Cutaneous Immunomodulation and Coordination of Skin Stress Responses by α‐Melanocyte‐Stimulating Hormone^a

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor

1994 • 1,055 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Molecular cloning, expression, and gene localization of a fourth melanocortin receptor

1993 • 844 citations

The syntax of immune-neuroendocrine communication

1994 • 720 citations

Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA

1992 • 595 citations

Neuroendocrine-Immune Interactions

1993 • 571 citations

Neuroendocrinology and Pathophysiology of the Stress System

1995 • 530 citations

Neuroendocrine-Immune System Interactions and Autoimmunity

1995 • 460 citations

Proopiomelanocortin-derived peptides are synthesized and released by human keratinocytes.

1994 • 341 citations

Interactions Between the Brain and the Immune System

1990 • 330 citations

Molecular Cloning, Expression, and Characterization of a Fifth Melanocortin Receptor

1994 • 305 citations

Corticotropin-Releasing Hormone in Humans*

1992 • 283 citations

Evidence of autocrine modulation of macrophage nitric oxide synthase by alpha-melanocyte-stimulating hormone.

1995 • 282 citations

Alpha melanocyte stimulating hormone inhibits immunostimulatory and inflammatory actions of interleukin 1.

1986 • 221 citations

Molecular Cloning of a Mouse Melanocortin 5 Receptor Gene Widely Expressed in Peripheral Tissues

1994 • 212 citations

α-Melanocyte Stimulating Hormone in the Modulation of Host Reactions*

1993 • 201 citations

ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

1996 • 201 citations

Pro-opiomelanocortin-derived peptides induce IL-10 production in human monocytes.

1996 • 197 citations

Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line.

1996 • 196 citations

Antipyretic Potency of Centrally Administered α-Melanocyte Stimulating Hormone

1983 • 166 citations

MSH peptides are present in mammalian skin

1983 • 161 citations

α-MSH production, receptors, and influence on neopterin in a human monocyte/macrophage cell line

1996 • 160 citations

Detection of proopiomelanocortin-derived antigens in normal and pathologic human skin.

1993 • 160 citations

Evidence for the differential expression of the functional alpha-melanocyte-stimulating hormone receptor MC-1 on human monocytes.

1997 • 156 citations

Melanocytes as "Sensory" and Regulatory Cells in the Epidermis

1993 • 156 citations

alpha-Melanocyte-stimulating hormone induces hapten-specific tolerance in mice.

1996 • 153 citations

Proprotein conversion is determined by a multiplicity of factors including convertase processing, substrate specificity, and intracellular environment. Cell type-specific processing of human prorenin by the convertase PC1.

1992 • 149 citations

The neuroendocrine polypeptide 7B2 is an endogenous inhibitor of prohormone convertase PC2.

1994 • 141 citations

Alpha-melanocyte-stimulating hormone reduces endotoxin-induced liver inflammation.

1996 • 140 citations

On the potential role of proopiomelanocortin in skin physiology and pathology

1993 • 135 citations

Human dermal microvascular endothelial cells express the melanocortin receptor type 1 and produce increased levels of IL-8 upon stimulation with alpha-melanocyte-stimulating hormone.

1997 • 134 citations

The Role of α-Melanocyte-Stimulating Hormone in Cutaneous Biology

1997 • 131 citations

Hormonal Regulation Of POMC Gene Expression

1989 • 130 citations

Proopiomelanocortin, Its Derived Peptides, and the Skin

1996 • 128 citations

Ultraviolet B and Melanocyte-Stimulating Hormone (MSH) Stimulate mRNA Production for ∝MSH Receptors and Proopiomelanocortin-Derived Peptides in Mouse Melanoma Cells and Transformed Keratinocytes

1995 • 118 citations

Proopiomelanocortin expression in the skin during induced hair growth in mice

1992 • 118 citations

Stress : basic mechanisms and clinical implications

1995 • 109 citations

The Neuropeptide Alpha-Melanocyte-Stimulating Hormone Inhibits Experimental Arthritis in Rats

1994 • 104 citations

ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin

1996 • 99 citations

α Melanocyte stimulating hormone (αmsh) stimulates normal human melanocyte growth by binding to high-affinity receptors

1993 • 97 citations

Alpha-melanocyte-stimulating hormone exhibits target cell selectivity in its capacity to affect interleukin 1-inducible responses in vivo and in vitro.

1987 • 92 citations

Characterization of melanocortin receptor subtype expression in murine adipose tissues and in the 3T3-L1 cell line

1996 • 89 citations

Homologous and heterologous regulation of alpha-melanocyte-stimulating hormone receptors in human and mouse melanoma cell lines.

1994 • 88 citations

Alpha-Melanocyte-Stimulating Hormone Suppresses Antigen-Stimulated T Cell Production of Gamma-lnterferon

1994 • 87 citations

Immunosuppressive effects of corticotropin and melanotropin and their possible significance in human immunodeficiency virus infection.

