Lifestyle Factors, Exposures, Genetic Susceptibility, and Renal Cell Cancer Risk: A Review

1969 Cancer Facts and Figures

1968 • 8,880 citations

Cancer statistics, 1999

1999 • 3,154 citations

Overweight and obesity in the United States: prevalence and trends, 1960–1994

1997 • 3,098 citations

Identification of the von Hippel-Lindau Disease Tumor Suppressor Gene

1993 • 2,906 citations

Rising Incidence of Renal Cell Cancer in the United States

1999 • 1,593 citations

Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

2002 • 1,541 citations

Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas

1997 • 1,508 citations

Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.

1997 • 1,003 citations

Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dubé syndrome

2002 • 882 citations

Body Mass Index and the Prevalence of Hypertension and Dyslipidemia

2000 • 843 citations

Obesity, Hypertension, and the Risk of Kidney Cancer in Men

2000 • 661 citations

DOSE-RESPONSE RELATION BETWEEN ARSENIC CONCENTRATION IN WELL WATER AND MORTALITY FROM CANCERS AND VASCULAR DISEASES

1989 • 640 citations

Malignant neoplasms among residents of a blackfoot disease-endemic area in Taiwan: high-arsenic artesian well water and cancers.

1985 • 618 citations

MORTALITY EXPERIENCE OF INSULATION WORKERS IN THE UNITED STATES AND CANADA, 1943‐1976*

1979 • 589 citations

Renal Tumors in the Birt-Hogg-Dubé Syndrome

2002 • 578 citations

Lung and kidney cancer mortality associated with arsenic in drinking water in Cordoba, Argentina

1998 • 476 citations

Ecological correlation between arsenic level in well water and age-adjusted mortality from malignant neoplasms.

1990 • 434 citations

Incidence of Transitional Cell Carcinoma and Arsenic in Drinking Water: A Follow-up Study of 8,102 Residents in an Arseniasis-endemic Area in Northeastern Taiwan

2001 • 397 citations

Somatic mutations of the von Hippel — Lindau disease tumour suppressor gene in non-familial clear cell renal carcinoma

1994 • 371 citations

Regulation of microtubule stability by the von Hippel-Lindau tumour suppressor protein pVHL

2002 • 330 citations

Global increases in kidney cancer incidence, 1973–1992

2002 • 307 citations

Lead and cancer in humans: Where are we now?

2000 • 284 citations

Occupational risk factors for renal cell carcinoma: agent-specific results from a case-control study in Germany

2000 • 284 citations

The Zucker rat model of obesity, insulin resistance, hyperlipidemia, and renal injury.

1992 • 263 citations

Lead as a carcinogen: Experimental evidence and mechanisms of action

2000 • 263 citations

Arsenic concentrations in well water and risk of bladder and kidney cancer in Finland.

1999 • 260 citations

Identification of the von Hippel-Lindau (VHL) gene. Its role in renal cancer

1995 • 259 citations

Inactivation of the von Hippel–Lindau ( VHL ) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL ‐independent pathway in clear cell renal tumourigenesis

1998 • 255 citations

A Population-Based Case-Control Study of Renal Cell Carcinoma

1984 • 250 citations

Biomarkers in the identification of risks, especially with regard to susceptible persons and subgroups

1999 • 248 citations

Hereditary Renal Cancers

2003 • 243 citations

Acquired Cystic Kidney Disease

1990 • 242 citations

CANCER MORTALITY AMONG CADMIUM PRODUCTION WORKERS

1976 • 236 citations

Cigarette Smoking, Obesity, Diuretic Use, and Coffee Consumption as Risk Factors for Renal Cell Carcinoma<xref ref-type="fn" rid="FN1">2</xref>

1986 • 229 citations

Cancer Incidence among Finnish Workers Exposed to Halogenated Hydrocarbons

1995 • 227 citations

VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation.

