Discovery and Development of Antineoplastic Agents from Natural Sources

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Pure appl. Chem

1983 • 3,101 citations

Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay.

1988 • 3,038 citations

Natural Products in Drug Discovery and Development

1997 • 1,631 citations

Some practical considerations and applications of the national cancer institute in vitro anticancer drug discovery screen

1995 • 1,489 citations

Medicinal plants in therapy

1987 • 1,435 citations

METHODS IN CANCER RESEARCH

1969 • 1,197 citations

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action

1998 • 984 citations

CRC Handbook of Ayurvedic Medicinal Plants

2018 • 774 citations

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

1981 • 742 citations

Isolation and structure of bryostatin 1

1982 • 638 citations

The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

1987 • 562 citations

Pharmacology and applications of chinese materia medica

1987 • 550 citations

Protein kinase C as the receptor for the phorbol ester tumor promoters: sixth Rhoads memorial award lecture.

1988 • 430 citations

Human Medicinal Agents from Plants

1993 • 373 citations

Natural Product Drug Discovery and Development: New Perspectives on International Collaboration

1995 • 361 citations

Marine natural products: metabolites of marine algae and herbivorous marine molluscs

1984 • 358 citations

Identification of okadaic acid as a toxic component of a marine dinoflagellate Prorocentrum lima.

1982 • 351 citations

Methods in Cancer Research

1979 • 318 citations

The Taxol Supply Crisis. New NCI Policies for Handling the Large-Scale Production of Novel Natural Product Anticancer and Anti-HIV Agents

1993 • 306 citations

Marine natural products: metabolites of marine invertebrates

1984 • 302 citations

Bacteriostatic and Bactericidal Substances Produced by a Soil Actinomyces.

1940 • 292 citations

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

1995 • 286 citations

Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate

1981 • 256 citations

Bryostatin, an activator of the calcium phospholipid-dependent protein kinase, blocks phorbol ester-induced differentiation of human promyelocytic leukemia cells HL-60.

1986 • 255 citations

Mycalamide A, an antiviral compound from a New Zealand sponge of the genus Mycale

1988 • 239 citations

Cancer Chemotherapeutic Agents

2000 • 237 citations

Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin

1987 • 228 citations

Biomedical Potential of Marine Natural Products

1996 • 227 citations

Rapid growth at deep-sea vents

1994 • 226 citations

Pharmacology and Applications of Chinese Materia Medica

1986 • 221 citations

Antileukemia Activity in the Oscillatoriaceae: Isolation of Debromoaplysiatoxin from Lyngbya

1977 • 221 citations

Phase I Study of Bryostatin 1: Assessment of Interleukin 6 and Tumor Necrosis Factor Induction In Vivo

1993 • 185 citations

TOXINS PRODUCED BY BENTHIC DINOFLAGELLATES

1987 • 182 citations

Ecology of deep‐sea hydrothermal vent communities: A review

1993 • 178 citations

Camptothecins New Anticancer Agents

1994 • 176 citations

Bryostatin, a non-phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor

1985 • 167 citations

Production of tetrodotoxin and its derivatives by Pseudomonas sp. isolated from the skin of a pufferfish

1987 • 154 citations

An antiinflammatory cum immunomodulatory piperidinylbenzopyranone from dysoxylum binectariferum : isolation, structure and total synthesis

1988 • 152 citations

Bryostatins: Potent, new mitogens that mimic phorbol ester tumor promoters

1985 • 140 citations

Coral reefs, forests, and thermal vents: the worldwide exploration of nature for novel antitumor agents.

1997 • 134 citations

Dispersal and Population Variation in the Bryozoan Bugula Neritina

1987 • 123 citations

Ethnobotany and Drug Discovery: The Experience of the US National Cancer Institute

2007 • 113 citations

Antineoplastic agents 100

1985 • 110 citations

Antineoplastic bryostatins are multipotential stimulators of human hematopoietic progenitor cells.

1987 • 104 citations

Antibody-Enzyme Conjugates for Cancer Therapy

1996 • 101 citations

Total synthesis of didemnins A, B, and C

1987 • 100 citations

Production of saxitoxin by cultures of Gony aulax catenella

1975 • 94 citations

Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium

1981 • 92 citations

KIN‐RECOGNITION AND THE SPATIAL DISTRIBUTION OF LARVAE OF THE BRYOZOAN BUGULA NERITINA (L.)

