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Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases Society of America

Data up to Jan 2025

Published2008
Citations2,642
References315

Total Citations Per Year

Abstract

References (315)

Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis

2002 • 3,189 citations

Defining Opportunistic Invasive Fungal Infections in Immunocompromised Patients with Cancer and Hematopoietic Stem Cell Transplants: An International Consensus

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2002 Guidelines for the Use of Antimicrobial Agents in Neutropenic Patients with Cancer

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Posaconazole vs. Fluconazole or Itraconazole Prophylaxis in Patients with Neutropenia

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Invasive Aspergillosis

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Aspergillosis Case-Fatality Rate: Systematic Review of the Literature

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Posaconazole or Fluconazole for Prophylaxis in Severe Graft-versus-Host Disease

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Liposomal Amphotericin B for Empirical Therapy in Patients with Persistent Fever and Neutropenia

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Echinocandin antifungal drugs

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THE SPECTRUM OF THE DISEASE IN 98 PATIENTS

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Voriconazole Compared with Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Neutropenia and Persistent Fever

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Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors

2002 • 949 citations

Antifungal and Surgical Treatment of Invasive Aspergillosis: Review of 2,121 Published Cases

1990 • 918 citations

Caspofungin versus Liposomal Amphotericin B for Empirical Antifungal Therapy in Patients with Persistent Fever and Neutropenia

2004 • 907 citations

Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia

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Efficacy and Safety of Voriconazole in the Treatment of Acute Invasive Aspergillosis

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Epidemiology ofAspergillusInfections in a Large Cohort of Patients Undergoing Bone Marrow Transplantation

1997 • 768 citations

Treatment of Invasive Aspergillosis with Posaconazole in Patients Who Are Refractory to or Intolerant of Conventional Therapy: An Externally Controlled Trial

2006 • 750 citations

Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis—State of the Art: Cystic Fibrosis Foundation Consensus Conference

2003 • 737 citations

Micafungin versus Fluconazole for Prophylaxis against Invasive Fungal Infections during Neutropenia in Patients Undergoing Hematopoietic Stem Cell Transplantation

2004 • 729 citations

Liposomal Amphotericin B as Initial Therapy for Invasive Mold Infection: A Randomized Trial Comparing a High-Loading Dose Regimen with Standard Dosing (AmBiLoad Trial)

2007 • 704 citations

Voriconazole Treatment for Less‐Common, Emerging, or Refractory Fungal Infections

2003 • 680 citations

Multicenter Clinical Evaluation of the (1->3) -D-Glucan Assay as an Aid to Diagnosis of Fungal Infections in Humans

2005 • 651 citations

Efficacy and Safety of Caspofungin for Treatment of Invasive Aspergillosis in Patients Refractory to or Intolerant of Conventional Antifungal Therapy

2004 • 651 citations

-D-Glucan as a Diagnostic Adjunct for Invasive Fungal Infections: Validation, Cutoff Development, and Performance in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome

2004 • 637 citations

Amphotericin B Lipid Complex for Invasive Fungal Infections: Analysis of Safety and Efficacy in 556 Cases

1998 • 631 citations

Galactomannan and Computed Tomography-Based Preemptive Antifungal Therapy in Neutropenic Patients at High Risk for Invasive Fungal Infection: A Prospective Feasibility Study

2005 • 592 citations

Increasing Volume and Changing Characteristics of Invasive Pulmonary Aspergillosis on Sequential Thoracic Computed Tomography Scans in Patients With Neutropenia

2001 • 574 citations

Imaging Findings in Acute Invasive Pulmonary Aspergillosis: Clinical Significance of the Halo Sign

2007 • 564 citations

Plasma (1→3)-β-D-glucan measurement in diagnosis of invasive deep mycosis and fungal febrile episodes

1995 • 533 citations

Allergic sinusitis: a newly recognized form of sinusitis

1983 • 532 citations

Screening for circulating galactomannan as a noninvasive diagnostic tool for invasive aspergillosis in prolonged neutropenic patients and stem cell transplantation recipients: a prospective validation

2001 • 522 citations

Chronic Cavitary and Fibrosing Pulmonary and Pleural Aspergillosis: Case Series, Proposed Nomenclature Change, and Review

2003 • 521 citations

A Randomized Trial of Itraconazole in Allergic Bronchopulmonary Aspergillosis

2000 • 508 citations

Itraconazole resistance in Aspergillus fumigatus

1997 • 500 citations

Detection of circulating galactomannan for the diagnosis and management of invasive aspergillosis

2004 • 481 citations

Detection of Galactomannan Antigenemia by Enzyme Immunoassay for the Diagnosis of Invasive Aspergillosis: Variables That Affect Performance

2004 • 473 citations

Risks and outcomes of invasive fungal infections in recipients of allogeneic hematopoietic stem cell transplants after nonmyeloablative conditioning

2003 • 471 citations

A randomized placebo-controlled phase III study of granulocyte- macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490)

1995 • 462 citations

NIAID mycoses study group multicenter trial of oral itraconazole therapy for invasive aspergillosis

1994 • 459 citations

Allergic bronchopulmonary aspergillosis

2002 • 451 citations

Invasive pulmonary aspergillosis in acute leukemia: characteristic findings on CT, the CT halo sign, and the role of CT in early diagnosis.

