Aging and Motor Learning: A Possible Role for Norepinephrine in Cerebellar Plasticity

A theory of cerebellar cortex

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Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.

1990 • 1,142 citations

Purkinje cell activity during motor learning

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A theory of memory that explains the function and structure of the cerebellum

1974 • 233 citations

Interaction of norepinephrine with cerebellar activity evoked by mossy and climbing fibers

1977 • 225 citations

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1988 • 193 citations

How the cerebellum could memorise movements

1975 • 165 citations

The cerebellum and learning processes in animals

1990 • 143 citations

Senescent changes in a neurobiological model system: Cerebellar Purkinje cell electrophysiology and correlative anatomy

1980 • 115 citations

Properties of adenylate cyclase from senescent rat brain

1973 • 112 citations

A QUANTITATIVE MICROIONTOPHORETIC ANALYSIS OF THE RESPONSES OF CENTRAL NEURONES TO NORADRENALINE: INTERACTIONS WITH COBALT, MANGANESE, VERAPAMIL AND DICHLOROISOPRENALINE

1975 • 105 citations

Cerebellar norepinephrine depletion and impaired acquisition of specific locomotor tasks in rats

1984 • 100 citations

The neural basis for motor learning in the vestibulo-ocular reflex in monkeys

1988 • 100 citations

Loss of Synapses in the Cerebellar Cortex of the Senescent Rat

1979 • 94 citations

Ability of aged rats to alter beta adrenergic receptors of brain in response to repeated administration of reserpine and desmethylimipramine.

1979 • 94 citations

Senescent pathology of cerebellum: Purkinje neurons and their parallel fiber afferents

1981 • 87 citations

Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats

1992 • 87 citations

NORADRENALINE MODULATION OF THE RESPONSES OF THE CEREBELLAR PURKINJE CELL TO AFFERENT SYNAPTIC ACTIVITY

1976 • 81 citations

Ibogaine fails to reduce naloxone-precipitated withdrawal in the morphine-dependent rat

1990 • 78 citations

Purkinje cell number related to rate of classical conditioning

1990 • 66 citations

Quantitative analysis of dendritic networks of Purkinje neurons during aging

1986 • 63 citations

Beta-1 adrenergic receptors mediate noradrenergic facilitation of purkinje cell responses to gamma-aminobutyric acid in cerebellum of rat

1983 • 60 citations

Injections of β-noradrenergic substances in the flocculus of rabbits affect adaptation of the VOR gain

1990 • 50 citations

Neurobiological Substrates of Classical Conditioning across the Life Span

1990 • 44 citations

Interaction of norepinephrine with purkinje cell responses to cerebellar afferent inputs in aged rats

1985 • 44 citations

Age-related reduction in responses of rat hippocampal neurons to locally applied monoamines

1988 • 41 citations

6-OHDA induced effects upon the acquisition and performance of specific locomotor tasks in rats

1983 • 37 citations

Altered sensitivity of forebrain neurones to iontophoretically applied noradrenaline in aging rats

1983 • 36 citations

Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity

1988 • 34 citations

Age-related subsensitivity of cerebellar Purkinje neurons to locally applied beta1-selective adrenergic agonist

1990 • 29 citations

Age-related alterations in noradrenergic neurotransmission in Sprague-Dawley and Fischer 344 rat strains

1983 • 28 citations

Quantitative autoradiographic analysis of 125I-pindolol binding in Fischer 344 rat brain: Changes in β-adrenergic receptor density with aging

1988 • 28 citations

Vestibulo-ocular reflex adaptation in cats before and after depletion of norepinephrine

1988 • 27 citations

Diminished interaction of norepinephrine with climbing fiber inputs to cerebellar Purkinje neurons in aged Fischer 344 rats

1986 • 23 citations

Age-related electrophysiological changes in cerebellar noradrenergic receptors

1988 • 17 citations