Improvements in recanalization with modern stroke therapy: a review of prospective ischemic stroke trials during the last two decades

Tissue Plasminogen Activator for Acute Ischemic Stroke

1995 • 10,997 citations

Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke

2008 • 6,061 citations

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

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The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

Intra-arterial Prourokinase for Acute Ischemic Stroke

1999 • 3,037 citations

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials

2010 • 2,024 citations

Safety and Efficacy of Mechanical Embolectomy in Acute Ischemic Stroke

2005 • 1,315 citations

Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial

2012 • 1,282 citations

Mechanical Thrombectomy for Acute Ischemic Stroke

2008 • 1,219 citations

Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial

2012 • 1,078 citations

The Penumbra Pivotal Stroke Trial

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Intra-arterial Prourokinase for Acute Ischemic Stroke

2000 • 793 citations

Combined Intravenous and Intra-Arterial Recanalization for Acute Ischemic Stroke: The Interventional Management of Stroke Study

2004 • 736 citations

The Interventional Management of Stroke (IMS) II Study

2007 • 618 citations

The Importance of Size

2011 • 548 citations

Good clinical outcome after ischemic stroke with successful revascularization is time-dependent

2009 • 482 citations

Recombinant Tissue-Type Plasminogen Activator Use for Ischemic Stroke in the United States

2011 • 459 citations

Comparison of intravenous alteplase with a combined intravenous–endovascular approach in patients with stroke and confirmed arterial occlusion (RECANALISE study): a prospective cohort study

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Methodology of the Interventional Management of Stroke III Trial

2008 • 265 citations

First Food and Drug Administration-Approved Prospective Trial of Primary Intracranial Stenting for Acute Stroke

2009 • 230 citations

Revascularization End Points in Stroke Interventional Trials

2005 • 229 citations

Rescue, Combined, and Stand-Alone Thrombectomy in the Management of Large Vessel Occlusion Stroke Using the Solitaire Device: A Prospective 50-Patient Single-Center Study

2011 • 188 citations

Quantification of Thrombus Hounsfield Units on Noncontrast CT Predicts Stroke Subtype and Early Recanalization after Intravenous Recombinant Tissue Plasminogen Activator

2011 • 133 citations

Midterm Clinical and Angiographic Follow-Up for the First Food and Drug Administration-Approved Prospective, Single-Arm Trial of Primary Stenting for Stroke: SARIS (Stent-Assisted Recanalization for Acute Ischemic Stroke)

2011 • 61 citations