Mechanisms of virus pathogenicity

Defective Viral Particles and Viral Disease Processes

1970 • 683 citations

Effect of Virus Infections on the Function of the Immune System

1970 • 333 citations

Studies on the mechanism of poliovirus-induced cell damage

1965 • 288 citations

ASPECTS OF THE PATHOGENESIS OF VIRUS DISEASES

1964 • 287 citations

Macrophages and Age-Dependent Resistance to Herpes Simplex Virus in Mice

1970 • 282 citations

Pathogenesis of Viral Infections of the Nervous System

1968 • 222 citations

Selective Effects of Anti-Macrophage Serum, Silica and Anti-Lymphocyte Serum on Pathogenesis of Herpes Virus Infection of Young Adult Mice

1970 • 211 citations

A hypothesis for pulmonary clearance and its implications.

1968 • 211 citations

Double-Stranded Poliovirus RNA Inhibits Initiation of Protein Synthesis by Reticulocyte Lysates

1971 • 204 citations

HERPES-SIMPLEX-VIRUS INFECTION AFTER RENAL TRANSPLANTATION

1969 • 197 citations

Mucous flow and ciliary activity in the trachea of healthy rats and rats exposed to respiratory irritant gases (SO2, H3N, HCHO): a functional and morphologic (light microscopic and electron microscopic) study, with special reference to technique.

1956 • 195 citations

Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission

1966 • 185 citations

The Virulence of Original and Derived Strains of Semliki Forest Virus for Mice, Guinea-pigs and Rabbits

1971 • 177 citations

RESTRICTION OF HERPES SIMPLEX VIRUS BY MACROPHAGES

1971 • 174 citations

A proposed terminology for the adenovirus antigens and virion morphological subunits

1966 • 172 citations

ON THE ROLE OF THE RESPONSE OF THE CELL MEMBRANE IN DETERMINING VIRUS VIRULENCE

1966 • 169 citations

PATHOGENESIS OF CHRONIC DISEASE ASSOCIATED WITH PERSISTENT LYMPHOCYTIC CHORIOMENINGITIS VIRAL INFECTION

1970 • 163 citations

Polykaryocytosis induced by newcastle disease virus in monolayers of animal cells

1965 • 158 citations

IMMUNE COMPLEX DISEASE IN CHRONIC VIRAL INFECTIONS

1971 • 135 citations

Structure and Function of Mucosal Antibodies

1970 • 128 citations

THE EFFECT OF MENGOVIRUS INFECTION ON THE ACTIVITY OF THE DNA-DEPENDENT RNA POLYMERASE OF L-CELLS

1962 • 112 citations

Pathogenesis of immune complex glomerulonephritis of New Zealand mice.

1971 • 109 citations

A toxinlike material separable from type 5 adenovirus particles

1958 • 108 citations

Mechanism by Which Fiber Antigen Inhibits Multiplication of Type 5 Adenovirus

1967 • 102 citations

Protein Synthesis Directed by Encephalomyocarditis Virus RNA: Properties of a Transfer RNA-Dependent System

1971 • 100 citations

Incomplete Growth Cycle of Influenza Virus in Mouse Brain

1950 • 93 citations

Measurement of mucociliary function in man.

1969 • 92 citations

The mechanism of genetic resistance of chick embryo cells to infection by Rous sarcoma virus-Bryan strain (BS-RSV)

1967 • 89 citations

The Role of Arginine in the Replication of Herpes Simplex Virus

1967 • 85 citations

VIRULENCE IN NEWCASTLE DISEASE VIRUS: A Preliminary Study

1967 • 83 citations

Interaction of Influenza Virus with Leukocytes and Its Effect on Phagocytosis

1969 • 81 citations

Biochemical challenge of microbial pathogenicity

1968 • 80 citations

Organ cultures in virology.