2000 • 227 citations

Association of cadmium with renal cancer

1976 • 221 citations

Risk factors for renal cell carcinoma: results of a population-based case-control study

1993 • 220 citations

Comprehensive Textbook of Genitourinary Oncology

1997 • 214 citations

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for aVHL-independent pathway in clear cell renal tumourigenesis

1998 • 212 citations

Organic solvents and cancer.

1997 • 208 citations

The von Hippel–Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis

2002 • 202 citations

Identification of the von Hippel-Lindau (VHL) Gene

1995 • 198 citations

International renal‐cell cancer study. IV. Occupation

1995 • 195 citations

Increased incidence of renal cell tumors in a cohort of cardboard workers exposed to trichloroethene

1995 • 185 citations

Magnetic Field Exposure and Neurodegenerative Disease Mortality among Electric Utility Workers

1998 • 182 citations

International renal cell cancer study. VII. role of diet

1996 • 175 citations

A CASE-CONTROL STUDY OF FACTORS AFFECTING THE DEVELOPMENT OF RENAL CELL CANCER

1986 • 171 citations

Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up.

1998 • 169 citations

Mortality Among a Cohort of U.S. Cadmium Production Workers—an Update

1985 • 168 citations

Hippel-Lindau disease: MR imaging.

1988 • 166 citations

Retrospective cohort mortality study of workers at an aircraft maintenance facility. I. Epidemiological results.

1991 • 166 citations

International renal‐cell cancer study. I. Tobacco use

1995 • 163 citations

Cancer mortality of cadmium workers.

1985 • 160 citations

A Case-Control Study of Diet and Risk of Renal Adenocarcinoma

1990 • 160 citations

Renal cell cancer and occupational exposure to chemical agents.

1991 • 159 citations

Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States).

2002 • 158 citations

Increased frequency of a null-allele for NAD(P)H: quinone oxidoreductase in patients with urological malignancies

1997 • 155 citations

Renal cell carcinoma and occupational exposure to chemicals in Canada

2002 • 154 citations

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched- related gene, TRC8

1998 • 154 citations

Cancers related to exposure to arsenic at a copper smelter.

1995 • 153 citations

Causes of death among laundry and dry cleaning workers.

1979 • 150 citations

Hypertension, obesity and their medications in relation to renal cell carcinoma

1998 • 147 citations

Risk factors for renal‐cell cancer in Shanghai, China

1992 • 146 citations

Associations between Cigarette Smoking and Each of 21 Types of Cancer: A Multi-Site Case-Control Study

1995 • 145 citations

International renal‐cell cancer study. VIII. Role of diuretics, other anti‐hypertensive medications and hypertension

1995 • 141 citations

Racial Misclassification of Native Americans in a Surveillance, Epidemiology, and End Results Cancer Registry

1992 • 140 citations

Asbestos and cancer: a cohort followed up to death.

1987 • 139 citations

Epidemiology of Adenocarcinoma of the Kidney<xref ref-type="fn" rid="fn2">²</xref>

1974 • 139 citations

Associations of Cancer Mortality With Halomethanes in Drinking Water

1978 • 138 citations

Trichloroethylene Exposure and Specific Somatic Mutations in Patients With Renal Cell Carcinoma

1999 • 137 citations

Duplication and overexpression of the mutant allele of the MET proto-oncogene in multiple hereditary papillary renal cell tumours

1998 • 136 citations

FAMILIAL RENAL ONCOCYTOMA: CLINICOPATHOLOGICAL STUDY OF 5 FAMILIES

1998 • 134 citations

Population Attributable Risk of Renal Cell Cancer in Minnesota

1998 • 133 citations

MORTALITY OF LEAD SMELTER WORKERS

1985 • 131 citations

Cancer in asbestos-exposed occupational cohorts: a meta-analysis.

1999 • 129 citations

Risk factors for kidney cancer in New South Wales, Australia. II. Urologic disease, hypertension, obesity, and hormonal factors

1992 • 129 citations

The Metabolic Syndrome and Insulin-Like Growth Factor I Regulation in Adolescent Obesity1

1998 • 129 citations

Cancer and other causes of death among a cohort of dry cleaners.

