating bovine mammary gland

1979 • 38 citations

Membranes of the Mammary Gland

1974 • 36 citations

Characterization of epithelial membrane antigen expression in human mammary epithelium by ultrastructural immunoperoxidase cytochemistry.

1986 • 35 citations

Proteins of the Milk-Fat-Globule Membrane as Markers of Mammary Epithelial Cells and Apical Plasma Membrane

1987 • 31 citations

Epithelial membrane polarity: a stable, differentiated feature of an established human breast carcinoma cell line MCF-7.

1987 • 25 citations

Monoclonal antibodies prepared against PAS-I butyrophilin and GP-55 from guinea-pig milk-fat-globule membrane bind specifically to the apical pole of secretory-epithelial cells in lactating mammary tissue

1985 • 25 citations

The role of exocytosis in the apocrine secretion of milk lipid globules in mouse mammary gland during lactogenesis

1992 • 23 citations

Identification and characterization of the principal proteins of the fat‐globule membrane from guinea‐pig milk

1985 • 22 citations

The majority of clathrin coated vesicles from lactating rabbit mammary gland arises from the secretory pathway

1999 • 19 citations

Fat droplet formation in rat lactating mammary gland and mammary carcinomas viewed by freeze-fracture.

1979 • 18 citations

Polarized expression of an apical membrane glycoprotein is established before functional tight junctions have developed in MCF-7 cells.

1989 • 16 citations

Exocytosis from permeabilized lactating mouse mammary epithelial cells. Stimulation by Ca2+ and phorbol ester, but inhibition of regulated exocytosis by guanosine 5′-[γ-thio]triphosphate

1992 • 16 citations

Internalization of ferritin-concanavalin A by the lactating mammary cell in vivo

1984 • 15 citations

Localization of a membrane glycoprotein in benign fibrocystic disease and infiltrating duct carcinomas of the human breast with the use of a monoclonal antibody to guinea pig milk fat globule membrane.

1985 • 15 citations

Internalized ricin and the plasma membrane glycoprotein MAM-6 colocalize in the trans-Golgi network of T47D human breast carcinoma cells

1989 • 15 citations

Protein synthesis in lactating guinea-pig mammary tissue perfused in vitro

1984 • 13 citations

Ultrastructural localization of a breast tumor-associated antigen.

1987 • 10 citations

Purification and characterization of a differentiation-specific sialoglycoprotein of lactating-guinea-pig mammary tissue

1988 • 10 citations

Immunogold labeling of oncogenic and tumor related proteins

1995 • 3 citations