1969 • 80 citations

STUDIES ON THE NASAL HISTOLOGY OF EPIDEMIC INFLUENZA VIRUS INFECTION IN THE FERRET

1938 • 79 citations

Microbial Pathogenicity in Man and Animals

1972 • 77 citations

Inhibition of RNA and interferon synthesis in Krebs-2 cells infected with vesicular stomatitis virus

1966 • 72 citations

Inhibition of host cell macromolecular synthesis by high multiplicities of poliovirus under conditions preventing virus synthesis

1964 • 70 citations

Mucociliary clearance rates at various levels in dog lungs.

1970 • 69 citations

The distribution of cell fusion capacity among several cell strains or cells caused by HVJ

1963 • 69 citations

Inhalation, persistence and dispersal of foot-and-mouth disease virus by man

1970 • 68 citations

Interferon Induction and Action

1971 • 68 citations

CELL-MEDIATED IMMUNE RESPONSES TO VIRUS INFECTION AND VIRUS-INDUCED TUMOURS

1967 • 66 citations

Cytopathology of mengovirus infection I. Relationship between cellular disintegration and virulence

1967 • 66 citations

Studies on the Cytopathogenicity of Newcastle Disease Virus: Relation Between Virulence, Polykaryocytosis and Plaque Size

1971 • 64 citations

Sendai Virus Replication: An Ultrastructural Comparison of Productive and Abortive Infections in Avian Cells

1970 • 62 citations

Tissue injury in lymphocytic choriomeningitis viral infection: Virus-induced immunologically specific release of a cytotoxic factor from immune lymphoid cells

1970 • 61 citations

Studies on the mechanism of poliovirus-induced cell damage

1965 • 61 citations

Relationships between viruses and leucocytes.

1966 • 61 citations

The Genetics of Animal Viruses

1964 • 60 citations

Infection patterns in mice of an avirulent and virulent strain of Semliki Forest virus.

1971 • 57 citations

IMMUNOLOGIC RESPONSE TO CYTOMEGALOVIRUS INFECTION IN RENAL ALLOGRAFT RECIPIENTS1

1969 • 57 citations

Inhibition of interferon by an infection with parainfluenza virus type 3 (PIV-3)

1963 • 57 citations

Age-Dependent Resistance of Mice to Sindbis Virus Infection: Viral Replication as a Function of Host Age

1971 • 56 citations

A new virus cultivated only in organ cultures of human ciliated epithelium

1966 • 55 citations

Attachment of Two Myxoviruses to Ciliated Epithelial Cells

1970 • 54 citations

THE USE OF BACTERIA GROWN IN VIVO FOR STUDIES ON THE BASIS OF THEIR PATHOGENICITY

1958 • 54 citations

The true division and death rates of Salmonella typhimurium in the mouse spleen determined with superinfecting phage P22.

1968 • 52 citations

Acute Viral Infection: Tissue Injury Mediated by Anti-Viral Antibody through a Complement Effector System

1971 • 52 citations

Measles virus giant cell inducing factor (fusion factor)

1965 • 51 citations

The Biological Significance of the Interferon System

1970 • 51 citations

Effect of Double-Stranded Viral RNA on Mammalian Cells in Culture

1971 • 50 citations

Pathogenesis of rashes in virus diseases

1966 • 50 citations

Age-related Cellular Resistance of the Chicken Embryo to Viral Infections. I. Interferon and Natural Resistance to Myxoviruses and Vesicular Stomatitis Virus

1970 • 47 citations

Specific role of each human leukocyte type in viral infections. 3. 17D yellow fever virus replication and interferon production in homogeneous leukocyte cultures treated with phytohemagglutinin.

1969 • 47 citations

IN VITRO INTERACTION OF MOUSE HEPATITIS VIRUS AND MACROPHAGES FROM GENETICALLY RESISTANT MICE

1970 • 46 citations

Cellular DNA and protein synthesis in reovirus-infected L cells

1969 • 45 citations

Pathogenesis of lesions in lymphoid tissue of mice infected with lymphocytic choriomeningitis (LCM) virus.