1990 • 124 citations

Occupationally Related Cancer Risk Among Coke Oven Workers: 30 Years of Follow-Up

1995 • 124 citations

Mortality among employees of lead battery plants and lead-producing plants, 1947-1980.

1985 • 124 citations

A case-control study of risk factor for renal cell cancer in northern Italy

1990 • 123 citations

Candidate genetic modifiers of individual susceptibility to renal cell carcinoma: a study of polymorphic human xenobiotic-metabolizing enzymes.

1999 • 121 citations

Female laundry and dry cleaning workers in Wisconsin: a mortality analysis.

1981 • 120 citations

Exposure assessment of trichloroethylene.

2000 • 120 citations

A historical prospective study of European stainless steel, mild steel, and shipyard welders.

1991 • 120 citations

Renal cell cancer correlated with occupational exposure to trichloroethene

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Updated and expanded Swedish cohort study on trichloroethylene and cancer risk.

1994 • 119 citations

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Occupational exposure to diesel engine emissions and risk of cancer in Swedish men and women.

2001 • 117 citations

International renal‐cell cancer study. III. Role of weight, height, physical activity, and use of amphetamines

1995 • 116 citations

Renal Toxicity and Carcinogenicity of Trichloroethylene: Key Results, Mechanisms, and Controversies

2000 • 116 citations

A Critical Review of Cancer Epidemiology in the Petroleum Industry, with a Meta-analysis of a Combined Database of More Than 350,000 Workers

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Hepatocyte growth factor induces proliferation and morphogenesis in nonparenchymal epithelial liver cells

1993 • 113 citations

Chronic renal failure: A significant risk factor in the development of acquired renal cysts and renal cell carcinoma. Case reports and review of the literature

1986 • 113 citations

Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case‐control study in Arnsberg, Germany

2003 • 113 citations

Long-term mortality study of steelworkers. VI. Mortality from malignant neoplasms among coke oven workers.

1972 • 112 citations

Risk factors in renal cell carcinoma: I. Methodology, demographics, tobacco, beverage use, and obesity.

1988 • 112 citations

Hypertension, Antihypertensive Medication Use, and Risk of Renal Cell Carcinoma

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Cruciferous vegetables in relation to renal cell carcinoma

1998 • 108 citations

Mortality and cancer morbidity among cadmium-exposed workers

1979 • 108 citations

Mortality Among Workers Employed in Petroleum Refining and Petrochemical Plants

1980 • 106 citations

Natural history of acquired renal cystic disease in dialysis patients: a prospective longitudinal CT study.

1991 • 105 citations

Cancer incidence in urban bus drivers and tramway employees: a retrospective cohort study

1998 • 103 citations

Diet and risk of renal cell cancer: a population-based case-control study.

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Associations between several sites of cancer and twelve petroleum-derived liquids. Results from a case-referent study in Montreal.

1987 • 101 citations

Studying interactions of four proteins in the yeast two-hybrid system: Structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein

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The role of obesity and weight fluctuations in the etiology of renal cell cancer: a population-based case-control study.

1994 • 100 citations

SOURCE OF DRINKING WATER AT HOME AND SITE-SPECIFIC CANCER INCIDENCE IN WASHINGTON COUNTY, MARYLAND

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MORTALITY AMONG SHIPYARD WORKERS IN GENOA, ITALY

1979 • 98 citations

A retrospective study of renal cancer with special reference to coffee and animal protein consumption

1976 • 98 citations

The mortality of lead smelter workers: an update.

1992 • 97 citations

International renal-cell-cancer study. VI. The role of medical and family history

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Mortality patterns among workers in three Texas oil refineries.

