Role of calcium antagonists in cardiovascular therapy.

Calcium and muscle contraction

1968 • 1,745 citations

Specific Pharmacology of Calcium in Myocardium, Cardiac Pacemakers, and Vascular Smooth Muscle

1977 • 1,745 citations

A further Contribution regarding the influence of the different Constituents of the Blood on the Contraction of the Heart

1883 • 941 citations

Differentiation of the transmembrane Na and Ca channels in mammalian cardiac fibres by the use of specific inhibitors

1972 • 602 citations

CALCIUM‐INDUCED RELEASE OF CALCIUM FROM THE SARCOPLASMIC RETICULUM OF SKINNED CELLS FROM ADULT HUMAN, DOG, CAT, RABBIT, RAT, AND FROG HEARTS AND FROM FETAL AND NEW‐BORN RAT VENTRICLES*

1978 • 469 citations

Nifedipine Therapy for Coronary-Artery Spasm

1980 • 421 citations

Membrane calcium current in ventricular myocardial fibres

1970 • 401 citations

Coronary Artery Spasm as a Cause of Acute Myocardial Ischemia in Man

1975 • 389 citations

Immediate Effects of Intravenous Verapamil in Cardiac Arrhythmias

1972 • 311 citations

Coronary arterial spasm and Prinzmetal's variant form of angina induced by hyperventilation and Tris-buffer infusion.

1978 • 304 citations

Effect of Verapamil on the Sinoatrial and Atrioventricular Nodes of the Rabbit and the Mechanism by Which it Arrests Reentrant Atrioventricular Nodal Tachycardia

1974 • 285 citations

Effects of Agents which Inhibit the Slow Channel on Sinus Node Automaticity and Atrioventricular Conduction in the Dog

1974 • 284 citations

Membrane Currents in Cardiac Muscle Fibers

1973 • 268 citations

Variant Form of Angina Pectoris

1960 • 246 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. II. Effects on exercise capacity and symptomatic status.

1979 • 237 citations

Effect of Verapamil on the Normal Action Potential and on a Calcium Dependent Slow Response of Canine Cardiac Purkinje Fibers

1974 • 229 citations

Verapamil therapy: a new approach to the pharmacologic treatment of hypertrophic cardiomyopathy. I. Hemodynamic effects.

1979 • 226 citations

Treatment of hypertrophic obstructive cardiomyopathy with verapamil.

1979 • 207 citations

Effects of intravenous verapamil on cardiac arrhythmias and on the electrocardiogram

1975 • 203 citations

Management of unstable angina at rest by verapamil. A double-blind cross-over study in coronary care unit.

1979 • 201 citations

Verapamil in the treatment of paroxysmal supraventricular tachycardia

1974 • 195 citations

Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.

1980 • 193 citations

Effects of intravenous verapamil on hemodynamics in patients with heart disease

1977 • 192 citations

FINE STRUCTURAL CHANGES IN MYOCARDIAL ISCHEMIC INJURY.

1965 • 191 citations

Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris

1973 • 188 citations

Effects of verapamil on myocardial performance in coronary disease.

1979 • 182 citations

Effect of Diltiazem on Electrical and Mechanical Activity of Isolated Cardiac Ventricular Muscle of Guinea Pig

1975 • 181 citations

A protective effect of verapamil on hypoxic heart muscle

1976 • 175 citations

Prevention of ventricular fibrillation induced by coronary ligation.

1968 • 173 citations

Nifedipine therapy for stable angina pectoris: Preliminary results of effects on angina frequency and treadmill exercise response

1979 • 173 citations

Effect of procainamide, propranolol and verapamil on mechanism of tachycardia in patients with chronic recurrent ventricular tachycardia

1977 • 170 citations

Effect of diltiazem, a calcium antagonist, on myocardial ischemia

1979 • 157 citations

Effect of verapamil studied by programmed electrical stimulation of the heart in patients with paroxysmal re-entrant supraventricular tachycardia.

1977 • 154 citations

Effects of verapamil on infarct size following experimental coronary occlusion

1975 • 133 citations

The treatment of hypertension with verapamil.

1978 • 130 citations

Effect of nifedipine on atrioventricular conduction as compared with verapamil. Intracardiac electrophysiological study.

1979 • 126 citations

VERAPAMIL IN CHRONIC STABLE ANGINA

1980 • 124 citations

III. CALCIUM ANTAGONISTS

1980 • 123 citations

Regional contractility. Selective depression of ischemic myocardium by verapamil.

1976 • 123 citations

The effects of nifedipine on acute experimental myocardial ischemia and infarction in dogs.

1979 • 122 citations

Production of ischaemic cardiac pain by nifedipine.

1978 • 122 citations

Action of verapamil on sinus node, atrioventricular, and intraventricular conduction.

1973 • 117 citations

Disturbed myocardial calcium metabolism: a possible pathogenetic factor in the hereditary cardiomyopathy of the Syrian hamster.

1975 • 117 citations

Nifedipine in the treatment of prinzmetal's (variant) angina

1979 • 117 citations

Effects of nifedipine after intravenous and intracoronary administration

1979 • 115 citations

Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel".

