The sick euthyroid syndrome: changes in thyroid hormone serum parameters and hormone metabolism

Shock and Tissue Injury Induced by Recombinant Human Cachectin

1986 • 2,587 citations

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

Alterations in Thyroid Function in Patients with Systemic Illness: The “Euthyroid Sick Syndrome”*

1982 • 927 citations

Interleukin‐6 is the major regulator of acute phase protein synthesis in adult human hepatocytes

1989 • 856 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

RAISED SERUM LEVELS OF TUMOUR NECROSIS FACTOR IN PARASITIC INFECTIONS

1986 • 469 citations

Thyroid hormone metabolism

1986 • 451 citations

EVIDENCE FOR TUMOUR NECROSIS FACTOR/CACHECTIN PRODUCTION IN CANCER

1987 • 425 citations

Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.

1985 • 423 citations

Free thyroxine in human serum: simplified measurement with the aid of magnesium precipitation.

1966 • 415 citations

Effects of cytokines on the liver

1991 • 409 citations

High Incidence of Decreased Serum Triiodothyronine Concentration in Patients with Nonthyroidal Disease

1975 • 383 citations

Applications of a New Chemiluminometric Thyrotropin Assay to Subnormal Measurement*

1990 • 371 citations

Thyroxine Therapy in Patients with Severe Nonthyroidal Illnesses and Low Serum Thyroxine Concentration*

1986 • 355 citations

Iodothyronine Metabolism in Rat Liver Homogenates

1978 • 315 citations

Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine, thyroxin, and thyrotropin. A drug influencing peripheral metabolism of thyroid hormones.

1976 • 309 citations

IL-6 modulates the synthesis of a specific set of acute phase plasma proteins in vivo.

1989 • 307 citations

Heterophilic antibodies: a problem for all immunoassays.

1988 • 306 citations

Thyroid Function in Nonthyroidal Illnesses

1983 • 304 citations

The Effect of Glucocorticoid Administration on Human Pituitary Secretion of Thyrotropin and Prolactin

1976 • 303 citations

Hypothyroxinemia in Critically III Patients as a Predictor of High Mortality

1981 • 302 citations

Opposite Effects of Dexamethasone on Serum Concentrations of 3, 3′,5′-Triiodothyronine (Reverse T₃) and 3,3′,5′-Triiodothyronine (T₃)

1975 • 299 citations

An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man.

1976 • 288 citations

Interleukin 6, the third mediator of acute‐phase reaction, modulates hepatic protein synthesis in human and mouse. Comparison with interleukin 1 β and tumor necrosis factor‐α

1988 • 287 citations

Tumor Necrosis Factor: A Putative Mediator of the Sick Euthyroid Syndrome in Man*

1990 • 276 citations

The aging thyroid. Increased prevalence of elevated serum thyrotropin levels in the elderly

1979 • 261 citations

Pathways of Metabolism of Thyroid Hormones

1978 • 242 citations

The Deiodination of the Iodothyronines and of Their Derivatives in Man

1984 • 241 citations

Thyroid Dysfunction in Chronic Renal Failure

1977 • 237 citations

Effect of Tri-Iodothyronine Replacement on the Metabolic and Pituitary Responses to Starvation

1979 • 235 citations

Suppression of Thyrotropin in the Low-Thyroxine State of Severe Nonthyroidal Illness

1985 • 230 citations

Assessment of Thyroid Function by the Combined Use of the Serum Protein-Bound Iodine and Resin Uptake of¹³¹I-Triiodothyronine

1965 • 228 citations

Specificity of sensitive assays of thyrotropin (TSH) used to screen for thyroid disease in hospitalized patients.

1987 • 227 citations

Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis.

1975 • 226 citations

Alterations in Circulating Thyroid Hormones and Thyrotropin in Hepatic Cirrhosis: Evidence for Euthyroidism Despite Subnormal Serum Triiodothyronine

1974 • 223 citations

EFFECT OF SEVERE, CHRONIC ILLNESS ON THYROID FUNCTION

1974 • 215 citations

The Use and Misuse of the Sensitive Thyrotropin Assays

1990 • 208 citations

The Relationship between Serum Triiodothyronine and Thyrotropin during Systemic Illness*

