Prevention of Acute Ischemic Renal Failure by Targeted Delivery of Growth Factors to the Proximal Tubule in Transgenic Mice

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters.

1992 • 4,885 citations

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

1996 • 779 citations

Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice.

1994 • 414 citations

Epidermal growth factor enhances renal tubule cell regeneration and repair and accelerates the recovery of renal function in postischemic acute renal failure.

1989 • 400 citations

Hepatocyte growth factor: Renotropic role and potential therapeutics for renal diseases

2001 • 335 citations

Osteogenic protein-1 (bone morphogenetic protein-7) reduces severity of injury after ischemic acute renal failure in rat.

1998 • 328 citations

Dysregulation of Met receptor tyrosine kinase activity in invasive tumors

2002 • 269 citations

Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells

1991 • 259 citations

Hepatocyte Growth Factor Overexpression in the Islet of Transgenic Mice Increases Beta Cell Proliferation, Enhances Islet Mass, and Induces Mild Hypoglycemia

2000 • 244 citations

Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter

2000 • 219 citations

Overexpression of parathyroid hormone-related protein in the skin of transgenic mice interferes with hair follicle development.

1994 • 210 citations

Hepatocyte growth factor accelerates recovery from acute ischemic renal injury in rats

1994 • 208 citations

Insulin-like growth factor I accelerates recovery from ischemic acute tubular necrosis in the rat.

1992 • 203 citations

Parathyroid Hormone-Related Protein

1995 • 199 citations

Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury

2000 • 173 citations

Attenuation of renal ischemia-reperfusion injury in inducible nitric oxide synthase knockout mice

1999 • 162 citations

Guanosine supplementation reduces apoptosis and protects renal function in the setting of ischemic injury

2001 • 149 citations

Overexpression of Parathyroid Hormone-related Protein in the Pancreatic Islets of Transgenic Mice Causes Islet Hyperplasia, Hyperinsulinemia, and Hypoglycemia

1996 • 143 citations

Therapeutic use of growth factors in renal failure.

1994 • 141 citations

Single Injection of Naked Plasmid Encoding Hepatocyte Growth Factor Prevents Cell Death and Ameliorates Acute Renal Failure in Mice

2002 • 124 citations

Up-regulation of hepatocyte growth factor receptor: An amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure

1999 • 121 citations

Parathyroid hormone related peptide can function as an autocrine growth factor in human renal cell carcinoma

1990 • 113 citations

Keratinocyte expression of transgenic hepatocyte growth factor affects melanocyte development, leading to dermal melanocytosis

2000 • 95 citations

Hepatocyte Growth Factor Protects Renal Epithelial Cells from Apoptotic Cell Death

1998 • 89 citations

Expression of parathyroid hormone-related protein in the rat glomerulus and tubule during recovery from renal ischemia.

1993 • 82 citations

Targeting of the rasT24 oncogene to the proximal convoluted tubules in transgenic mice results in hyperplasia and polycystic kidneys.

1993 • 81 citations

Renal tubular hyperplasia, polycystic disease, and glomerulosclerosis in transgenic mice overexpressing hepatocyte growth factor/scatter factor.

1997 • 79 citations

Cell Type-specific Secretion of Parathyroid Hormone-related Protein via the Regulated versus the Constitutive Secretory Pathway

1995 • 71 citations

Parathyroid hormone-related protein detection and interaction with NO and cyclic AMP in the renovascular system

1996 • 68 citations

The five amino acid-deleted isoform of hepatocyte growth factor promotes carcinogenesis in transgenic mice

1999 • 65 citations

Angiotensin II Increases Parathyroid Hormone-Related Protein (PTHrP) and the Type 1 PTH/PTHrP Receptor in the Kidney

2002 • 59 citations

Expressions of receptor gene for hepatocyte growth factor in kidney after unilateral nephrectomy and renal injury

1992 • 56 citations

Renal expression of parathyroid hormone-related protein (PTHrP) and PTH/PTHrP receptor in a rat model of tubulointerstitial damage

1999 • 52 citations

Hepatocyte Growth Factor Receptor in Acute Tubular Necrosis

2001 • 50 citations

Parathyroid hormone-related protein is an autocrine modulator of rabbit proximal tubule cell growth

1995 • 37 citations

Parathyroid Hormone-Related Protein as a Renal Regulating Factor

2001 • 33 citations

Up-regulation of parathyroid hormone-related protein in folic acid-induced acute renal failure

2001 • 31 citations

Hepatocyte growth factor inhibits apoptosis after ischemic renal injury in rats

2001 • 29 citations

Treatment of acute tubular necrosis.

1990 • 25 citations

The mouse gamma-glutamyl transpeptidase gene is transcribed from at least five separate promoters.

1994 • 24 citations

CYCLOSPORINE INCREASES RENAL PARATHYROID HORMONE-RELATED PROTEIN EXPRESSION IN VIVO IN THE RAT1

1998 • 23 citations

Fibroblast growth factor protects the kidney against ischemia-reperfusion injury.

1999 • 23 citations

Expression and Role of Parathyroid Hormone-Related Protein in Human Renal Proximal Tubule Cells during Recovery from ATP Depletion

1999 • 22 citations

Co-purification of calcium transport-stimulating and DNA synthesis-stimulating agents with parathormone-like activity isolated from the hypercalcaemic strain of the Walker 256 tumour

1991 • 16 citations

Acute failure of the transplanted kidney--pathophysiology, diagnosis and prevention.

1996 • 12 citations