Gastric Bypass for Obesity: Mechanisms of Weight Loss and Diabetes Resolution

Ghrelin is a growth-hormone-releasing acylated peptide from stomach

1999 • 8,261 citations

The Disease Burden Associated With Overweight and Obesity

1999 • 5,006 citations

Obesity as a medical problem

2000 • 4,948 citations

Ghrelin induces adiposity in rodents

2000 • 3,915 citations

A role for ghrelin in the central regulation of feeding

2001 • 3,415 citations

A Preprandial Rise in Plasma Ghrelin Levels Suggests a Role in Meal Initiation in Humans

2001 • 2,865 citations

Who Would Have Thought It? An Operation Proves to Be the Most Effective Therapy for Adult-Onset Diabetes Mellitus

1995 • 2,296 citations

Gut hormone PYY3-36 physiologically inhibits food intake

2002 • 2,263 citations

Gastrointestinal Surgery for Severe Obesity

1991 • 2,142 citations

Inhibition of Food Intake in Obese Subjects by Peptide YY_3–36

2003 • 1,549 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 1,521 citations

Hypophysial Responses to Continuous and Intermittent Delivery of Hypothalamic Gonadotropin-Releasing Hormone

1978 • 1,363 citations

Outcomes After Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity

2000 • 1,341 citations

Effect of 6-week course of glucagon-like peptide 1 on glycaemic control, insulin sensitivity, and β-cell function in type 2 diabetes: a parallel-group study

2002 • 1,295 citations

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

2001 • 1,231 citations

Effect of Laparoscopic Roux-En Y Gastric Bypass on Type 2 Diabetes Mellitus

2003 • 1,187 citations

Laparoscopic Gastric Bypass, Roux en-Y - 500 Patients: Technique and Results, with 3-60 month follow-up

2000 • 871 citations

Vertical Banded Gastroplasty for Obesity

1982 • 709 citations

Ghrelin, a Natural GH Secretagogue Produced by the Stomach, Induces Hyperglycemia and Reduces Insulin Secretion in Humans

2001 • 684 citations

Effect of Duodenal–Jejunal Exclusion in a Non-obese Animal Model of Type 2 Diabetes

2003 • 627 citations

Screening and Interventions for Obesity in Adults: Summary of the Evidence for the U.S. Preventive Services Task Force

2003 • 618 citations

Enhancing Incretin Action for the Treatment of Type 2 Diabetes

2003 • 578 citations

A Randomized Prospective Trial of Gastric Bypass Versus Vertical Banded Gastroplasty for Morbid Obesity and their Effects on Sweets Versus Non-Sweets Eaters

1987 • 548 citations

Surgical treatment of obesity

1969 • 542 citations

The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus

1997 • 520 citations

Plasma ghrelin levels and hunger scores in humans initiating meals voluntarily without time- and food-related cues

2004 • 517 citations

Plasma Acylation-Stimulating Protein, Adiponectin, Leptin, and Ghrelin before and after Weight Loss Induced by Gastric Bypass Surgery in Morbidly Obese Subjects

2003 • 509 citations

Diabetes and Hypertension in Severe Obesity and Effects of Gastric Bypass-Induced Weight Loss

2003 • 501 citations

Bariatric Surgery and Long-term Control of Morbid Obesity

2002 • 487 citations

A Prospective Comparison of Gastric and Jejunoileal Bypass Procedures for Morbid Obesity

1977 • 471 citations

The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion

2000 • 454 citations

Medicinal strategies in the treatment of obesity

2000 • 436 citations

Genetics and Pathophysiology of Human Obesity

2003 • 381 citations

Potential of Surgery for Curing Type 2 Diabetes Mellitus

2002 • 375 citations

Stomach Is a Major Source of Circulating Ghrelin, and Feeding State Determines Plasma Ghrelin-Like Immunoreactivity Levels in Humans

2001 • 372 citations

Current status of medical and surgical therapy for obesity

2001 • 322 citations

Ghrelin and Adipose Tissue Regulatory Peptides: Effect of Gastric Bypass Surgery in Obese Humans

2003 • 320 citations

Does obesity surgery improve psychosocial functioning? A systematic review

2003 • 311 citations

Ghrelin Modulates the Downstream Molecules of Insulin Signaling in Hepatoma Cells

2002 • 292 citations

Roles for Ghrelin in the Regulation of Appetite and Body Weight

2003 • 282 citations

A New Paradigm for Type 2 Diabetes Mellitus

1998 • 280 citations

Glucagon-Like Peptide-1 and the Islet β-Cell: Augmentation of Cell Proliferation and Inhibition of Apoptosis

2003 • 268 citations

Surgery : scientific principles and practice

2001 • 260 citations

Vagotomy Dissociates Short- and Long-Term Controls of Circulating Ghrelin

2003 • 260 citations

Meal-Related Ghrelin Suppression Requires Postgastric Feedback

2003 • 232 citations

Ten and more years after vertical banded gastroplasty as primary operation for morbid obesity

2000 • 227 citations

Weight Loss in Severely Obese Subjects Prevents the Progression of Impaired Glucose Tolerance to Type II Diabetes: A longitudinal interventional study

1994 • 227 citations

Gastrointestinal Hormone Responses to Meals Before and After Gastric Bypass and Vertical Banded Gastroplasty

1990 • 210 citations

Changes in eating behavior after horizontal gastroplasty and Roux-en-Y gastric bypass

1990 • 204 citations

Ghrelin: a Gut-Brain Hormone: Effect of Gastric Bypass Surgery

2003 • 202 citations

Gastrointestinal hormones and gastric emptying 20 years after jejunoileal bypass for massive obesity

1997 • 197 citations

Changes of Body Weight and Plasma Ghrelin Levels after Gastric Banding and Gastric Bypass

2004 • 194 citations

Ghrelin and Gastric Bypass: Is There a Hormonal Contribution to Surgical Weight Loss?

