Roles of molecular chaperones in protein degradation.

THE FUNCTION OF HEAT-SHOCK PROTEINS IN STRESS TOLERANCE: DEGRADATION AND REACTIVATION OF DAMAGED PROTEINS

1993 • 2,177 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

Heat shock proteins: molecular chaperones of protein biogenesis

1993 • 598 citations

Regulation by proteolysis: energy-dependent proteases and their targets

1992 • 458 citations

A molecular chaperone, ClpA, functions like DnaK and DnaJ.

1994 • 358 citations

Homology in Structural Organization BetweenE. coliClpAP Protease and the Eukaryotic 26 S Proteasome

1995 • 303 citations

p34^Cdc28-Mediated Control of Cln3 Cyclin Degradation

1995 • 293 citations

The ClpX heat-shock protein of Escherichia coli, the ATP-dependent substrate specificity component of the ClpP-ClpX protease, is a novel molecular chaperone.

1995 • 247 citations

Molecular chaperones cooperate with PIM1 protease in the degradation of misfolded proteins in mitochondria.

1994 • 237 citations

Heat shock regulatory gene htpR influences rates of protein degradation and expression of the lon gene in Escherichia coli.

1984 • 217 citations

Escherichia coli heat shock gene mutants are defective in proteolysis.

1988 • 205 citations

Involvement of the chaperonin dnaK in the rapid degradation of a mutant protein in Escherichia coli.

1992 • 199 citations

A gene regulating the heat shock response in Escherichia coli also affects proteolysis.

1984 • 171 citations

Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes

1994 • 134 citations

Rapid degradation of an abnormal protein in Escherichia coli involves the chaperones GroEL and GroES.

1994 • 128 citations

The ubiquitin-activating enzyme, E1, is required for stress-induced lysosomal degradation of cellular proteins

1991 • 101 citations

Mechanisms of membrane protein turnover

1990 • 73 citations

Divergent effects of a dnaK mutation on abnormal protein degradation in Escherichia coli

1988 • 55 citations

2 Cytosolic hsp70s of Saccharomyces cerevisiae : Roles in Protein Synthesis, Protein Translocation, Proteolysis, and Regulation

1994 • 54 citations

Hsp70 in mitochondrial biogenesis: From chaperoning nascent polypeptide chains to facilitation of protein degradation

1994 • 48 citations

6 Heat Shock 70-kD Proteins and Lysosomal Proteolysis

1994 • 16 citations