Life, death and membrane bilayers

Free radicals in biology and medicine

1991 • 17,840 citations

Aging: A Theory Based on Free Radical and Radiation Chemistry

1956 • 8,252 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Cellular energy utilization and molecular origin of standard metabolic rate in mammals

1997 • 1,855 citations

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain

2002 • 1,500 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Thermal Adaptation in Biological Membranes: Is Homeoviscous Adaptation the Explanation?

1995 • 1,186 citations

Metabolism of highly unsaturated n-3 and n-6 fatty acids

2000 • 825 citations

The lipid world.

2001 • 569 citations

Mammalian Aging, Metabolism, and Ecology: Evidence From the Bats and Marsupials

1991 • 450 citations

Polyunsaturated Fatty Acids in Lipid Bilayers: Intrinsic and Environmental Contributions to Their Unique Physical Properties

2001 • 439 citations

Mechanisms Underlying the Cost of Living in Animals

2000 • 390 citations

Initial indications of abiotic formation of hydrocarbons in the Rainbow ultramafic hydrothermal system, Mid-Atlantic Ridge

2001 • 335 citations

Recent advances in the biochemistry and molecular biology of fatty acyl desaturases

1998 • 306 citations

Membranes as Possible Pacemakers of Metabolism

1999 • 305 citations

Evolution of energy metabolism. Proton permeability of the inner membrane of liver mitochondria is greater in a mammal than in a reptile

1991 • 280 citations

A role for phospholipid polyunsaturation in modulating membrane protein function

1996 • 280 citations

Characteristics of mitochondrial proton leak and control of oxidative phosphorylation in the major oxygen-consuming tissues of the rat

1994 • 245 citations

Significance of cation transport in control of energy metabolism and thermogenesis.

1991 • 241 citations

Comparison of mitochondrial pro-oxidant generation and anti-oxidant defenses between rat and pigeon: possible basis of variation in longevity and metabolic potential

1993 • 234 citations

The Proton Permeability of the Inner Membrane of Liver Mitochondria from Ectothermic and Endothermic Vertebrates and from Obese Rats: Correlations with Standard Metabolic Rate and Phospholipid Fatty Acid Composition

1998 • 230 citations

Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals

1998 • 225 citations

Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition

1996 • 207 citations

Birds as Animal Models for the Comparative Biology of Aging: A Prospectus

1995 • 182 citations

Evolution of mammalian endothermic metabolism: "leaky" membranes as a source of heat

1987 • 146 citations

Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case

1996 • 139 citations

Anti-lipoperoxidation action of food restriction

1987 • 139 citations

The acyl composition of mammalian phospholipids: an allometric analysis

2002 • 134 citations

Lipids and their effects on membrane proteins: Evidence against a role for fluidity

1991 • 126 citations

Causes of differences in respiration rate of hepatocytes from mammals of different body mass

1995 • 126 citations

Effect of docosahexaenoic acid on mouse mitochondrial membrane properties

1997 • 117 citations

Relationship between body mass, tissue metabolic rate, and sodium pump activity in mammalian liver and kidney

1995 • 114 citations

What role for membranes in determining the higher sodium pump molecular activity of mammals compared to ectotherms?

1999 • 114 citations

Acyl composition of muscle membranes varies with body size in birds

2002 • 111 citations

Low Fatty Acid Unsaturation: A Mechanism for Lowered Lipoperoxidative Modification of Tissue Proteins in Mammalian Species With Long Life Spans

2000 • 88 citations

The effect of temperature acclimation upon succinic dehydrogenase activity from the epaxial muscle of the common goldfish (Carassius auratus L.)—II. Lipid reactivation of the soluble enzyme

1972 • 87 citations

Molecular activity of Na+/K+-ATPase from different sources is related to the packing of membrane lipids

2001 • 86 citations

High levels of docosahexaenoic acid (22:6n-3)-containing phospholipids in high-frequency contraction muscles of hummingbirds and rattlesnakes

2001 • 75 citations

Molecular activity of sodium pumps in endotherms and ectotherms

1996 • 73 citations

Homeoviscous adaptation and thermal compensation of sodium pump of trout erythrocytes

1991 • 67 citations

Proton leak in hepatocytes and liver mitochondria from archosaurs (crocodiles) and allometric relationships for ectotherms

2002 • 64 citations

Generation and Remodeling of Phospholipid Molecular Species in Rat Hepatocytes

1995 • 58 citations

Effect of dietary restriction on age‐related increase of liver susceptibility to peroxidation in rats

2001 • 49 citations

Lipid metabolism in prokaryotes

1996 • 45 citations

The evolution of lipids

2001 • 42 citations

Turnover of phospholipid fatty acyl chains in cultured neuroblastoma cells: involvement of deacylation-reacylation and de novo synthesis in plasma membranes

1986 • 41 citations

Varying incorporation of fatty acids into phospholipids from muscle, adipose and pancreatic exocrine tissues and thymocytes in adult rats fed with diets rich in different fatty acids.

2000 • 40 citations

Formation of Vesicles by the Action of Acyl-CoA:1-Acyllysophosphatidylcholine Acyltransferase from Rat Liver Microsomes: Optimal Solubilization Conditions and Analysis of Lipid Composition and Enzyme Activity

1996 • 27 citations

Chronic caloric restriction alters muscle membrane fatty acid content☆

2000 • 26 citations

Assessment of lipid peroxidation in rats of different body weight by determining expired ethane.

1995 • 8 citations