1969 • 41 citations

Patterns of Cytopathology and Lysosomal Enzyme Release in Poliovirus-infected HEp-2 Cells Treated With Either 2-( -Hydroxybenzyl)-Benzimidazole or Guanidine HCl

1970 • 41 citations

In Vitro and In Vivo Properties of Antimacrophage Sera

1969 • 40 citations

Relation of the Peripheral Multiplication of Japanese B Encephalitis Virus to the Pathogenesis of the Infection in Mice.

1963 • 40 citations

Immunosuppressive effects of macrophage antiserum.

1968 • 40 citations

Quantitative studies on the tissue localization of influenza virus in ferrets after intranasal and intravenous or intracardial inoculation.

1969 • 39 citations

Aerosol-induced adenoviral illness resembling the naturally occurring illness in military recruits.

1966 • 39 citations

Destruction of Virus-Infected Cells by Immunological Mechanisms

1971 • 37 citations

Interferon Response to Sendai and Rubella Viruses in Human Foetal Cultures, Leucocytes and Placental Cultures

1971 • 36 citations

Uncoating of Poliovirus by Isolated Plasma Membranes

1970 • 36 citations

An inhibitor of the production of interferon (“blocker”)

1966 • 35 citations

Tissue-specific Factor required for the Translation of a Mammalian Viral RNA

1970 • 35 citations

Studies on the Cytopathic Effects of Newcastle Disease Virus: Metabolic Requirements

1971 • 35 citations

Stimulating interaction between viruses (stimulons).

1967 • 34 citations

Factors in the Pathogenesis of Virus Diseases

1962 • 34 citations

Biochemical Studies on the Cytopathic Effect of Influenza Viruses

1967 • 33 citations

Role of Interferon in Replication of Virulent and Attenuated Strains of Measles Virus

1969 • 32 citations

Two Variants of Sindbis Virus Which Differ in Interferon Induction and Serum Clearance. I. The Phenomenon

1969 • 30 citations

Growth patterns of influenza virus in cultures of ferret organs.

1970 • 28 citations

The susceptibility of monkey kidney cells to poliovirus in vivo and in vitro

1955 • 25 citations

PATHOGENESIS OF INFLUENZA

1961 • 25 citations

Persistent respiratory virus infection in tracheal organ cultures.

1969 • 25 citations

Isolation of Two Plaque Mutants of Western Equine Encephalitis Virus Differing in Virulence for Mice

1969 • 23 citations

Enhancement of Virus Multiplication and Interferon Production by Cortisone in Ocular Herpesvirus Infection

1970 • 23 citations

EXPERIMENTALLY INDUCED CHANGES IN NASAL MUCOUS SECRETORY SYSTEMS AND THEIR EFFECT ON VIRUS INFECTION IN CHICKENS

1969 • 22 citations

Lack of Effect of Immunosuppression on Scrapie Infection in Mice

1971 • 22 citations

Mengovirus-Induced Cytopathic Effect in L-Cells: Protective Effect of Interferon

1969 • 21 citations

The response of mice to the intravenous injection of cowpox virus.

1968 • 21 citations

DNS-, RNS- und Proteinsynthese und ihre Relation zur Riesenzellbildung in vitro nach Infektion mit Herpesvirus hominis

1968 • 21 citations

Malaria in Mammals Excluding Man

1967 • 21 citations

Phagocytosis of influenza virus. II. Its occurrence in normal and immune mice.

1957 • 21 citations

On the mechanism of the cytopathic changes produced in human amnion cell cultures by the molluscum contagiosum virus

1966 • 20 citations

Growth in chick chorioallantoic membranes of strains of Newcastle disease virus of differing virulence

1970 • 19 citations

Feline Herpesvirus Infection in Fused Cultures of Naturally Resistant Human Cells

1969 • 19 citations

Destruction of L Cells by Mengo Virus: Use of Interferon to Study the Mechanism

1968 • 18 citations

The nature of toxins of herpes simplex virus

1968 • 18 citations

Pathogenesis of and recovery from respiratory syncytial and influenza infections in ferrets

1969 • 17 citations

Counteraction between interferon and enhancer

1966 • 17 citations

The Chick Embryo for the Study of Infection and Immunity

1970 • 17 citations

Growth of infectious bovine rhinotracheitis virus in organ cultures.

