Physiological Perspectives on Leptin as a Regulator of Reproduction: Role in Timing Puberty1

Positional cloning of the mouse obese gene and its human homologue

1994 • 12,975 citations

The Physiology of Reproduction

1988 • 7,765 citations

Growth at Adolescence

1978 • 3,839 citations

Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

1995 • 3,730 citations

Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks

1995 • 3,302 citations

Role of leptin in the neuroendocrine response to fasting

1996 • 3,106 citations

A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

1998 • 2,333 citations

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

1996 • 1,505 citations

Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice

1978 • 1,274 citations

Leptin is a metabolic signal to the reproductive system.

1996 • 1,037 citations

Early Onset of Reproductive Function in Normal Female Mice Treated with Leptin

1997 • 844 citations

REGULATION OF ENERGY INTAKE AND THE BODY WEIGHT: THE GLUCOSTATIC THEORY AND THE LIPOSTATIC HYPOTHESIS

1955 • 838 citations

Leptin accelerates the onset of puberty in normal female mice.

1997 • 768 citations

Role of leptin in hypothalamic–pituitary function

1997 • 744 citations

Metabolic fuels and reproduction in female mammals

1992 • 677 citations

Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function.

1998 • 625 citations

Leptin's Actions on the Reproductive Axis: Perspectives and Mechanisms

1999 • 542 citations

Leptin Is a Metabolic Gate for the Onset of Puberty in the Female Rat

1997 • 506 citations

Leptin Inhibition of the Hypothalamic-Pituitary-Adrenal Axis in Response to Stress¹

1997 • 460 citations

Body weight and food intake as initiating factors for puberty in the rat

1963 • 441 citations

A Longitudinal Assessment of Hormonal and Physical Alterations during Normal Puberty in Boys. V. Rising Leptin Levels May Signal the Onset of Puberty¹

1997 • 435 citations

Control of fertility by metabolic cues

1996 • 419 citations

Body fat, menarche, fitness and fertility

1987 • 362 citations

Evidence for GnRH Regulation by Leptin: Leptin Administration Prevents Reduced Pulsatile LH Secretion during Fasting

1998 • 314 citations

Expression and Localization of the Leptin Receptor in Endocrine and Neuroendocrine Tissues of the Rat

1997 • 313 citations

Insulin-like growth factor I of peripheral origin acts centrally to accelerate the initiation of female puberty.

1996 • 286 citations

Effects of Leptin on Insulin Sensitivity in Normal Rats*

1997 • 271 citations

FACTORS AFFECTING THE SECRETION OF LUTEINIZING HORMONE IN THE EWE

1984 • 236 citations

Insulin-Like Growth Factor I: A Possible Metabolic Signal Involved in the Regulation of Female Puberty

1991 • 215 citations

Nutrition and reproduction

1996 • 193 citations

Pubertal adipose tissue: is it necessary for normal sexual maturation? Evidence from the rat and human female.

1980 • 168 citations

Availability of Metabolic Fuels Controls Estrous Cyclicity of Syrian Hamsters

1989 • 163 citations

Influence of Endogenous Leptin Tone on the Estrous Cycle and Luteinizing Hormone Pulsatility in Female Rats

1997 • 158 citations

Chronic Administration of Leptin into the Lateral Ventricle Induces Sexual Maturation in Severely Food‐restricted Female Rats

1998 • 139 citations

Circulating Leptin Does Not Appear to Provide a Signal for Triggering the Initiation of Puberty in the Male Rhesus Monkey (Macaca Mulatta)

1997 • 135 citations

Hormonal Regulation of the Peripubertal Surge of Insulin-Like Growth Factor-I in the Rat*

1987 • 135 citations

Reduction of glucose availability suppresses pulsatile luteinizing hormone release in female and male rats.

1996 • 134 citations

Evidence for a Leptin-Neuropeptide Y Axis for the Regulation of Growth Hormone Secretion in the Rat

1998 • 131 citations

Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability.

1996 • 118 citations

Suppression of luteinizing hormone pulses by restriction of glucose availability is mediated by sensors in the brain stem.

1996 • 117 citations

The Neuroendocrine Aspects of Reproduction

1983 • 107 citations

Serum leptin concentrations in relation to pubertal development

1997 • 106 citations

Leptin Indirectly Affects Estrous Cycles by Increasing Metabolic Fuel Oxidation

1998 • 105 citations

Plasma leptin in children: Relationship to puberty, gender, body composition, insulin sensitivity, and energy expenditure

1998 • 100 citations

Involvement of the catecholaminergic input to the paraventricular nucleus and of corticotropin-releasing hormone in the fasting-induced suppression of luteinizing hormone release in female rats.

1994 • 100 citations

The role of intracerebral insulin in the effect of nutrition on gonadotrophin secretion in mature male sheep

1995 • 95 citations

Human Fatty Marrow Aromatizes Androgen to Estrogen

1980 • 89 citations

Leptin and ciliary neurotropic factor (CNTF) inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y

1998 • 79 citations

Pubertal Endocrinology of the Baboon: Elevated Somatomedin-C/Insulin-Like Growth Factor I at Puberty

1982 • 78 citations

A Biphasic Developmental Pattern of Circulating Leptin in the Male Rhesus Macaque (Macaca mulatta)*

1998 • 77 citations

Ontogeny of Pulsatile Luteinizing Hormone and Testosterone Secretion in Male Lambs*

1978 • 73 citations

Comparison of the Effects of 2-Deoxyglucose and Immobilization on Plasma Levels of Catecholamines and Corticosterone in Awake Rats

1979 • 71 citations

Reversal of fasting-induced suppression of luteinizing hormone (LH) secretion in male rhesus monkeys by intragastric nutrient infusion: evidence for rapid stimulation of LH by nutritional signals.

1993 • 67 citations

METABOLIC SIGNALS FOR THE ONSET OF PUBERTY

1983 • 58 citations

Caudal brain stem plays a role in metabolic control of estrous cycles in Syrian hamsters

1994 • 55 citations

Developmental patterns of plasma insulin-like growth factor-1 concentrations in sheep

1990 • 55 citations

Hypothalamic GLUT 4 expression: a glucose- and insulin-sensing mechanism?

1995 • 54 citations

Suppression of luteinizing hormone secretion during short-term fasting in male rhesus monkeys: the role of metabolic versus stress signals.

1993 • 52 citations

Adipose tissue and reproduction

1990 • 43 citations

The neurobiology of puberty

1995 • 36 citations

Lack of a role of the hypothalamic-pituitary-adrenal axis in the fasting-induced suppression of luteinizing hormone secretion in adult male rhesus monkeys (Macaca mulatta).

1993 • 32 citations

Novel estrogen feedback sites associated with stress-induced suppression of luteinizing normone secretion in female rats

1996 • 25 citations

Search for the signal that conveys metabolic status to the reproductive axis

1997 • 8 citations