1982 • 203 citations

Hypermetabolic low triiodothyronine syndrome of burn injury

1982 • 202 citations

DOPAMINE INFUSION ACUTELY INHIBITS THE TSH AND PROLACTIN RESPONSE TO TRH

1975 • 200 citations

Misleadingly Low Free Thyroxine Index and Usefulness of Reverse Triiodothyronine Measurement in Nonthyroidal Illnesses

1979 • 196 citations

Changes of Circulating Thyroxine, Triiodothyronine and Reverse Triiodothyronine After Radiographic Contrast Agents

1976 • 193 citations

Relationship between Thyrotropin and Thyroxine Changes during Recovery from Severe Hypothyroxinemia of Critical Illness*

1986 • 189 citations

Propylthiouracil blocks extrathyroidal conversion of thyroxine to triiodothyronine and augments thyrotropin secretion in man.

1975 • 188 citations

Peripheral Serum Thyroxine, Triiodothyronine and Reverse Triiodothyronine Kinetics in the Low Thyroxine State of Acute Nonthyroidal Illnesses

1982 • 187 citations

The Influence of Fasting, Diabetes, and Several Pharmacological Agents on the Pathways of Thyroxine Metabolism in Rat Liver

1978 • 172 citations

RELATIONSHIP OF ALTERED THYROID HORMONE INDICES TO SURVIVAL IN NONTHYROIDAL ILLNESSES

1982 • 171 citations

The Thyroid in End-Stage Renal Disease

1988 • 166 citations

Insulin-like effect of vanadyl ion on streptozotocin-induced diabetic rats

1990 • 165 citations

Circulating Thyroid Hormones and Thyrotropin in Adult Patients with Protein-Calorie Malnutrition

1975 • 165 citations

Impairment of Hypothalamic-Pituitary-Thyroid Function in Rats Treated with Human Recombinant Tumor Necrosis Factor-α (Cachectin)*

1989 • 164 citations

The Aging Thyroid

1979 • 164 citations

SERUM TRIIODOTHYRONINE AND REVERSE TRIIODOTHYRONINE CONCENTRATIONS AFTER SURGICAL OPERATION

1975 • 162 citations

Prevalence of abnormal thyroid function test results in patients with acute medical illnesses

1982 • 160 citations

A sensitive immunoradiometric assay for serum thyroid stimulating hormone: a replacement for the thyrotrophin releasing hormone test?

1984 • 158 citations

Thyroxine Metabolism in the Low Thyroxine State of Critical Nonthyroidal Illnesses*

1981 • 157 citations

A Comparison of Methods for Assessing Thyroid Function in Nonthyroidal Illness *

1982 • 157 citations

The Production and Metabolism of 3,5,3′-Triiodothyronine and 3,3′,5′-Triiodothyronine in Normal and Fasting Subjects*

1978 • 155 citations

Free Thyroxine Estimates in Nonthyroidal Illness: Comparison of Eight Methods *

1981 • 153 citations

Triiodothyronine and Thyroxine in Hyperthyroidism COMPARISON OF THE ACUTE CHANGES DURING THERAPY WITH ANTITHYROID AGENTS

1974 • 150 citations

Prolonged Dopamine Administration and Thyroid Hormone Economy in Normal and Critically 111 Subject*

1980 • 149 citations

Evidence for an Inhibitor of Extrathyroidal Conversion of Thyroxine to 3,5,3'-Triiodothyronine in Sera of Patients with Nonthyroidal Illnesses*

1985 • 149 citations

In Search of an Inhibitor of Thyroid Hormone Binding to Serum Proteins in Nonthyroid Illnesses*

1979 • 147 citations

Determination of Common Parameters of Iodothyronine Metabolism and Distribution in Man by Noncompartmental Analysis

1975 • 138 citations

Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat

1978 • 138 citations

Unique Alterations of Thyroid Hormone Indices in the Acquired Immunodeficiency Syndrome (AIDS)

1989 • 135 citations

Direct determination of free thyroxin in undiluted serum by equilibrium dialysis/radioimmunoassay.