1985 • 450 citations

Mortality and Costs of Acute Renal Failure Associated with Amphotericin B Therapy

2001 • 444 citations

The Impact of Culture Isolation ofAspergillusSpecies: A Hospital‐Based Survey of Aspergillosis

2001 • 444 citations

Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children

2002 • 437 citations

Itraconazole versus fluconazole for prevention of fungal infections in patients receiving allogeneic stem cell transplants

2003 • 433 citations

The Epidemiological Features and Laboratory Results of Fungal Keratitis

2002 • 430 citations

AspergillusGalactomannan Detection in the Diagnosis of Invasive Aspergillosis in Cancer Patients

2002 • 398 citations

Voriconazole Therapeutic Drug Monitoring

2006 • 397 citations

Intravenous and Oral Itraconazole versus Intravenous and Oral Fluconazole for Long-Term Antifungal Prophylaxis in Allogeneic Hematopoietic Stem-Cell Transplant Recipients: A Multicenter, Randomized Trial

2003 • 391 citations

Safety, Tolerance, and Pharmacokinetics of High-Dose Liposomal Amphotericin B (AmBisome) in Patients Infected with Aspergillus Species and Other Filamentous Fungi: Maximum Tolerated Dose Study

2001 • 382 citations

Itraconazole to Prevent Fungal Infections in Chronic Granulomatous Disease

2003 • 377 citations

Improved outcome in central nervous system aspergillosis, using voriconazole treatment

2005 • 372 citations

Opportunistic Mycoses in the Immunocompromised Host: Experience at a Cancer Center and Review

1992 • 367 citations

Invasive Aspergillosis in Transplant Recipients

1999 • 365 citations

Clinical Significance of Nephrotoxicity in Patients Treated with Amphotericin B for Suspected or Proven Aspergillosis

1999 • 365 citations

Evaluation of a (1→3)-β- <scp>d</scp> -Glucan Assay for Diagnosis of Invasive Fungal Infections

2005 • 362 citations

Empiric antifungal therapy in febrile granulocytopenic patients

1989 • 360 citations

Use of Circulating Galactomannan Screening for Early Diagnosis of Invasive Aspergillosis in Allogeneic Stem Cell Transplant Recipients

2002 • 344 citations

Combination of Voriconazole and Caspofungin as Primary Therapy for Invasive Aspergillosis in Solid Organ Transplant Recipients: A Prospective, Multicenter, Observational Study

2006 • 336 citations

Pharmacokinetics and Safety of Intravenous Voriconazole in Children after Single- or Multiple-Dose Administration

2004 • 332 citations

Invasive Pulmonary Aspergillosis Associated with Infliximab Therapy

2001 • 332 citations

A new sensitive sandwich enzyme-linked immunosorbent assay to detect galactofuran in patients with invasive aspergillosis

1995 • 329 citations

A Double‐Blind, Randomized, Controlled Trial of Amphotericin B Colloidal Dispersion versus Amphotericin B for Treatment of Invasive Aspergillosis in Immunocompromised Patients

2002 • 323 citations

Liposomal amphotericin B compared with amphotericin B deoxycholate in the treatment of documented and suspected neutropenia‐associated invasive fungal infections

1998 • 321 citations

Intravenous and Oral Itraconazole versus Intravenous Amphotericin B Deoxycholate as Empirical Antifungal Therapy for Persistent Fever in Neutropenic Patients with Cancer Who Are Receiving Broad-Spectrum Antibacterial Therapy

2001 • 320 citations

The use of respiratory-tract cultures in the diagnosis of invasive pulmonary aspergillosis

1996 • 316 citations

Aspergillosis

2002 • 308 citations

Newer Systemic Antifungal Agents

2004 • 307 citations

Pharmacology of Systemic Antifungal Agents

2006 • 299 citations

Efficacy and toxicity of caspofungin in combination with liposomal amphotericin B as primary or salvage treatment of invasive aspergillosis in patients with hematologic malignancies

2003 • 292 citations

Micafungin (FK463), alone or in combination with other systemic antifungal agents, for the treatment of acute invasive aspergillosis

2006 • 292 citations

Infections Due to Aspergillus terreus: A Multicenter Retrospective Analysis of 83 Cases

2004 • 292 citations

Prospective Comparison of the Diagnostic Potential of Real-Time PCR, Double-Sandwich Enzyme-Linked Immunosorbent Assay for Galactomannan, and a (1→3)-β- <scp>d</scp> -Glucan Test in Weekly Screening for Invasive Aspergillosis in Patients with Hematological Disorders

2004 • 290 citations

Efficacy of Caspofungin Alone and in Combination with Voriconazole in a Guinea Pig Model of Invasive Aspergillosis

2002 • 286 citations

AspergillusGalactomannan Enzyme Immunoassay and Quantitative PCR for Diagnosis of Invasive Aspergillosis with Bronchoalveolar Lavage Fluid

