Evidence for Central Nervous System Insulin Synthesis

THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPT

1969 • 1,680 citations

Peptidergic neurones

1980 • 1,523 citations

Insulin receptors are widely distributed in the central nervous system of the rat

1978 • 1,092 citations

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

1979 • 1,089 citations

Identification of insulin in rat brain.

1978 • 599 citations

Concentrations of Insulin and of Insulin Receptors in the Brain are Independent of Peripheral Insulin Levels

1979 • 324 citations

Insulin receptors and insulin modulation of norepinephrine uptake in neuronal cultures from rat brain.

1985 • 195 citations

Insulin acting as a modulator of feeding through the hypothalamus

1981 • 188 citations

Coexistence of peptides and putative transmitters in neurons.

1980 • 188 citations

Effect of insulin on central catecholamines

1983 • 186 citations

Insulin-Mediated Regulation of Neuronal Maturation

1984 • 184 citations

Insulin inhibits pyramidal neurons in hippocampal slices

1984 • 176 citations

Insulin Is Released from Rat Brain Neuronal Cells in Culture

1986 • 175 citations

Binding and Internalization of Insulin and Insulin-Like Growth Factors by Isolated Brain Microvessels

1986 • 165 citations

Periventricular hypothalamic cells in the rat brain contain insulin mRNA

1986 • 143 citations

Insulin is ubiquitous in extrapancreatic tissues of rats and humans.

1980 • 140 citations

Genetically obese zucker rats have abnormally low brain insulin content

1985 • 140 citations

Localization of insulin-like immunoreactivity in the neurons from primary cultures of rat brain

1983 • 115 citations

Effect of Intracisternal Insulin on Plasma Glucose and Insulin in the Dog

1975 • 79 citations

Guinea pig preproinsulin gene: an evolutionary compromise?

1984 • 78 citations

IMMUNOREACTIVE INSULIN LEVELS ARE ELEVATED IN THE CEREBROSPINAL FLUID OF GENETICALLY OBESE ZUCKER RATS

1983 • 75 citations

Evaluation of rat insulin messenger RNA in pancreatic and extrapancreatic tissues

1985 • 68 citations

Insulin Recoverable from Tissues

1980 • 61 citations

Insulin stimulates macromolecular synthesis in cultured glial cells from rat brain

1985 • 55 citations

Influence of the insulin sensitive central nervous system glucoregulator receptor on hepatic glucose metabolism.

1975 • 51 citations

Binding and internalization of insulin and insulin-like growth factors by isolated brain microvessels

1986 • 51 citations

Proinsulin‐like material in mouse foetal brain cell cultures

1984 • 44 citations

Insulin immunohistochemistry of rodent CNS: Apparent species differences but good correlation with radioimmunological data

1981 • 40 citations

Insulin and C-peptide in human brain neurons (insulin/C-peptide/brain peptides/immunohistochemistry/radioimmunoassay).

1983 • 36 citations

Influence of the age of erythrocytes on their insulin receptors

1980 • 32 citations

Further Evidence for Non-Pancreatic Insulin Immunoreactivity in Guinea Pig Brain

1983 • 26 citations

Is insulin a neuromodulator?

1982 • 26 citations

Effect of intracisternal insulin on plasma glucose and insulin in the dog

1975 • 24 citations

Insulin in the extrapancreatic tissues of guinea pigs differs markedly from the insulin in their pancreas and plasma.

1980 • 14 citations

Two distinct insulin-related molecules in the guinea pig: immunological and biochemical characterization of insulin-like immunoactivity from extrapancreatic tissues of the guinea pig

1985 • 11 citations

1202 TRANSCRIPTION OF THE INSULIN GENE IN THE BRAIN AND SUBMANDIBULAR GLAND OF THE RAT

1985 • 6 citations