1982 • 94 citations

Risk factors for cancer of the renal parenchyma

1988 • 94 citations

Influence of polymorphisms of GSTM1 and GSTT1 for risk of renal cell cancer in workers with long-term high occupational exposure to trichloroethene

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ASBESTOS IN DRINKING WATER AND CANCER INCIDENCE IN THE SAN FRANCISCO BAY AREA

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Occupational Mortality Among Firefighters

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Cancer Incidence Among Danish Workers Exposed to Trichloroethylene

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Cigarette Smoking and Risk of Bladder, Pancreas, Kidney, and Colorectal Cancers in Iowa

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International renal‐cell cancer study. II. Analgesics

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Mortality among laundry and dry cleaning workers in Oklahoma.

1984 • 87 citations

Tobacco use in relation to renal cell carcinoma.

1998 • 87 citations

Mortality studies of aluminum reduction plant workers: potroom and carbon department.

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Risk factors for renal‐cell carcinoma in a French case‐control study

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International renal‐cell cancer study. V. Reproductive factors, gynecologic operations and exogenous hormones

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Chlorination of Drinking Water and Cancer Mortality in Taiwan

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Risk factors for renal‐cell carcinoma in Denmark. III. Role of weight, physical activity and reproductive factors

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Occupational risk factors for renal-cell carcinoma in Denmark.

1994 • 80 citations

Asbestos and renal adenocarcinoma: A case-control study

1987 • 80 citations

Tea Consumption and Risk of Bladder and Kidney Cancers In a Population-based Case-Control Study

2000 • 80 citations

CANCER MORTALITY PATTERNS ASSOCIATED WITH EXPOSURE TO METALS*

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Retrospective cohort mortality study of dry cleaner workers using perchloroethylene.

1987 • 78 citations

Cancer mortality in female and male dry-cleaning workers.

1994 • 75 citations

Risk Factors for Renal Cell Carcinoma in Denmark: Role of Medication and Medical History

1994 • 74 citations

Patterns of cancer mortality among Native Americans

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Extended Mortality Follow-up of a Cohort of Dry Cleaners

2003 • 73 citations

Risk factors in renal cell carcinoma. II. Medical history, occupation, multivariate analysis, and conclusions.

1988 • 73 citations

Cancer mortality among printing plant workers

1979 • 72 citations

Peripheral differential leukocyte counts in humans vary with hyperlipidemia, smoking, and body mass index

2001 • 71 citations

Drinking Water Mutagenicity and Urinary Tract Cancers: A Population-based Case-Control Study in Finland

1998 • 71 citations

Mortality of aircraft manufacturing workers in Southern California

1988 • 70 citations

A retrospective mortality study among Canadian petroleum marketing and distribution workers.

1993 • 70 citations

Mortality of Aerospace Workers Exposed to Trichloroethylene

1998 • 69 citations

Gender differences in risk of renal cell carcinoma and occupational exposures to chlorinated aliphatic hydrocarbons

1999 • 69 citations

Incidence of and mortality from cancer in hypertensive patients.

1993 • 69 citations

Dietary risk factors for renal cell carcinoma in Denmark

1996 • 68 citations

A critical review of epidemiology studies of trichloroethylene and perchloroethylene and risk of renal-cell cancer

1997 • 68 citations

Mortality Among US Commercial Pilots And Navigators

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Glutathione S-transferase M1, T1, and P1 polymorphisms as risk factors for renal cell carcinoma: a case-control study.

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Cancer mortality among coke oven workers.

1983 • 67 citations

A Case-Control Study of Renal Cell Carcinoma in Relation to Occupation, Smoking, and Alcohol Consumption

1988 • 67 citations

Health effects of gasoline exposure. II. Mortality patterns of distribution workers in the United States.

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Family history and risk of renal cell carcinoma.

2001 • 66 citations

Unusual mortality experience of printing pressmen.