2004 • 285 citations

Anti-inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: A randomized controlled trial

2003 • 283 citations

Aspergillus infections after lung transplantation: clinical differences in type of transplant and implications for management

2003 • 278 citations

Empirical antifungal therapy in febrile granulocytopenic patients

1989 • 272 citations

Itraconazole Prevents Invasive Fungal Infections in Neutropenic Patients Treated for Hematologic Malignancies: Evidence From a Meta-Analysis of 3,597 Patients

2003 • 264 citations

Pharmacology of Itraconazole

2001 • 263 citations

An EORTC International Multicenter Randomized Trial (EORTC Number 19923) Comparing Two Dosages of Liposomal Amphotericin B for Treatment of Invasive Aspergillosis

1998 • 259 citations

Aspergillosis of the central nervous system: Clinicopathological analysis of 17 patients

1985 • 258 citations

Aspergillus nidulans Infection in Chronic Granulomatous Disease

1998 • 258 citations

Ulcerative Tracheobronchitis after Lung Transplantation: A New Form of Invasive Aspergillosis

1991 • 258 citations

Antifungal prophylaxis for severely neutropenic chemotherapy recipients

2002 • 258 citations

In Vitro Amphotericin B Resistance in Clinical Isolates of Aspergillus terreus , with a Head-to-Head Comparison to Voriconazole

1999 • 254 citations

Experimental Pulmonary Aspergillosis Due toAspergillus terreus:Pathogenesis and Treatment of an Emerging Fungal Pathogen Resistant to Amphotericin B

2003 • 248 citations

Use of Real‐Time PCR on Blood Samples for Diagnosis of Invasive Aspergillosis

2001 • 248 citations

False‐Positive Galactomannan PlateliaAspergillusTest Results for Patients Receiving Piperacillin‐Tazobactam

2004 • 247 citations

Activity of posaconazole in the treatment of central nervous system fungal infections

2005 • 244 citations

Safety, Tolerability, and Pharmacokinetics of Micafungin (FK463) in Febrile Neutropenic Pediatric Patients

2005 • 242 citations

Pharmacokinetics, Safety, and Tolerability of Caspofungin in Children and Adolescents

2005 • 240 citations

Advances and challenges in management of invasive mycoses

2005 • 233 citations

Combination Therapy in Treatment of Experimental Pulmonary Aspergillosis: Synergistic Interaction between an Antifungal Triazole and an Echinocandin

2003 • 233 citations

Multicenter clinical evaluation of the (1→3)β-D-glucan assay as an aid to diagnosis of fungal infections in humans: Ostrosky-Zeichner L, Alexander BD, Kett DH, et al: Clin Infect Dis 41 (5) : 654-659, 2005

2006 • 230 citations

Correlation between in-vitro susceptibility testing to itraconazole and in-vivo outcome of Aspergillus fumigatus infection

1997 • 227 citations

Refractory Aspergillus pneumonia in patients with acute leukemia

2003 • 227 citations

The invasive and saprophytic syndromes due toAspergillusspp.

2005 • 220 citations

Invasive fungal infections after allogeneic peripheral blood stem cell transplantation: incidence and risk factors in 395 patients

2002 • 218 citations

Galactomannan detection in computerized tomography‐based broncho‐alveolar lavage fluid and serum in haematological patients at risk for invasive pulmonary aspergillosis

2003 • 215 citations

Itraconazole oral solution and intravenous formulations: a review of pharmacokinetics and pharmacodynamics

2001 • 214 citations

Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis

2006 • 212 citations

Plasma (1--&gt;3)-beta-D-glucan and fungal antigenemia in patients with candidemia, aspergillosis, and cryptococcosis

1995 • 210 citations

The Evolution and Evaluation of a Whole Blood Polymerase Chain Reaction Assay for the Detection of Invasive Aspergillosis in Hematology Patients in a Routine Clinical Setting

2006 • 210 citations

A randomized controlled trial of itraconazole versus fluconazole for the prevention of fungal infections in patients with haematological malignancies

1999 • 205 citations

Multi-azole resistance in Aspergillus fumigatus

2006 • 202 citations

Monitoring plasma voriconazole levels may be necessary to avoid subtherapeutic levels in hematopoietic stem cell transplant recipients

2007 • 200 citations

Early Detection ofAspergillusInfection after Allogeneic Stem Cell Transplantation by Polymerase Chain Reaction Screening

2000 • 200 citations

Aspergillosis: Spectrum of Disease, Diagnosis, and Treatment

2006 • 197 citations

Prospective Assessment of Platelia™Aspergillus Galactomannan Antigen for the Diagnosis of Invasive Aspergillosis in Lung Transplant Recipients

2004 • 196 citations

Itraconazole therapy in aspergillosis: Study in 49 patients

1990 • 196 citations

Combination and Sequential Antifungal Therapy for Invasive Aspergillosis: Review of Published In Vitro and In Vivo Interactions and 6281 Clinical Cases from 1966 to 2001

2003 • 195 citations

Late onset of invasive aspergillus infection in bone marrow transplant patients at a university hospital

