Neuronal stress and injury in C57/BL mice after systemic kainic acid administration

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

THE HEAT-SHOCK RESPONSE

1986 • 4,580 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Speculations on the functions of the major heat shock and glucose-regulated proteins

1986 • 1,574 citations

Multiple Calcium Channels and Neuronal Function

1987 • 1,336 citations

Excitatory amino acid receptors in the vertebrate central nervous system.

1989 • 1,316 citations

Interaction of Hsp 70 with Newly Synthesized Proteins: Implications for Protein Folding and Assembly

1990 • 1,293 citations

Mammalian stress response: cell physiology, structure/function of stress proteins, and implications for medicine and disease

1992 • 1,201 citations

‘Ischemic tolerance’ phenomenon found in the brain

1990 • 1,098 citations

Glutamate neurotoxicity in cortical cell culture is calcium dependent

1985 • 818 citations

Stress proteins in biology and medicine

1990 • 731 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

Heat Shock Is Lethal to Fibroblasts Microinjected with Antibodies Against hsp70

1988 • 635 citations

Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones.

1990 • 498 citations

Induced thermal resistance in HeLa cells

1975 • 494 citations

Localization of 70-kDa stress protein induction in gerbil brain after ischemia

1988 • 465 citations

AMPA and kainate receptors

1995 • 460 citations

The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy

1994 • 460 citations

Hyperthermia Protects Against Light Damage in the Rat Retina

1988 • 445 citations

Excitatory amino acids activate calpain I and induce structural protein breakdown in vivo

1988 • 437 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage

1989 • 359 citations

Non-NMDA and NMDA receptor-mediated excitotoxic neuronal deaths in adult brain are morphologically distinct: Further evidence for an apoptosis-necrosis continuum

1997 • 339 citations

Excitotoxic neuronal death in the immature brain is an apoptosis-necrosis morphological continuum

1997 • 333 citations

Competitive Inhibition of hsp70 Gene Expression Causes Thermosensitivity

1988 • 319 citations

Heat shock proteins as markers of neural injury

1989 • 304 citations

Kainic acid neurotoxicity toward hippocampal formation: Dependence on specific excitatory pathways

1980 • 286 citations

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

1987 • 280 citations

Glutamate triggers internucleosomal DNA cleavage in neuronal cells

1991 • 276 citations

1 The Stress Response, Function of the Proteins, and Perspectives

1990 • 271 citations

Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

1985 • 270 citations

Protection of rat hippocampus against ischemic neuronal damage by pretreatment with sublethal ischemia

1992 • 247 citations

Temporal lobe epilepsy caused by domoic acid intoxication: Evidence for glutamate receptor–mediated excitotoxicity in humans

1995 • 224 citations

The temporal profile of 72-kDa heat-shock protein expression following global ischemia

1991 • 206 citations

Heat shock protects cultured neurons from glutamate toxicity

1991 • 199 citations

Induction of a heat shock gene at the site of tissue injury in the rat brain

1989 • 183 citations

Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat

1989 • 179 citations

A transient thermotolerant survival response produced by single thermal doses in HeLa cells.

1976 • 174 citations

Comparative toxicity of kainic acid and other acidic amino acids toward rat hippocampal neurons

1981 • 160 citations

Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice

1996 • 157 citations

The pattern of 72-kDa heat shock protein-like immunoreactivity in the rat brain following flurothyl-induced status epilepticus

1990 • 139 citations

Genetic correlations among inbred strain sensitivities to convulsions induced by 9 convulsant drugs

1990 • 129 citations

Transcription of the Human HSP70 Gene: cis-Acting Elements and trans-Acting Factors Involved in Basal, Adenovirus E1A, and Stress-Induced Expression

1990 • 120 citations

Distribution of the 72-kd heat-shock protein as a function of transient focal cerebral ischemia in rats.

1992 • 100 citations

Internucleosomal DNA fragmentation in gerbil hippocampus following forebrain ischemia

1994 • 84 citations

DNA Fragmentation and Prolonged Expression of c-fos, c-jun, and hsp70 in Kainic Acid-Induced Neuronal Cell Death in Transgenic Mice Overexpressing Human CuZn-Superoxide Dismutase

1997 • 81 citations

Epileptic tolerance: prior seizures protect against seizure-induced neuronal injury

1995 • 81 citations

Anatomical studies of DNA fragmentation in rat brain after systemic kainate administration

1996 • 71 citations

Stereotaxic injection of kainic acid into the striatum of rats induces synthesis of mRNA for heat shock protein 70

1988 • 63 citations

Inhibition of the heat shock response and synthesis of glucose-regulated proteins in Ca 2+ -deprived rat hepatoma cells

1985 • 62 citations

Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons

1994 • 49 citations

Distribution of HSP72 induction and neuronal death following limbic seizures

1992 • 41 citations

Strain differences in convulsive response to the excitotoxin kainic acid

1991 • 39 citations

8. The relationship between electrographic seizure activity and neuronal injury

1991 • 24 citations

Genetic influences on cellular reactions to brain injury: Activation of microglia in denervated neuropil in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration

1997 • 23 citations

Correlation between electroconvulsive seizure and HSC70 mRNA induction in mice brain

1993 • 23 citations

DNA Fragmentation and Immediate Early Gene Expression in Rat Striatum Following Quinolinic Acid Administration

1995 • 20 citations

Heat shock proteins protect cultured fibroblasts from the cytotoxic effects of MPP+

1996 • 17 citations

The pattern of neuronal injury following seizures induced by intranigral kainic acid

1994 • 16 citations