1977 • 64 citations

Gender, Alcohol Consumption, and Renal Cell Carcinoma

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Risk factors for kidney cancer in New South Wales—I. Cigarette smoking

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1993 • 64 citations

Cancer at sea: a case-control study among male Finnish seafarers

2002 • 63 citations

HIGH BLOOD PRESSURE AND 17-YEAR CANCER MORTALITY IN THE WESTERN ELECTRIC HEALTH STUDY1

1981 • 62 citations

Mortality and cancer morbidity in workers from an aluminium smelter with prebaked carbon anodes--Part II: Cancer morbidity.

1995 • 61 citations

Occurrence of Urinary Tract Tumors in Miners Highly Exposed to Dinitrotoluene

1999 • 58 citations

Annual cancer incidence rates for hispanics in the United States

2000 • 57 citations

Mortality study of cancer risk among oil refinery workers

1989 • 57 citations

VHL gene alterations in renal cell carcinoma patients: novel hotspot or founder mutations and linkage disequilibrium

2001 • 57 citations

Risk of renal cell cancer in relation to diuretics, antihypertensive drugs, and hypertension.

1995 • 57 citations

Increased risk of renal cell carcinoma subsequent to hysterectomy.

1999 • 56 citations

Gene-Environment Interactions in Renal Cell Carcinoma

2001 • 55 citations

Occupational risk lor renal cell carcinoma. A case‐control study based on the New Zealand Cancer Registry

1995 • 55 citations

Kidney cancer and occupational exposure to asbestos: a meta-analysis of occupational cohort studies.

2000 • 55 citations

Renal cell carcinomas in trichloroethene(TRI) exposed persons are associated with somatic mutations in the von Hippel-Lindau ( VHL ) tumour suppressor gene

1997 • 55 citations

Von Hippel‐Lindau disease

2003 • 55 citations

A 39-year follow-up of the U.K. oil refinery and distribution center studies: results for kidney cancer and leukemia.

1993 • 54 citations

Cause-Specific Mortality Among Newspaper Web Pressmen

1980 • 53 citations

Occupational risk factors for renal cell carcinoma in Montreal

2000 • 53 citations

Cohort Mortality Study of Pulp and Paper Mill Workers in British Columbia, Canada

1997 • 53 citations

Occupation, Smoking and Demographic Factors, and Renal Cell Carcinoma in Germany

1995 • 51 citations

Cancer Incidence Among Finnish Oil Refinery Workers, 1971-1994

1998 • 49 citations

Improving cancer incidence estimates for American Indians in Minnesota.

1999 • 48 citations

Reproductive factors and the risk of renal cell cancer among women

1995 • 48 citations

Petroleum-related employment and renal cell cancer.

1985 • 47 citations

Chemical-induced nephrotoxicity mediated by glutathione S-conjugate formation

2001 • 47 citations

Mortality of Italian lead smelter workers

1997 • 46 citations

Cancer risk among health care personnel in Finland, 1971-1980.

1990 • 45 citations

Patterns of mortality among plumbers and pipefitters

1986 • 44 citations

Physical activity and risk of renal cell cancer

2001 • 43 citations

Asbestos and kidney cancer: The evidence supports a causal association

1989 • 43 citations

Kidney cancer and hydrocarbon exposures among petroleum refinery workers.

1993 • 42 citations

Occupational exposure to chlorinated aliphatic hydrocarbons: Job exposure matrix

1994 • 40 citations

Epidemiologic evidence of cancer in aluminum reduction plant workers

1992 • 40 citations

Case-control study of hydrocarbon exposures in patients with renal cell carcinoma.

1989 • 38 citations

Occupational Risk Factors for Renal Cell Cancer: A Case-Control Study in Northern Italy

2002 • 37 citations

Induction of nuclear catechol-O-methyltransferase by estrogens in hamster kidney: implications for estrogen-induced renal cancer

1998 • 37 citations

Cancer risk among oil refinery workers. A review of epidemiologic studies.

1984 • 37 citations

Occupational risk factors for renal cell cancer. An Italian case-control study.