2002 • 193 citations

Treatment with Piperacillin‐Tazobactam and False‐PositiveAspergillusGalactomannan Antigen Test Results for Patients with Hematological Malignancies

2004 • 191 citations

Aspergilloma: a series of 89 surgical cases

2000 • 190 citations

Comparison of an enzyme immunoassay and latex agglutination test for detection of galactomannan in the diagnosis of invasive aspergillosis

1996 • 190 citations

Stevens et al. (2003; 37[Suppl 3]:S225–64)

2003 • 190 citations

Impact of Previous Aspergillosis on the Outcome of Bone Marrow Transplantation

1998 • 188 citations

Efficacy of Unilamellar Liposomal Amphotericin B in Treatment of Pulmonary Aspergillosis in Persistently Granulocytopenic Rabbits: The Potential Role of Bronchoalveolar D-Mannitol and Serum Galactomannan as Markers of Infection

1994 • 187 citations

Real-Time PCR Coupled with Automated DNA Extraction and Detection of Galactomannan Antigen in Serum by Enzyme-Linked Immunosorbent Assay for Diagnosis of Invasive Aspergillosis

2002 • 185 citations

Cyclophosphamide metabolism is affected by azole antifungals

2003 • 184 citations

Allergic aspergillus sinusitis: Concepts in diagnosis and treatment of a new clinical entity

1987 • 179 citations

Antifungal Activity and Pharmacokinetics of Posaconazole (SCH 56592) in Treatment and Prevention of Experimental Invasive Pulmonary Aspergillosis: Correlation with Galactomannan Antigenemia

2001 • 179 citations

LIPOSOMAL AMPHOTERICIN B PREVENTS INVASIVE FUNGAL INFECTIONS IN LIVER TRANSPLANT RECIPIENTS

1995 • 178 citations

Optimization of the Cutoff Value for the Aspergillus Double-Sandwich Enzyme Immunoassay

2007 • 177 citations

Invasive Aspergillosis in Allogeneic Stem Cell Transplant Recipients: Increasing Antigenemia Is Associated with Progressive Disease

2002 • 177 citations

Aspergillosis of the brain and paranasal sinuses in immunocompromised patients: CT and MR imaging findings.

1994 • 175 citations

Prophylactic Intravenous Amphotericin B in Neutropenic Autologous Bone Marrow Transplant Recipients

1992 • 171 citations

Interferon- and Tumor Necrosis Factor- Protect Mice from Invasive Aspergillosis

1995 • 170 citations

An approach to intensive antileukemia therapy in patients with previous invasive aspergillosis

1988 • 169 citations

Aerosolized Amphotericin B Inhalations as Prophylaxis of Invasive Aspergillus Infections During Prolonged Neutropenia: Results of a Prospective Randomized Multicenter Trial

1999 • 168 citations

Treatment of Chronic Pulmonary Aspergillosis by Voriconazole in Nonimmunocompromised Patients

2007 • 168 citations

Prevention and Early Treatment of Invasive Fungal Infection in Patients with Cancer and Neutropenia and in Stem Cell Transplant Recipients in the Era of Newer Broad-Spectrum Antifungal Agents and Diagnostic Adjuncts

2007 • 166 citations

Intravenous Itraconazole Followed by Oral Itraconazole in the Treatment of Invasive Pulmonary Aspergillosis in Patients with Hematologic Malignancies, Chronic Granulomatous Disease, or AIDS

2001 • 163 citations

Amphotericin B colloidal dispersion vs. amphotericin B as therapy for invasive aspergillosis.

1997 • 163 citations

Epidemiology of invasive aspergillosis in France: a six-year multicentric survey in the Greater Paris area

2002 • 162 citations

Otomycosis: A Clinicomycologic Study

2000 • 159 citations

Aspergillus Meningitis: Diagnosis by Non-Culture-Based Microbiological Methods and Management

1999 • 159 citations

Review of Newer Antifungal and Immunomodulatory Strategies for Invasive Aspergillosis

2003 • 156 citations

113 Bronchoalveolar lavage in allergic bronchopulmonary aspergillosis (ABPA)

1985 • 155 citations

Treatment of neutropenia-related fungal infections with granulocyte colony-stimulating factor-elicited white blood cell transfusions: a pilot study

1997 • 154 citations

Itraconazole Oral Solution for Primary Prophylaxis of Fungal Infections in Patients with Hematological Malignancy and Profound Neutropenia: a Randomized, Double-Blind, Double-Placebo, Multicenter Trial Comparing Itraconazole and Amphotericin B

2000 • 154 citations

Endogenous aspergillus endophthalmitis

1998 • 152 citations

Diagnosis and management of allergic bronchopulmonary aspergillosis.