1984 • 90 citations

Current NCI Preclinical Antitumor Screening in Vivo: Results of Tumor Panel Screening, 1976–1982, and Future Directions

1984 • 89 citations

Didemnin B

1986 • 89 citations

Experimental screening procedures and clinical predictability value.

1966 • 85 citations

The Distribution of a Bryozoan on Seagrass Blades: Settlement, Growth, and Mortality

1986 • 82 citations

Antineoplastic agents. 3. Structure of the cyclic peptide dolastatin 3 from Dolabella auricularia

1982 • 77 citations

Toxins, anticancer agents, and tumor promoters from marine prokaryotes

1982 • 75 citations

Isolation and structure of spatol, a potent inhibitor of cell replication from the brown seaweed Spatoglossum schmittii

1980 • 72 citations

PLANT-DERIVED NATURAL PRODUCTS IN DRUG DISCOVERY AND DEVELOPMENT: AN OVERVIEW

2007 • 70 citations

Toxins from blue-green algae: structures of oscillatoxin A and three related bromine-containing toxins

1978 • 69 citations

Structure of bryostatin. 4. An important antineoplastic constituent of geographically diverse Bugula neritina (Bryozoa)

1984 • 66 citations

Structure—Activity Relationships in the Actinomycins

1973 • 60 citations

Antineoplastic agents. 119. Isolation and structure of bryostatins 10 and 11

1987 • 59 citations

The discovery of marine natural products with therapeutic potential.

1994 • 59 citations

Promising new agents under development by the Division of Cancer Treatment, Diagnosis, and Centers of the National Cancer Institute.

1997 • 57 citations

The Structure of Bryostatin 2 from the Marine Bryozoan Bugula neritina

1983 • 56 citations

Antineoplastic Agents, 118. Isolation and Structure of Bryostatin 9

1986 • 56 citations

Gnidimacrin and gnidimacrin 20-palmitate, novel macrocyclic antileukemic diterpenoid esters from Gnidia subcordata

1976 • 55 citations

Tumor inhibitors. 102. Gnididin, gniditrin, gnidicin, novel potent antileukemic diterpenoid esters from Gnidia lamprantha

1975 • 53 citations

The clinical impact of screening and other experimental tumor studies

1975 • 53 citations

Antineoplastic agents. 93. Structure of the Bugula neritina (marine bryozoa) antineoplastic component bryostatin 3

1983 • 48 citations

Antineoplastic agents. 126. Isolation and structure of bryostatins 12 and 13

1987 • 46 citations

Isolation and structure of bryostatins 5–7

1985 • 43 citations

The occurrence of saxitoxin and other toxins in various dinoflagellates

1978 • 40 citations

The Discovery of Drugs from Higher Plants

1994 • 40 citations

Kin-Recognition and the Spatial Distribution of Larvae of the Bryozoan Bugula neritina (L.)

1984 • 39 citations

Experimental studies on the settlement and growth of bryozoa in the natural environment

1981 • 25 citations

ChemInform Abstract: Role of Plants in the National Cancer Institute Drug Discovery and Development Program

1994 • 25 citations

The National Cooperative Natural Products Drug Discovery Group (NCNPDDG) and International Cooperative Biodiversity Group (ICBG) Programs

1995 • 20 citations

Large-scale recovery and purification ofl-asparaginase fromErwinia carotovora

1986 • 17 citations

Potential use of marine microorganisms for antibiotics and enzyme production

1982 • 17 citations

Relationship of Bugula neritina (Bryozoa) antineoplastic constituents to the yellow sponge Lissodendoryx isodictyalis

1986 • 15 citations

Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium californicum

1986 • 14 citations

Ecological studies of a fouling bryozoan, Bugula neritina - II. Suitable food plankton for growth of a bryozoan Bugula neritina under laboratory conditions.

1984 • 13 citations

Aerobic Actinomycetes: A Continuing Source of Novel Natural Products

1994 • 13 citations

Ecological studies of a fouling bryozoan, Bugula neritina - I. Growth of the bryozoan Bugula neritina in the sea at various water temperatures.

1984 • 12 citations

Ecological studies of a fouling bryozoan Bugula neritina. IV. The effect of low salinity on the early growth of a bryozoan Bugula neritina in the sea and laboratory.

1985 • 4 citations

Derivatization and purification of acivicin (AT-125, U-42,126).

1981 • 4 citations

Fourth World Conference on Lung Cancer

1985 • 3 citations