Early thrombolytic treatment in acute myocardial infarction: reappraisal of the golden hour

Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17,187 cases of suspected acute myocardial infarction: ISIS-2. ISIS-2 (Second International Study of Infarct Survival) Collaborative Group.

1988 • 2,740 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

Indications for fibrinolytic therapy in suspected acute myocardial infarction : collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients

1994 • 2,250 citations

Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients

1994 • 2,186 citations

The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs duration of coronary occlusion in dogs.

1977 • 1,927 citations

TRIAL OF TISSUE PLASMINOGEN ACTIVATOR FOR MORTALITY REDUCTION IN ACUTE MYOCARDIAL INFARCTION

1988 • 1,161 citations

Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction. Results of the TIMI IIIB Trial. Thrombolysis in Myocardial Ischemia.

1994 • 1,003 citations

ISIS-3 - A RANDOMIZED COMPARISON OF STREPTOKINASE VS TISSUE PLASMINOGEN-ACTIVATOR VS ANISTREPLASE AND OF ASPIRIN PLUS HEPARIN VS ASPIRIN ALONE AMONG 41,299 CASES OF SUSPECTED ACUTE MYOCARDIAL-INFARCTION

1992 • 898 citations

ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction

1992 • 866 citations

Western Washington Randomized Trial of Intracoronary Streptokinase in Acute Myocardial Infarction

1983 • 805 citations

A Prospective Trial of Intravenous Streptokinase in Acute Myocardial Infarction (I.S.A.M.)

1986 • 705 citations

Prehospital-Initiated vs Hospital-Initiated Thrombolytic Therapy

1993 • 673 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

Effects of tissue plasminogen activator and a comparison of early invasive and conservative strategies in unstable angina and non-Q-wave myocardial infarction: Results of the TIMI IIIB trial

1994 • 498 citations

IMPROVED SURVIVAL AFTER EARLY THROMBOLYSIS IN ACUTE MYOCARDIAL INFARCTION

1985 • 450 citations

Prehospital Thrombolytic Therapy in Patients with Suspected Acute Myocardial Infarction

1993 • 402 citations

Intravenous tissue plasminogen activator and size of infarct, left ventricular function, and survival in acute myocardial infarction.

1988 • 386 citations

Late Assessment of Thrombolytic Efficacy (LATE) study with alteplase 6-24 hours after onset of acute myocardial infarction

1993 • 361 citations

Cardiac rupture, mortality and the timing of thrombolytic therapy: A meta-analysis

1990 • 282 citations

The Western Washington Intravenous Streptokinase in Acute Myocardial Infarction Randomized Trial.

1988 • 246 citations

DOUBLE-BLIND RANDOMISED TRIAL OF INTRAVENOUS TISSUE-TYPE PLASMINOGEN ACTIVATOR VERSUS PLACEBO IN ACUTE MYOCARDIAL INFARCTION

1985 • 242 citations

Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.

1988 • 232 citations

Feasibility, safety, and efficacy of domiciliary thrombolysis by general practitioners: Grampian region early anistreplase trial. GREAT Group.

1992 • 230 citations

The association between cardiac events and myocardial ischaemia following thrombolysis in acute myocardial infarction and the impact of carvedilol

1996 • 189 citations

Acute myocardial infarction: pre-hospital and in-hospital management: The Task Force on the Management of Acute Myocardial Infarction of the European Society of Cardiology

1996 • 188 citations

Randomised trial of late thrombolysis in patients with suspected acute myocardial infarction

1993 • 165 citations

Serial angiographic assessment of coronary artery obstruction and collateral flow in acute myocardial infarction. Report from the second Mount Sinai-New York University Reperfusion Trial.

1989 • 159 citations

Reperfusion in acute myocardial infarction: Effect of timing and modulating factors in experimental models

1993 • 147 citations

Time to thrombolytic treatment: Factors affecting delay and their influence on outcome

1995 • 140 citations

Which patients benefit most from early thrombolytic therapy with intracoronary streptokinase?

1986 • 135 citations

Temporal trends and factors associated with extent of delay to hospital arrival in patients with acute myocardial infarction: The Worcester Heart Attack Study

1994 • 127 citations

LATE assessment of thrombolytic efficacy with alteplase (rt‐PA) six‐24 hours after onset of acute myocardial infarction

1993 • 126 citations

Prehospital thrombolysis in acute myocardial infarction

1990 • 126 citations

Prehospital use of APSAC: Results of a placebo-controlled study

1989 • 126 citations

Implications for acute intervention related to time of hospital arrival in acute myocardial infarction

1986 • 124 citations

Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction

1989 • 118 citations

Prevention of Myocardial Infarction by Very Early Treatment with Intracoronary Streptokinase

1984 • 112 citations

Myocardial reperfusion in the pig heart model: infarct size and duration of coronary occlusion

1987 • 101 citations

Influence of collateral blood flow and of variations in MV̇O2 on tissue-ATP content in ischemic and infarcted myocardium

1987 • 92 citations

Thrombolysis in patients with unstable angina improves the angiographic but not the clinical outcome. Results of UNASEM, a multicenter, randomized, placebo-controlled, clinical trial with anistreplase.

1992 • 90 citations

Tailored thrombolytic therapy. A perspective.

1993 • 84 citations

Very early thrombolytic therapy in suspected acute myocardial infarction

1990 • 79 citations

Improved survival but not left ventricular function with early and prehospital treatment with tissue plasminogen activator in acute myocardial infarction

1990 • 70 citations

Prehospital thrombolysis with alteplase (rt-PA) in acute myocardial infarction

1992 • 67 citations

Comparison of intravenous urokinase plus heparin versus heparin alone in acute myocardial infarction

1991 • 59 citations

Treatment of acute myocardial infarction with anisoylated plasminogen streptokinase activator complex.

1986 • 46 citations

Determinants of infarct size in non-human primates

1990 • 44 citations

A double blind placebo controlled study of early and late administration of recombinant tissue plasminogen activator in acute myocardial infarction.

1989 • 40 citations

Prehospital thrombolysis in a rural community: Short- and long-term survival

1992 • 31 citations

Very early thrombolytic therapy in suspected acute myocardial infarctionThe Thrombolysis in Acute Heart Attack Trial Study Group Am J Cardiol 65:401–407 Feb 1990

1990 • 19 citations

Thrombolytic Therapy Within One Hour of the Onset of Acute Myocardial Infarction

1991 • 11 citations

Thrombolysis in refractory unstable angina

1991 • 10 citations

Peaking time of creatine-kinase MB in patients treated with urokinase or conventionally during acute myocardial infarction: is it really a clue to reperfusion?

1988 • 2 citations

Fibrinolytic therapy in suspected acute myocardial infarction

1994 • 1 citations