2003 • 189 citations

Gastric Bypass and Vertical Banded Gastroplasty- a Prospective Randomized Comparison and 5-Year Follow-up

1995 • 184 citations

Clinical and cost effectiveness of surgery for morbid obesity: a systematic review and economic evaluation

2003 • 171 citations

Different Plasma Ghrelin Levels after Laparoscopic Gastric Bypass and Adjustable Gastric Banding in Morbid Obese Subjects

2003 • 170 citations

Effects of Obesity Surgery on Non–Insulin-Dependent Diabetes Mellitus

2002 • 170 citations

Two-Month Treatment of Obese Subjects with the Oral Growth Hormone (GH) Secretagogue MK-677 Increases GH Secretion, Fat-Free Mass, and Energy Expenditure¹

1998 • 163 citations

Gut hormone changes after jejunoileal (JIB) or biliopancreatic (BPB) bypass surgery for morbid obesity.

1981 • 160 citations

Gastric Partitioning for Morbid Obesity

1979 • 156 citations

Effect of Weight Loss on Insulin Sensitivity and Intramuscular Long-Chain Fatty Acyl-CoAs in Morbidly Obese Subjects

2002 • 153 citations

Appetitive behavior after gastric bypass for obesity.

1981 • 146 citations

Importance of Small Bowel Peptides for the Improved Glucose Metabolism 20 Years after Jejunoileal Bypass for Obesity

1998 • 142 citations

Serum Ghrelin Levels in Response to Glucose Load in Obese Subjects Post‐Gastric Bypass Surgery

2003 • 132 citations

Laparoscopic gastric bypass Another option in bariatric surgery

1996 • 126 citations

Distal small bowel hormones: correlation with fasting antroduodenal motility and gastric emptying.

1998 • 113 citations

Prospective Evaluation of Vertical Banded Gastroplasty as the Primary Operation for Morbid Obesity

1991 • 113 citations

Long- or short-limb gastric bypass?

2001 • 99 citations

Experience with the Roux-en-Y Gastric Bypass, and Commentary on Current Trends

2000 • 99 citations

Quality of life after gastric bypass for morbid obesity.

1991 • 90 citations

Diet, behavior modification, and exercise: a review of obesity treatments from a long-term perspective.

1991 • 89 citations

Effect of weight loss on muscle lipid content in morbidly obese subjects

2003 • 88 citations

Weight Loss and Food Intake 18 Months following Vertical Banded Gastroplasty or Gastric Bypass for Severe Obesity

1995 • 87 citations

Enhanced dietary fat clearance in postobese women

2001 • 68 citations

Muscle insulin receptor concentrations in obese patients post bariatric surgery: relationship to hyperinsulinemia

2004 • 63 citations

A prospective randomized comparison of gastric bypass and gastroplasty. Complications and early results.

1986 • 63 citations

The effects of ileal transposition and jejunoileal bypass on food intake and GI hormone levels in rats

1984 • 63 citations

Gastric bypass versus gastroplasty. A prospective study of differences in two surgical procedures for morbid obesity.

1987 • 55 citations

Gastric bypass for obesity after ten years experience.

1978 • 51 citations

Plasma Ghrelin Concentratin in the Short-Term following Biliopancreatic Diversion

2003 • 50 citations

Pancreatic polypeptide, pancreatic glucagon and enteroglucagon in morbid obesity and following gastric bypass operation.

1986 • 49 citations

Gastric banding, a surgical method of treating morbid obesity: preliminary report.

1983 • 40 citations

Physiological satiety implications of gastrointestinal antiobesity surgery

1992 • 39 citations

Human gut hormone profiles in patients with short bowel syndrome

1992 • 39 citations

Effect of Continuous Somatostatin and Growth Hormone-Releasing Hormone (GHRH) Infusions on the Subsequent Growth Hormone (GH) Response to GHRH

1987 • 37 citations

Eating Behavior After Gastric Bypass Surgery for Obesity

1987 • 36 citations

Gut and Pancreatic Hormones after Jejunoileal Bypass with 3:1 or 1:3 Jejunoileal Ratio

1983 • 24 citations

Effect of ileojejunal transposition on gastrointestinal motility, gastric emptying, and small intestinal transit in dogs

1999 • 22 citations

The cost-effectiveness of bariatric surgery. Craig BM, Tseng DS. Cost-Effectiveness of Gastric Bypass for Severe Obesity, Am J Intern Med 2002;113:491-8

2003 • 18 citations

Ileojejunal Transposition Delays Gastric Emptying and Decreases Fecal Water Content in Dogs withTotal Colectomy

2002 • 17 citations