1979 • 105 citations

Protective effect of verapamil on vulnerability to ventricular fibrillation during myocardial ischaemia and reperfusion

1980 • 105 citations

Antianginal efficiency of nifedipine with and without a beta‐blocker, studied with exercise test. A double‐blind, randomized subacute study

1979 • 104 citations

Nifedipine therapy for refractory coronary arterial spasm

1979 • 104 citations

[BAY a 1040--a highly potent Ca ++ -antagonistic inhibitor of electro-mechanical coupling processes in mammalian myocardium].

1972 • 100 citations

Provocative testing with ergonovine to evaluate the efficacy of treatment with calcium antagonists in variant angina.

1979 • 99 citations

The Beneficial Effects of Verapamil in Chronic Atrial Fibrillation

1979 • 98 citations

Die Bedeutung der energiereichen Phosphate für Kontraktilität und Tonus des Myokards

1964 • 96 citations

Biochemistry and histology of the connective tissue of Dupuytren's disease lesions

1980 • 96 citations

Effect of nifedipine on myocardial ischemia: Analysis of collateral flow, pulsatile heat and regional muscle shortening

1979 • 96 citations

Calciumantagonistische Therapie bei hypertroph-obstruktiver Kardiomyopathie

1976 • 94 citations

Hypotensive Action and Increased Plasma Renin Activity by Ca<sup>2+</sup> Antagonist (Nifedipine) in Hypertensive Patients

1976 • 92 citations

ARRHYTHMIA AS A CAUSE OF SUDDEN DEATH IN HYPERTROPHIC CARDIOMYOPATHY

1976 • 86 citations

Pharmacological protection of mitochondrial function in hypoxic heart muscle: Effect of verapamil, propranolol, and methylprednisolone

1978 • 84 citations

Effect of nitroglycerin, intensain, isoptin and papaverine on coronary blood flow in man

1966 • 84 citations

The effect of -adrenoceptor and Ca2+ antagonist drugs on the hypoxia-induced increase in resting tension

1978 • 69 citations

The slow membrane channel as the predominant mediator of the excitation process of the sinoatrial pacemaker cell

1976 • 64 citations

Haemodynamic effects of intravenous verapamil at rest and during exercise in subjectively healthy middle-aged men

1975 • 61 citations

The muscarinic receptor of heart cell membranes Association with agonists, antagonists and antiarrhythmic agents

1977 • 60 citations

DOUBLE BLIND EVALUATION OF ORALLY ADMINISTERED IPROVERATRIL IN PATIENTS WITH ANGINA PECTORIS

1966 • 59 citations

Comparison of myocardial protection with nifedipine and potassium.

1979 • 54 citations

Objective assessment of treatment in severe angina.

1979 • 54 citations

Basic Actions of Ions and Drugs on Myocardial High-Energy Phosphate Metabolism and Contractility

1975 • 46 citations

Effects of verapamil on sinus node function in man.

1978 • 43 citations

Myosin phosphorylation, cell motility and smooth muscle contraction

1978 • 42 citations

The effect of verapamil on the calcium paradox.

1980 • 40 citations

Effect of Nifedipine (Adalat®) on Coronary Haemodynamics in Patients with Coronary Arteriosclerotic Disease

1978 • 40 citations

Evidence of a new, preferentially Mg-carrying, transport system besides the fast Na and the slow Ca channels in the excited myocardial sarcolemma membrane*1

1979 • 39 citations

The relationship between posture, blood pressure and electrophysiological properties in patients with paroxysmal supraventricular tachycardia.

1978 • 33 citations

Verapamil in the Management of Hypertensive Patients

1979 • 33 citations

Calcium-Antagonismus, ein Grundprinzip der Vasodilatation

1980 • 32 citations

Comparison of verapamil and practolol in paroxysmal supraventricular tachycardia.

1976 • 32 citations

Beneficial Effect of Diltiazem, a New Antianginal Drug, on Angina Pectoris at Rest

1979 • 31 citations

The systemic and coronary hemodynamic effects of iproveratril.

1971 • 26 citations

[THE IMPORTANCE OF ENERGY-RICH PHOSPHATE FOR CONTRACTILITY AND TONUS OF THE MYOCARDIUM].

1964 • 24 citations

Suppression of Repeatedly Occurring Ventricular Fibrillation with Nifedipine in Variant Form of Angina Pectoris

1977 • 20 citations

Effects of niludipine (Bay a 7168) on the cardiovascular system with a note on its calcium-antagonistic effects.

1979 • 19 citations

Effects of verapamil in ventricular premature beats of acute myocardial infarction.

1978 • 18 citations

Alterations in Calcium Transport and Binding by the Plasma Membrane of Mesenteric Arteries from Spontaneously Hypertensive Rats

1977 • 17 citations

Fundamental physiology of coronary smooth musculature from extramural stem arteries of pigs and rabbits. (Electric excitability, tension development, influence of Ca, Mg, H and K ions).

1978 • 17 citations

[Fundamental cardiovascular effects of the Ca++ antagonistic coronary drug fendiline (author's transl)].

1977 • 9 citations

Clinical Studies on the Combined Effect of Various Antihypertensive Agents and Adalat

1975 • 3 citations

Radiotherapy in Modern Clinical Practice

1976 • 2 citations

ARRHYTHMIA AND MORTALITY IN HYPERTROPHIC CARDIOMYOPATHY

1980 • 1 citations