1968 • 16 citations

Biological and biochemical basis for cell injury by animal viruses.

1961 • 16 citations

Studies of the basis of localization of influenza virus in ferret organ cultures.

1972 • 15 citations

Immunocytologic study of nasal epithelial cells in influenza.

1969 • 14 citations

Protein Leakage from Mengovirus-Infected Cells.

1967 • 13 citations

EXPERIMENTALLY INDUCED CHANGES IN NASAL MUCOUS SECRETORY SYSTEMS AND THEIR EFFECT ON VIRUS INFECTION IN CHICKENS

1969 • 13 citations

Influence of Type and Concentration of Sera in vitro on Susceptibility of Genetically Resistant Cells to Mouse Hepatitis Virus

1971 • 13 citations

ON THE ABILITY OF CERTAIN VIRUSES TO BLOCK THE EFFECT OF INTERFERON.

1965 • 12 citations

Influence of blood clearance rates on interferon production and virulence of Mengo virus plaque mutants in mice

1970 • 11 citations

Virulence and In-Vitro Characteristics of Four Mutants of Newcastle Disease Virus

1971 • 11 citations

The significance of kinin-destroying enzymes activity in Plasmodium knowlesi malarial infection.

1970 • 11 citations

Nonspecific Factors in Monkey Tissues and Serum Causing Inhibition of Plaque Formation and Hemagglutination by Dengue Viruses

1971 • 10 citations

Poxvirus phagocytosis in vivo: electron microscopy of macrophages, mast cells, and leukocytes.

1971 • 9 citations

THE SEARCH FOR PROTECTIVE ANTIGENS

1969 • 9 citations

Recent progress in research on interferons.

1967 • 9 citations

Mycoplasmas as Infectious Agents

1970 • 9 citations

A substance enhancing virus growth and antagonistic to interferon action

1968 • 8 citations

An Antiviral Substance in the Tissues of Mice Acutely Infected with Lymphocytic Choriomeningitis Virus

1971 • 7 citations

Infection of pigeons by airborne Venezuelan equine encephalitis virus

1966 • 7 citations

Interaction of plasma membranes with influenza virus. II. Release of viral nucleoprotein.

1971 • 7 citations

Interaction of plasma membranes with influenza virus. 3. Electron microscopic study of interactions between influenza virus and isolated plasma membranes.

1971 • 6 citations

Enhancing effect of human erythrocyte extracts on the susceptibility of monkey kidney cells to certain enteroviruses.

1966 • 5 citations

Studies on the susceptibility of mouse muscle cultures to Coxsackie A-4 viruses in vitro.

1965 • 4 citations

Interaction of Leucine with Vaccinia Virus Infection in Mice and Cell Cultures

1969 • 4 citations

Influence of anti-leucocyte serum on intraperitoneal vaccinia virus infection of rats.

1970 • 3 citations

Role of Serum Protective Factor and Neutralizing Antibody in Pathogenesis of Experimental Infection with Langat Virus in Mice

1970 • 3 citations

Morphological Changes And Resistance To Vaccinia Virus Induced In Human Amnion Cells By Yeast Extract

1971 • 3 citations

Vaccinia virus peritoneal infection in rats of different ages.

1969 • 3 citations

TOXIC ACTIVITIES OF MICROBES

1969 • 2 citations

Saturated fatty acids in poliovirus host cell interaction. I. Stimulation and inhibition of virion uptake.

1968 • 2 citations

The importance of particle size in airborne viral respiratory infections

1970 • 2 citations