DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Genome maintenance mechanisms for preventing cancer

2001 • 3,819 citations

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

2001 • 1,147 citations

Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination

2002 • 1,118 citations

XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

2006 • 750 citations

Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

2002 • 462 citations

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

2007 • 387 citations

Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

2003 • 317 citations

DNA-PK autophosphorylation facilitates Artemis endonuclease activity

2006 • 316 citations

Cell Cycle Dependence of DNA-dependent Protein Kinase Phosphorylation in Response to DNA Double Strand Breaks

2005 • 312 citations

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

1999 • 295 citations

Ataxia Telangiectasia Mutated (ATM) Is Essential for DNA-PKcs Phosphorylations at the Thr-2609 Cluster upon DNA Double Strand Break

2006 • 284 citations

Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice

2005 • 267 citations

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

2006 • 254 citations

Role of DNA–PK in the cellular response to DNA double-strand breaks

2004 • 218 citations

The mechanism of non-homologous end-joining: a synopsis of synapsis

2004 • 217 citations

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

2002 • 188 citations

trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining

2007 • 182 citations

The DNA-dependent Protein Kinase Catalytic Subunit Phosphorylation Sites in Human Artemis

2005 • 140 citations

Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends

2004 • 138 citations

ATR-Dependent Phosphorylation of DNA-Dependent Protein Kinase Catalytic Subunit in Response to UV-Induced Replication Stress

2006 • 126 citations

The DNA-Dependent Protein Kinase Catalytic Subunit Is Phosphorylated In Vivo on Threonine 3950, a Highly Conserved Amino Acid in the Protein Kinase Domain

2006 • 124 citations

The role of DNA dependent protein kinase in synapsis of DNA ends

2003 • 122 citations

The two edges of the ATM sword: Co-operation between repair and checkpoint functions

2005 • 76 citations