1986 • 152 citations

Comparative Efficacies of Conventional Amphotericin B, Liposomal Amphotericin B (AmBisome), Caspofungin, Micafungin, and Voriconazole Alone and in Combination against Experimental Murine Central Nervous System Aspergillosis

2005 • 150 citations

SAFETY OF AEROSOLIZED AMPHOTERICIN B LIPID COMPLEX IN LUNG TRANSPLANT RECIPIENTS12

2001 • 150 citations

In vitro susceptibility and synergy studies of Aspergillus species to conventional and new agents

1992 • 149 citations

Aspergillus species endocarditis

1974 • 148 citations

Chronic forms of pulmonary aspergillosis

2001 • 146 citations

Infections diagnosed in the first year after pediatric stem cell transplantation

2002 • 146 citations

Reactivity of (1→3)-β- <scp>d</scp> -Glucan Assay with Commonly Used Intravenous Antimicrobials

2006 • 144 citations

Efficacy of Galactomannan Antigen in the Platelia Aspergillus Enzyme Immunoassay for Diagnosis of Invasive Aspergillosis in Liver Transplant Recipients

2004 • 144 citations

Aspergillus Galactomannan Antigen in the Cerebrospinal Fluid of Bone Marrow Transplant Recipients with Probable Cerebral Aspergillosis

2002 • 142 citations

Fungal Keratitis: Emerging Trends and Treatment Outcomes

2006 • 141 citations

Management of Invasive Pulmonary Aspergillosis in Hematology Patients: A Review of 87 Consecutive Cases at a Single Institution

2000 • 141 citations

Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation

1991 • 138 citations

Differences in beta-glucan levels in culture supernatants of a variety of fungi

2006 • 137 citations

Muco-cutaneous retinoid-effects and facial erythema related to the novel triazole antifungal agent voriconazole

2001 • 135 citations

Liposomal Amphotericin B (AmBisome) Therapy in Invasive Fungal Infections

1995 • 134 citations

Evaluation of agent and host factors in progression of mycotic keratitis

2002 • 134 citations

Primary Invasive Aspergillosis of the Digestive Tract: Report of Two Cases and Review of the Literature

2006 • 130 citations

Nebulized amphotericin B prophylaxis for Aspergillus infection in lung transplantation: study of risk factors

2001 • 129 citations

Impact of the intensity of the pretransplantation conditioning regimen in patients with prior invasive aspergillosis undergoing allogeneic hematopoietic stem cell transplantation: a retrospective survey of the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation

2006 • 129 citations

Ulcerative and Plaque-Like Tracheobronchitis Due to Infection with Aspergillus in Patients with AIDS

1993 • 128 citations

Prospective clinical evaluation of a LightCyclerTM‐mediated polymerase chain reaction assay, a nested‐PCR assay and a galactomannan enzyme‐linked immunosorbent assay for detection of invasive aspergillosis in neutropenic cancer patients and haematological stem cell transplant recipients

2004 • 127 citations

Bronchial Artery Embolization for Hemoptysis Due to Benign Diseases: Immediate and Long-Term Results

2000 • 127 citations

Fluconazole versus itraconazole for antifungal prophylaxis in neutropenic patients with haematological malignancies: a meta-analysis of randomised-controlled trials

2005 • 126 citations

Mycotic infection of the ear (otomycosis): A prospective study

1989 • 125 citations

Role of early diagnosis and aggressive surgery in the management of invasive pulmonary aspergillosis in neutropenic patients

2001 • 124 citations

Voriconazole for Invasive Bone Aspergillosis: A Worldwide Experience of 20 Cases

2005 • 123 citations

Safety, Pharmacokinetics, and Pharmacodynamics of Cyclodextrin Itraconazole in Pediatric Patients with Oropharyngeal Candidiasis

2002 • 121 citations

Voriconazole Concentration in Human Aqueous Humor and Plasma during Topical or Combined Topical and Systemic Administration for Fungal Keratitis

2006 • 120 citations

Bifidobacterium lipoteichoic acid and false ELISA reactivity in aspergillus antigen detection

2004 • 120 citations

Aspergillus osteomyelitis

1982 • 119 citations

A Double-Blind, Randomized, Placebo-Controlled Trial of Itraconazole Capsules as Antifungal Prophylaxis for Neutropenic Patients

2000 • 118 citations

Analysis of compassionate use itraconazole therapy for invasive aspergillosis by the NIAID Mycoses Study Group criteria.

1997 • 117 citations

Determination of plasma (1 → 3)-β-<scp>d</scp>-glucan: A new diagnostic aid to deep mycosis

1992 • 117 citations

Topical and Oral Voriconazole in the Treatment of Fungal Keratitis

2006 • 116 citations

Voriconazole Treatment for Subacute Invasive and Chronic Pulmonary Aspergillosis

2006 • 114 citations

Prdictive Value Of Inducible Endothelial Cell Adhesion Molecule Expression For Acte Rejection Of Human Cardiac Allografts

1995 • 111 citations

CT of invasive pulmonary aspergillosis

1988 • 111 citations

Allergic fungal rhinosinusitis

2000 • 106 citations

Invasive Aspergillosis in the Setting of Cardiac Transplantation

2003 • 105 citations

Comparison of Non-Culture-Based Methods for Detection of Systemic Fungal Infections, with an Emphasis on Invasive Candida Infections

2005 • 105 citations

Diagnosing Invasive Aspergillosis during Antifungal Therapy by PCR Analysis of Blood Samples

2004 • 105 citations

Cutaneous Fungal Infections in the Oncology Patient

2006 • 105 citations

Fungal infections of the central nervous system

1985 • 103 citations

Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis

2007 • 103 citations

Aspergillus terreus infections in haematological malignancies: molecular epidemiology suggests association with in-hospital plants

2000 • 100 citations

Invasive Pulmonary Aspergillosis Soon After Therapy With Infliximab, a Tumor Necrosis Factor-Alpha–Neutralizing Antibody: A Possible Healthcare-Associated Case?

