Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR) ‐dependent signaling

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

1992 • 4,631 citations

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics.

2000 • 1,430 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

HMEC-1: Establishment of an Immortalized Human Microvascular Endothelial Cell Line

1992 • 1,258 citations

Hypoxia-inducible factor 1: master regulator of O2 homeostasis

1998 • 1,066 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation

1999 • 928 citations

Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP

1996 • 881 citations

Liver Organogenesis Promoted by Endothelial Cells Prior to Vascular Function

2001 • 857 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop

1990 • 756 citations

Signal transduction via platelet-derived growth factor receptors

1998 • 735 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: implications for tumor angiogenesis.

1995 • 598 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

Localization of PDGF-B Protein in Macrophages in All Phases of Atherogenesis

1990 • 584 citations

Cellular Mechanism of Oxygen Sensing

2001 • 548 citations

Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C

1993 • 523 citations

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

1997 • 501 citations

TOR signalling and control of cell growth

1997 • 458 citations

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors.

1994 • 428 citations

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

1998 • 365 citations

Biological consequences of tumor hypoxia

2001 • 343 citations

Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro

1999 • 325 citations

Bifurcation of Lipid and Protein Kinase Signals of PI3Kγ to the Protein Kinases PKB and MAPK

1998 • 310 citations

Endothelial cell hyperplasia in human glioblastoma: coexpression of mRNA for platelet-derived growth factor (PDGF) B chain and PDGF receptor suggests autocrine growth stimulation.

1988 • 288 citations

Evidence of Hypoxic Areas Within the Arterial Wall In Vivo

1999 • 278 citations

Mammalian Target of Rapamycin Pathway Regulates Insulin Signaling via Subcellular Redistribution of Insulin Receptor Substrate 1 and Integrates Nutritional Signals and Metabolic Signals of Insulin

2001 • 251 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.

1999 • 211 citations

Smooth Muscle Cells Isolated From Discrete Compartments of the Mature Vascular Media Exhibit Unique Phenotypes and Distinct Growth Capabilities

1997 • 208 citations

Cyclin D1 Expression Mediated by Phosphatidylinositol 3-Kinase through mTOR-p70^S6K-Independent Signaling in Growth Factor-Stimulated NIH 3T3 Fibroblasts

1999 • 179 citations

Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells

1996 • 170 citations

Characterization of S6K2, a novel kinase homologous to S6K1

1999 • 158 citations

Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver

2001 • 154 citations

Modulation of platelet-derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis.

1994 • 152 citations

Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells.

1995 • 133 citations

Hypoxia-induced Proliferative Response of Vascular Adventitial Fibroblasts Is Dependent on G Protein-mediated Activation of Mitogen-activated Protein Kinases

2001 • 120 citations

Evidence for the Involvement of Diacylglycerol Kinase in the Activation of Hypoxia-inducible Transcription Factor 1 by Low Oxygen Tension

2001 • 109 citations

Oxygen consumption in aortic tissue from rabbits with diet-induced atherosclerosis.

1987 • 89 citations

Brief exposure to hypoxia induces bFGF mRNA and protein and protects rat cortical neurons from prolonged hypoxic stress

1995 • 70 citations

PDGF-BB increases endothelial migration on cord movements during angiogenesis in vitro.

1997 • 69 citations

PDGF-BB increases endothelial migration and cord movements during angiogenesis in vitro

1997 • 55 citations

A Method for the Assessment of Hypoxia in the Arterial Wall, With Potential Application In Vivo

1996 • 27 citations

Platelet-Derived Growth Factor and Angiogenesis.

1996 • 23 citations

Control of vascular smooth muscle and endothelial cell proliferation and its implication in cardiovascular disease

1998 • 18 citations

Sirolimus-coated Stent Prevents Neointimal Proliferation.

2001 • 5 citations

Hypoxia Stimulates Proliferation of a Unique Cell Population Isolated From the Bovine Vascular Media

1998 • 4 citations