Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations

THE ISOTOPIC COMPOSITION OF REDUCED ORGANIC CARBON

1980 • 1,311 citations

Protein turnover in mammalian tissues and in the whole body

1978 • 1,237 citations

Measurement of de novo hepatic lipogenesis in humans using stable isotopes.

1991 • 364 citations

Regulation of Hepatic De Novo Lipogenesis in Humans

1996 • 341 citations

The design and analysis of isotope experiments

1960 • 325 citations

Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers

1992 • 275 citations

Contributions of de novo synthesis of fatty acids to total VLDL-triglyceride secretion during prolonged hyperglycemia/hyperinsulinemia in normal man.

1996 • 217 citations

The measuring procedure and corrections for the high-precision mass-spectrometric analysis of isotopic abundance ratios, especially referring to carbon, oxygen and nitrogen

1973 • 172 citations

Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis

1974 • 161 citations

The inhibition of gluconeogenesis following alcohol in humans

1998 • 130 citations

Gluconeogenesis and Intrahepatic Triose Phosphate Flux in Response to Fasting or Substrate Loads. APPLICATION OF THE MASS ISOTOPOMER DISTRIBUTION ANALYSIS TECHNIQUE WITH TESTING OF ASSUMPTIONS AND POTENTIAL PROBLEMS

1995 • 126 citations

Determinants and regulation of cytoplasmic mRNA stability in eukaryotic cells

1991 • 119 citations

Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase

1992 • 113 citations

Quantification of menstrual and diurnal periodicities in rates of cholesterol and fat synthesis in humans.

1993 • 90 citations

Mass isotopomer pattern and precursor-product relationship

1992 • 88 citations

Model equations for condensation biosynthesis using stable isotopes and radioisotopes

1992 • 87 citations

Limitations of the Mass Isotopomer Distribution Analysis of Glucose to Study Gluconeogenesis

1995 • 84 citations

Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis.

1991 • 84 citations

Measuring Protein Synthesis by Mass Isotopomer Distribution Analysis (MIDA)

1999 • 71 citations

Measurement of endogenous synthesis of plasma cholesterol in rats and humans using MIDA

1993 • 71 citations

Correction for the metabolic exchange of 14C for 12C atoms in the pathway of gluconeogenesis in vivo.

1982 • 62 citations

Measuring gluconeogenesis with [2-13C]glycerol and mass isotopomer distribution analysis of glucose

1995 • 50 citations

Concentration dependence of methyl palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry

1993 • 49 citations

Glucose Homeostasis in Children with Falciparum Malaria: Precursor Supply Limits Gluconeogenesis and Glucose Production1

1997 • 48 citations

Nonhomogeneous labeling of liver mitochondrial acetyl-CoA

1991 • 48 citations

Relationship between precursor enrichment and ratio of excess M2/excess M1 isotopomer frequencies in a secreted polymer

1991 • 48 citations

Isotopomer spectral analysis of cholesterol synthesis: applications in human hepatoma cells

1994 • 41 citations

Sampling the lipogenic hepatic acetyl-CoA pool in vivo in the rat. Comparison of xenobiotic probe to values predicted from isotopomeric distribution in circulating lipids and measurement of lipogenesis and acetyl-CoA dilution

1991 • 41 citations

Comparison of mass isotopomer dilution methods used to compute VLDL production in vivo

1996 • 37 citations

Molecular ion fragmentation and its effects on mass isotopomer abundances of fatty acid methyl esters ionized by electron impact

1999 • 27 citations

Conformational analysis through selective isotopic substitution: supersonic jet spectroscopic determination of the minimum energy conformation of o-xylene

1992 • 18 citations

Calculations for Gluconeogenesis by Mass Isotopomer Distribution Analysis

1995 • 13 citations

Prohormone Convertase 1 in Obesity, Gestational Diabetes Mellitus, and NIDDM: No Evidence for a Major Susceptibility Role

1998 • 12 citations

Testing gas chromatographic/mass spectrometric systems for linearity of response

1995 • 11 citations

Gas-phase acid-base chemistry and its effects on mass isotopomer abundance measurements of biomolecular ions

1998 • 9 citations