2002 • 36 citations

Asbestos fibers in human pulmonary and extrapulmonary tissues

1988 • 35 citations

The genetic basis of renal epithelial tumors: advances in research and its impact on prognosis and therapy

2001 • 35 citations

Occupational risks for renal cancer in Sweden.

1987 • 35 citations

Use of analgesics and risk of renal cell cancer

1994 • 33 citations

Cancer incidence in hypertensives

1987 • 33 citations

Extended mortality follow‐up among men and women in a U.S. furniture workers union

1994 • 31 citations

Sex Hormone‐dependent Renal Cell Carcinogenesis Induced by Ferric Nitrilotriacetate in Wistar Rats

1995 • 31 citations

Role of lead-binding proteins in renal cancer.

1994 • 30 citations

Proportionate mortality among unionized construction ironworkers

1997 • 30 citations

A case‐control study of renal cancer mortality at a texas chemical plant

1985 • 29 citations

Kidney cancer in utility workers exposed to polychlorinated biphenyls (PCBs)

1989 • 29 citations

Cancer in Asbestos-Mining and Other Areas of Quebec 2

1977 • 29 citations

Elevated Systolic Blood Pressure as a Predictor of Long-Term Cancer Mortality: Analysis by Site and Histologic Subtype in 10,000 Middle-Aged and Elderly Men&lt;xref ref-type="fn" rid="FN1"&gt;2&lt;/xref&gt;

1986 • 29 citations

Association of GSTT1 non-null and NAT1 slow/rapid genotypes with von Hippel-Lindau tumour suppressor gene transversions in sporadic renal cell carcinoma

2001 • 28 citations

Molecular epidemiology of VHL gene mutations in renal cell carcinoma patients: relation to dietary and other factors

2002 • 27 citations

Morphology and anatomic localization of renal microneoplasms and proximal tubule dysplasias induced by four different estrogens in the hamster.

1990 • 25 citations

Renal cell cancer and exposure to gasoline: a review.

1993 • 24 citations

Renal Cell Cancer among Paperboard Printing Workers

1992 • 23 citations

Cancer incidence following exposure to drinking water with asbestos leachate.

1989 • 23 citations

Occupational risk factors for renal cell carcinoma: a case-control study.

1994 • 21 citations

Mortality Among Three Refinery/Petrochemical Plant Cohorts. II. Retirees

2000 • 20 citations

Extra-Hepatic Gsh–Dependent Metabolism Of 1,2-Dibromoethane (Dbe) And 1,2-Dibromo-3-Chloropropane (Dbcp) IN The Rat And Mouse

1984 • 20 citations

Mortality and Cancer Morbidity among Cadmium-Exposed Workers

1979 • 19 citations

The use of asbestos-cement pipe for public water supply and the incidence of cancer in selected communities in Utah

1984 • 18 citations

Carcinogenicity of Gasoline: A Review of Epidemiological Evidence

1997 • 17 citations

Padrão de mortalidade por câncer em trabalhadores eletricitários

2002 • 16 citations

Mortality Among Three Refinery/Petrochemical Plant Cohorts

2002 • 15 citations

Asbestos fibers in normal and cancerous human kidneys

1981 • 15 citations

GEOGRAPHIC PATTERNS OF CANCER RISK: A MEANS FOR IDENTIFYING POSSIBLE OCCUPATIONAL FACTORS

1976 • 14 citations

Expression of HIF-1 and ubiquitin in conventional renal cell carcinoma

2003 • 13 citations

Renal cell carcinoma among architects

1991 • 13 citations

Insulin-like growth factor 1 receptors are increased in estrogen-induced kidney tumors.

1993 • 13 citations

Reproductive functions in obese women.

1993 • 12 citations

Long-Term Mortality Study of Steelworkers

1974 • 11 citations

Long-term mortality study of stellworkers. VII. Mortality patterns among crane operators.

1974 • 11 citations

Kidney and Bladder Cancer in Inuit 1969-1988

1996 • 9 citations

Renal cell cancer among architects and allied professionals in Sweden

1992 • 6 citations