2003 • 98 citations

Randomized controlled trial of oral itraconazole solution versus intravenous/oral fluconazole for prevention of fungal infections in liver transplant recipients1

2002 • 98 citations

Comparison of Topical Itraconazole 1% With Topical Natamycin 5% for the Treatment of Filamentous Fungal Keratitis

2005 • 95 citations

Variability of Voriconazole Plasma Levels Measured by New High-Performance Liquid Chromatography and Bioassay Methods

2006 • 95 citations

Surgical Management of Invasive Pulmonary Aspergillosis in Neutropenic Patients

1997 • 94 citations

Spinal Aspergillus Osteomyelitis

1999 • 93 citations

Invasive Central Nervous System Aspergillosis

1995 • 93 citations

Treatment of Experimental Invasive Aspergillosis with Novel Amphotericin B/Cholesterol-Sulfate Complexes

1989 • 92 citations

Itraconazole Preexposure Attenuates the Efficacy of Subsequent Amphotericin B Therapy in a Murine Model of Acute Invasive Pulmonary Aspergillosis

2002 • 89 citations

Fatal haemoptysis in pulmonary filamentous mycosis: an underevaluated cause of death in patients with acute leukaemia in haematological complete remission. A retrospective study and review of the literature

1995 • 88 citations

Aspergillus fumigatus Keratitis After Laser In Situ Keratomileusis

2001 • 88 citations

Clinical Issues Regarding Relapsing Aspergillosis and the Efficacy of Secondary Antifungal Prophylaxis in Patients with Hematological Malignancies

2006 • 87 citations

Reactivity of Platelia Aspergillus Galactomannan Antigen with Piperacillin-Tazobactam: Clinical Implications Based on Achievable Concentrations in Serum

2004 • 87 citations

Neonatal Primary Cutaneous Aspergillosis: Case Report and Review of the Literature

2002 • 86 citations

Non–Culture-Based Diagnostics for Opportunistic Fungi

2006 • 86 citations

Invasive sinus aspergillosis in apparently immunocompetent hosts

1998 • 86 citations

Management of Aspergillus Osteomyelitis: Report of Failure of Liposomal Amphotericin B and Response to Voriconazole in an Immunocompetent Host and Literature Review

2003 • 86 citations

The efficacy and tolerability of voriconazole in the treatment of chronic cavitary pulmonary aspergillosis

2006 • 84 citations

Invasive aspergillosis in neutropenic patients: rapid neutrophil recovery is a risk factor for severe pulmonary complications

1999 • 82 citations

Chronic invasive aspergillosis of the paranasal sinuses in immunocompetent hosts from Saudi Arabia.

2001 • 81 citations

Aspergillus pericarditis: Clinical and pathologic features in the immunocompromised patient

1982 • 78 citations

Chronic Necrotizing Pulmonary Aspergillosis: Pathologic Outcome After Itraconazole Therapy

1996 • 77 citations

INTRAVITREAL VORICONAZOLE FOR DRUG-RESISTANT FUNGAL ENDOPHTHALMITIS

2006 • 77 citations

Analysis of Compassionate Use Itraconazole Therapy for Invasive Aspergillosis by the NIAID Mycoses Study Group Criteria

1997 • 75 citations

Anastomotic infections in lung transplant recipients.

2000 • 74 citations

The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of invasive aspergillosis1

2003 • 74 citations

Pulmonary host defences against Aspergillus fumigatus

1998 • 74 citations

Intracameral Amphotericin B

2001 • 73 citations

Allergic Aspergillus sinusitis

1985 • 73 citations

Aspergillus Valve Endocarditis in Patients without Prior Cardiac Surgery

2000 • 72 citations

Prolonged evaluation of patients with corticosteroid-dependent asthma stage of allergic bronchopulmonary aspergillosis

1987 • 72 citations

Effect of Immunosuppression and Amphotericin B on Aspergillus Antigenemia in an Experimental Model

1988 • 71 citations

Treatment of invasive aspergillus sinusitis with liposomal‐amphotericin B

1987 • 70 citations

Quandary about treatment of aspergillomas persists

1996 • 70 citations

Antigen detection in the diagnosis and management of a patient with probable cerebral aspergillosis treated with voriconazole

2000 • 69 citations

An algorithmic approach to aspergillus sinusitis

1994 • 69 citations

Aspergillus fumigatus Empyema, Arthritis, and Calcaneal Osteomyelitis in a Lung Transplant Patient Successfully Treated with Posaconazole

2004 • 67 citations

Aspergillus Mural Endocarditis

1979 • 67 citations

Detection of Antigen in Sera of Patients with Invasive Aspergillosis: Intra- and Interlaboratory Reproducibility

1998 • 65 citations

Successful bone marrow transplantation in patients with previous invasive fungal infections: report of four cases.