1992 • 83 citations

Alpha-Melanocyte Stimulating Hormone Modulates Contact Hypersensitivity Responsiveness in C57/BL6 Mice

1989 • 82 citations

Central administration of the peptide α-MSH inhibits inflammation in the skin

1991 • 79 citations

Control of Melanocyte Proliferation and Differentiation in the Mouse Epidermis

1992 • 77 citations

Corticotropin-Releasing Factor Differentially Regulates Anterior and Intermediate Pituitary Lobe Proopiomelanocortin Gene Transcription, Nuclear Precursor RNA and Mature mRNA in vivo

1990 • 75 citations

Neuropeptide α-MSH antagonizes IL-6- and TNF-induced fever

1991 • 74 citations

α-MSH peptides inhibit acute inflammation induced in mice by rIL-1β, rIL-6, rTNF-α and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8

1992 • 70 citations

alpha-Melanocyte stimulating hormone in the modulation of host reactions

1993 • 70 citations

Combinatorial diffusion assay used to identify topically active melanocyte-stimulating hormone receptor antagonists.

1995 • 67 citations

Production of POMC, CRH-R1, MC1, and MC2 Receptor mRNA and Expression of Tyrosinase Gene in Relation to Hair Cycle and Dexamethasone Treatment in the C57BL/6 Mouse Skin

1997 • 66 citations

Localization of the Genes Encoding the Melanocortin-2 (Adrenocorticotropic Hormone) and Melanocortin-3 Receptors to Chromosomes 18p11.2 and 20q13.2-q13.3 by Fluorescence in Situ Hybridization

1993 • 60 citations

The Melanotropic peptides

1993 • 59 citations

Production of Immunosuppressing Melanotropins By Human Keratinocytes^a

1993 • 59 citations

Alpha-Melanocyte-Stimulating Hormone Immunoreactivity in Melanoma Cells

1990 • 56 citations

Effect of PUVA on plasma and skin immunoreactive α-melanocyte stimulating hormone concentrations

1987 • 56 citations

The influence of endorphins on peritoneal and mucosal mast cell secretion

1984 • 56 citations

Neuropeptides are potent modulators of human in vitro immunoglobulin E synthesis

1994 • 55 citations

α-melanocyte-stimulating hormone reduces interleukin-lβ effects on rat stomach preparations possibly through interference with a type I receptor

1991 • 55 citations

Adrenocorticotropin Stimulates Natural Killer Cell Activity*

1991 • 52 citations

Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids

1989 • 51 citations

The Anticytokine Neuropeptide α-Melanocyte-Stimulating Hormone in Synovial Fluid of Patients with Rheumatic Diseases: Comparisons with Other Anticytokine Molecules

1994 • 51 citations

The Discovery of the Melanotropins: A History of Pituitary Endocrinology^a

1993 • 48 citations

AGOUTI PROTEIN CAN ACT INDEPENDENTLY OF MELANOCYTE-STIMULATING HORMONE TO INHIBIT MELANOGENESIS

1995 • 45 citations

α-Melanocyte Stimulating Hormone Induces Collagenase/Matrix Metalloproteinase-1 in Human Dermal Fibroblasts

1995 • 42 citations

Increased concentration of beta-endorphin in the sera of patients with severe atopic dermatitis.

1995 • 41 citations

Increased concentration of beta-endorphin in sera of patients with psoriasis and other inflammatory dermatoses

2006 • 41 citations

Modulation of natural killer cell-mediated lysis by corticotropin-releasing neurohormone

1991 • 40 citations

The cDNA structure of the porcine pro‐hormone convertase PC2 and the comparative processing by PC1 and PC2 of the N‐terminal glycopeptide segment of porcine POMC

1992 • 39 citations

Propiomelanocortin (POMC) gene expression by normal skin and keloid fibroblasts in culture: modulation by cytokines

1997 • 38 citations

[Modification of alpha-MSH by UVA irradiation of the skin].

1983 • 33 citations

Cellular Communication Networks Implications for Our Understanding of Gastrointestinal Physiologya

1992 • 32 citations

Evidence for γ-Melanocyte Stimulating Hormone Containing Nerves and Neutrophilic Granulocytes in the Human Skin by Indirect Immunofluorescence

1990 • 28 citations

Degradation of alpha‐melanocyte stimulating hormone (alpha‐MSH) by CALLA/endopeptidase 24. 11 expressed by human melanoma cells in culture

1990 • 26 citations

Plasma Concentration of Cytokine Antagonists in Patients with HIV Infection

1994 • 25 citations

Neuroimmunophysiology of the gastrointestinal mucosa: implications for inflammatory diseases.

1995 • 24 citations

Neuroendocrine Functions of Histamine

1991 • 18 citations

Proopiomelanocortin-derived peptides as tools of immune evasion for the human trematode Schistosoma mansoni.

1992 • 16 citations

Effect of tunicamycin on biosynthesis, processing and release of proopiomelanocortin-derived peptides in the intermediate lobe of the frog Rana ridibunda

1986 • 16 citations

The effect of adrenocorticotropin on histamine and 5-hydroxytryptamine secretion from rat mast cells

1984 • 11 citations

γ‐melanocyte stimulating hormone (γ‐MSH)‐like immunoreactivity is present in certain normal human keratinocytes

1993 • 11 citations

Zur diagnostischen Bedeutung des ?-MSH beim malignen Melanom des Menschen

1994 • 9 citations

Relevance of alpha-MSH plasma levels to diagnosis in human malignant melanoma

1994 • 8 citations

Cytokine Neuropeptide Interactions in the Skin

1994 • 4 citations

Modulation of Prohormone Convertase mRNA by Second Messenger Activators and Drugs

1996 • 3 citations