Dependence of Epistasis on Environment and Mutation Severity as Revealed by in Silico Mutagenesis of Phage T7

The relation of recombination to mutational advance

1964 • 2,547 citations

Classification of Hypotheses on the Advantage of Amphimixis

1993 • 591 citations

Epistasis and the Evolutionary Process

2000 • 563 citations

THE MUTATIONAL LOAD WITH EPISTATIC GENE INTERACTIONS IN FITNESS

1966 • 523 citations

MULTIPLE FITNESS PEAKS AND EPISTASIS

1995 • 506 citations

MUTATION RATE AND DOMINANCE OF GENES AFFECTING VIABILITY IN DROSOPHILA MELANOGASTER

1972 • 494 citations

The accumulation of deleterious genes in a population—Muller's Ratchet

1978 • 490 citations

Test of synergistic interactions among deleterious mutations in bacteria

1997 • 432 citations

Mutation-selection balance and the evolutionary advantage of sex and recombination

1990 • 411 citations

Genetic Loads and the Cost of Natural Selection

1970 • 332 citations

Genome complexity, robustness and genetic interactions in digital organisms

1999 • 317 citations

No syringes please, ejection of phage T7 DNA from the virion is enzyme driven

2001 • 211 citations

Direct Estimate of the Mutation Rate and the Distribution of Fitness Effects in the Yeast Saccharomyces cerevisiae

2001 • 180 citations

Effects ofEscherichia coliPhysiology on Growth of Phage T7 In Vivo and In Silico

2002 • 160 citations

THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. VII SYNERGISTIC INTERACTION OF SPONTANEOUS MUTANT POLYGENES CONTROLLING VIABILITY

1969 • 159 citations

High Frequency of Cryptic Deleterious Mutations in Caenorhabditis elegans

1999 • 155 citations

FACTORS AFFECTING THE GENETIC LOAD IN DROSOPHILA: SYNERGISTIC EPISTASIS AND CORRELATIONS AMONG FITNESS COMPONENTS

2000 • 145 citations

New estimates of the rates and effects of mildly deleterious mutation in Drosophila melanogaster

1999 • 134 citations

Computation, prediction, and experimental tests of fitness for bacteriophage T7 mutants with permuted genomes

2000 • 125 citations

Test of Interaction Between Genetic Markers That Affect Fitness in Aspergillus niger

1997 • 124 citations

Intracellular kinetics of a growing virus: A genetically structured simulation for bacteriophage T7

1997 • 119 citations

Interaction between directional epistasis and average mutational effects

2001 • 114 citations

An Experimental Test for Synergistic Epistasis and Its Application in Chlamydomonas

1997 • 92 citations

The effect of sex and deleterious mutations on fitness in Chlamydomonas

1996 • 67 citations

TEST OF INTERACTION BETWEEN GENETIC MARKERS THAT AFFECT FITNESS INASPERGILLUS NIGER

1997 • 65 citations

Testing for Epistasis Between Deleterious Mutations

1998 • 61 citations

A Test for Epistasis Among Induced Mutations in Caenorhabditis elegans

2000 • 58 citations

Mutation and sex in a competitive world

2000 • 54 citations

GENETICS OF NATURAL POPULATIONS. XXXVI. EPISTATIC INTERACTIONS OF THE COMPONENTS OF THE GENETIC LOAD IN DROSOPHILA PSEUDOOBSCURA

1965 • 53 citations

Epistatic interactions of spontaneous mutations in haploid strains of the yeast Saccharomyces cerevisiae

2001 • 39 citations

Synergistic epistasis between loci affecting fitness: evidence in plants and fungi

1998 • 37 citations

Patterns of Regulation from mRNA and Protein Time Series

2000 • 34 citations

Population genetics: Surviving under mutation pressure

1998 • 27 citations

SIMULATING THE GROWTH OF VIRUSES

2000 • 10 citations