1994 • 64 citations

Efficacy of SCH56592 in a Rabbit Model of Invasive Aspergillosis

2000 • 62 citations

Aerosol Deposition of Lipid Complex Amphotericin-B (Abelcet) in Lung Transplant Recipients

2006 • 62 citations

Treatment of Cerebral Aspergillosis with Itraconazole: Do High Doses Improve the Prognosis?

1995 • 62 citations

New antifungal agents under development in children and neonates

2005 • 59 citations

Report of Successful Prolonged Antifungal Therapy for Refractory Allergic Fungal Sinusitis

2000 • 59 citations

Non‐comparative evaluation of the safety of aerosolized amphotericin B lipid complex in patients undergoing allogeneic hematopoietic stem cell transplantation

2006 • 58 citations

Usefulness of Inhaled High-dose Corticosteroids in Allergic Bronchopulmonary Aspergillosis

1993 • 57 citations

Diagnosis and Management of Allergic Bronchopulmonary Aspergillosis

1994 • 56 citations

Oral Itraconazole Therapy for Mycotic Keratitis/Orale Itraconazol‐Therapie bei mykotischer Keratitis

1988 • 54 citations

Fungal peritonitis in 15 patients on continuous ambulatory peritoneal dialysis (CAPD)

2003 • 54 citations

Evidence-based review of antifungal prophylaxis in neutropenic patients with haematological malignancies

2005 • 53 citations

Intravenous Itraconazole

2001 • 52 citations

Clinical evaluation and reproducibility of the Pastorex Aspergillus antigen latex agglutination test for diagnosing invasive aspergillosis.

1995 • 52 citations

Use of Voriconazole in the Treatment of Fungal Keratitis

2007 • 52 citations

Aspergillus endocarditis and myocarditis in a patient with the acquired immunodeficiency syndrome (AIDS)

1990 • 52 citations

Overview: non-fumigatus species of Aspergillus: perspectives on emerging pathogens in immunocompromised hosts.

2001 • 51 citations

The treatment of pulmonary aspergilloma.

2001 • 51 citations

Diagnosis of Atypical Cases of Infectious Mononucleosis

2001 • 50 citations

Safety and Efficacy of Amphotericin B Colloidal Dispersion

1999 • 50 citations

Issues with galactomannan testing

2006 • 50 citations

Oral itraconazole plus nasal amphotericin B for prophylaxis of invasive aspergillosis in patients with hematological malignancies

1993 • 49 citations

Itraconazole treatment of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

2002 • 48 citations

Evaluation of Serum Sandwich Enzyme-Linked Immunosorbent Assay for Circulating Galactomannan during Caspofungin Therapy: Results from the Caspofungin Invasive Aspergillosis Study

2005 • 48 citations

An Outbreak of Cutaneous Aspergillosis in a Tertiary-Care Hospital

1996 • 46 citations

Aspergillus endocarditis after open heart surgery: an epidemiological investigation

1990 • 45 citations

Peritonitis due to Aspergillus and zygomycetes in patients undergoing peritoneal dialysis: report of 2 cases and review of the literature

2003 • 44 citations

Fungal osteoarticular infections in patients treated at a comprehensive cancer centre: a 10-year retrospective review

2006 • 43 citations

Mycoses in Pediatric Patients

2006 • 41 citations

Th1/Th2 in aspergillosis

2006 • 41 citations

Successful Treatment of Aspergillus Prosthetic Valve Endocarditis with Oral Voriconazole

2005 • 41 citations

Aspergillus flavusmycetoma and epidural abscess successfully treated with itraconazole

1996 • 41 citations

Intravenous Itraconazole followed by Oral Itraconazole for the Treatment of Amphotericin-B-Refractory Invasive Pulmonary Aspergillosis

2003 • 40 citations

Spinal aspergillus vertebral osteomyelitis with extradural abscess: case report and review of literature

2004 • 39 citations

Recommendations for managing Aspergillus osteomyelitis and joint infections based on a review of the literature

2005 • 39 citations

Aspergillus osteomyelitis after liver transplantation

2000 • 36 citations

Refractory pulmonary aspergillosis: compassionate trial with terbinafine

1996 • 36 citations

Fungal endophthalmitis caused byAspergillus ustusin a patient following cataract surgery

2006 • 35 citations

Aspergillus Infection of Prosthetic Aortic Valves

1971 • 34 citations

Full thoracoscopic approach for surgical management of invasive pulmonary aspergillosis

2002 • 34 citations

Transmission of Vaccinia Virus and Rationale for Measures for Prevention

2003 • 33 citations

Aspergillus tracheobronchitis after allogeneic bone marrow transplantation

1999 • 33 citations

MEDICAL MANAGEMENT OFASPERGILLUS FLAVUSENDOCARDITIS

2000 • 32 citations

Surgical management of pulmonary infections in chronic granulomatous disease of childhood

1993 • 32 citations

Clinical evaluation of Aspergillus‐PCR for detection of invasive aspergillosis in immunosuppressed patients

2005 • 31 citations

The concentration-dependent nature of in vitro amphotericin B–itraconazole interaction against Aspergillus fumigatus: isobolographic and response surface analysis of complex pharmacodynamic interactions

2006 • 31 citations

Nasosinus aspergillosis in Sudanese patients: clinical features, pathology, diagnosis, and treatment.

1999 • 31 citations

Deep sinus aspergillosis in a liver transplant recipient successfully treated with a combination of caspofungin and voriconazole

2004 • 30 citations

Detection of (1–3)‐β‐<scp>D</scp>‐glucan in a rat model of aspergillosis

1995 • 30 citations

Disseminated aspergillosis presenting with endophthalmitis: A case report and a review of the literature

1984 • 30 citations

Fatal primary cutaneous aspergillosis in a bone marrow transplant recipient: nosocomial acquisition in a laminar-air flow room

1997 • 29 citations

Early Onset Endophthalmitis Caused by Aspergillus Species Following Cataract Surgery

2006 • 29 citations

Endocarditis Caused byAspergillusSpecies in Injection Drug Users

2001 • 29 citations

Aspergillus fumigatus tricuspid native valve endocarditis in a non-intravenous drug user

2006 • 29 citations

Resolution of invasive central nervous system aspergillosis in a transplant recipient

1997 • 29 citations

Invasive Aspergillus sinusitis During Bone Marrow Transplantation

1997 • 28 citations

Topical amphotericin B application in severe bronchial aspergillosis after lung transplantation: report of experiences in 3 cases

2000 • 27 citations

Successful Treatment of Cerebral Aspergillosis with a High Oral Dose of Itraconazole after Excisional Surgery.

1999 • 27 citations

Chemoprophylaxis for pulmonary aspergillosis during intensive chemotherapy.

1994 • 25 citations

An Outbreak of Cutaneous Aspergillosis in a Tertiary-Care Hospital

1996 • 25 citations

SUCCESSFUL TREATMENT OF ASPERGILLUS BRAIN ABSCESS IN A CHILD WITH ACUTE LYMPHOBLASTIC LEUKEMIA

2000 • 25 citations

Amphotericin B prophylaxis against invasive fungal infections in neutropenic patients: A single center experience from 1980 to 1995

1996 • 24 citations

Isolated Renoureteric Aspergilloma Due to Aspergillus flavus: Case Report and Review of the Literature

2001 • 24 citations

Critique of trials in allergic bronchopulmonary aspergillosis and fungal allergy

2006 • 23 citations

Successful treatment of invasive aspergillosis complicating prolonged treatment‐related neutropenia in acute myelogenous leukemia with amphotericin B lipid complex

1995 • 21 citations

Aspergillus cholangitis: A late complication after Kasai portoenterostomy

2002 • 20 citations

Renal Aspergilloma Due to Aspergillus flavus

1995 • 19 citations

Successful treatment of post-mitral valve annuloplasty aspergillus flavus endocarditis

1985 • 18 citations

Safety of Caspofungin for Treating Invasive Nasal Sinus Aspergillosis in a Kidney Transplant Recipient

2005 • 17 citations

Spinal epidural abscess due to infection of the vertebrae: Report of 3 cases

1996 • 16 citations

Calcium oxalate crystal deposition in necrotizing otomycosis caused by Aspergillus niger.

1993 • 16 citations

Granulocyte transfusion therapy 2006: The comeback kid?

2006 • 14 citations

Allergic fungal rhinosinusitis: report of 4 cases from Saudi Arabia.

2000 • 11 citations

Isolated Kidney Localization of Invasive Aspergillosis in a Patient with AIDS

1994 • 11 citations

Percutaneous Intracavitary Antifungals for a Patient with Pulmonary Aspergilloma; with a Special Reference to in vivo Efficacies and in vitro Susceptibility Results.

1995 • 10 citations

Liposomal amphotericin B as antifungal prophylaxis in bone marrow transplant patients

2006 • 9 citations

Recovery of non-invasive Aspergillus sinusitis by endoscopic sinus surgery.

1997 • 9 citations

Primary bilateral parenchymal renal aspergillus infection

2002 • 9 citations

Know the whole history.

2005 • 7 citations

Aspergillus endophthalmitis: a clinical and experimental study.

1992 • 7 citations

The role of surgery and itraconazole in Aspergillus peritonitis in CAPD

1996 • 6 citations

Update on chronic granulomatous disease: the concept of the near-normal host.

2000 • 4 citations

Successful treatment of chronic necrotizing pulmonary aspergillosis with intracavitary instillation of amphotericin B--a case report.

1995 • 4 citations

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Treatment of Aspergillosis: Clinical Practice Guidelines of the Infectious Diseases… (2008) – Clinical Infectious Diseases | Metascience Observatory Explorer