1988 • 133 citations

Pituitary-Thyroid Axis in Critical Illness^*

1987 • 132 citations

Human Recombinant Interleukin-1β Decreases Plasma Thyroid Hormone and Thyroid Stimulating Hormone Levels in Rats*

1988 • 131 citations

Serum Free Thyroxine in Thyroidal and Nonthyroidal Illnesses: A Comparison of Measurements by Radioimmunoassay, Equilibrium Dialysis, and Free Thyroxine Index*

1980 • 130 citations

Evidence for a Factor in the Sera of Patients with Nonthyroidal Disease which Inhibits Iodothyronine Binding by Solid Matrices, Serum Proteins, and Rat Hepatocytes*

1982 • 126 citations

Changes in Circulating Iodothyronines in Euthyroid and Hyperthyroid Subjects Given Ipodate (Oragrafin), an Agent for Oral Cholecystography*

1978 • 126 citations

The Free Hormone Hypothesis Distinction from the Free Hormone Transport Hypothesis

1992 • 124 citations

Metabolic Effects of Tumour Necrosis Factor-α (Cachectin) and Interleukin-1

1989 • 121 citations

Pharmacological interference with in vitro tests of thyroid function

1981 • 121 citations

Deiodination of Thyroid Hormone by Human Liver

1988 • 121 citations

Comprehensive Kinetics of Triiodothyronine Production, Distribution, and Metabolism in Blood and Tissue Pools of the Rat Using Optimized Blood-Sampling Protocols*

1982 • 120 citations

Decreased Nocturnal Surge of Thyrotropin in Nonthyroidal Illness*

1990 • 119 citations

Effects of Tumor Necrosis Factor-α/Cachectin on Thyroid Hormone Metabolism in Mice*

1988 • 118 citations

Characteristics of active transport of thyroid hormone into rat hepatocytes

1981 • 117 citations

Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats.

1984 • 114 citations

EFFECT OF SINGLE DOSE DEXAMETHASONE ON THE CONCENTRATION OF SERUM TRIIODOTHYRONINE IN MAN

1974 • 114 citations

Decreased extrathyroidal triiodothyronine production in nonthyroidal illness: Benefit or harm?

1980 • 114 citations

The effect of T3 and reverse T3 administration on muscle protein catabolism during fasting as measured by 3-methylhistidine excretion

1979 • 111 citations

The Effects of Amiodarone on Serum Thyroid Hormones and Hepatic Thyroxine 5′-Monodeiodination in Rats*

1983 • 110 citations

Mitochondrial and cytosolic ATP/ADP ratios in rat liver in vivo

1981 • 109 citations

Regulation of the Conversion of Thyroxine to Triiodothyronine in the Perfused Rat Liver

1979 • 106 citations

A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia.

1993 • 105 citations

Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids.

1993 • 104 citations

Mechanism of the Heparin-Induced Increase in the Concentration of Free Thyroxine in Plasma*

1987 • 101 citations

Reduced Plasma Thyrotropin Response to Thyrotropin Releasing Hormone After Dexamethasone Administration in Normal Subjects

1973 • 99 citations

The Role of Sulfhydryl Groups on the Impaired Hepatic 3′,3,5-Triiodothyronine Generation from Thyroxine in the Hypothyroid, Starved, Fetal, and Neonatal Rodent

1979 • 98 citations

Observations on the factors that control the generation of triiodothyronine from thyroxine in rat liver and the nature of the defect induced by fasting.

1979 • 98 citations

Decreased transport of thyroxine (T₄), 3,3′‐5‐triiodothyronine (T₃) and 3,3′,5′‐triiodothyronine (rT₃) into rat hepatocytes in primary culture due to a decrease of cellular ATP content and various drugs

1982 • 97 citations

Relationship between Serum Free Fatty Acids and Thyroid Hormone Binding Inhibitor in Nonthyroid Illnesses*

1985 • 97 citations

Effect of Free Fatty Acids on the Concentration of Free Thyroxine in Human Serum: The Role of Albumin*

1986 • 96 citations

Effect of fasting and acute ethanol administration on the energy state of in vivo liver as measured by 31P-NMR spectroscopy

1986 • 95 citations

LIMITATIONS OF A NEW FREE THYROXINE ASSAY (AMERLEX® FREE T4)

1981 • 94 citations

Estimation of Rapidly Exchangeable Cellular Thyroxine from the Plasma Disappearance Curves of Simultaneously Administered Thyroxine-131I and Albumin-125I*

1967 • 91 citations

Clinical Utility and Cost-Effectiveness of Sensitive Thyrotropin Assays in Ambulatory and Hospitalized Patients

1988 • 90 citations

PLASMA THYROXINE, 3,3′,5-TRIIODOTHYRONINE AND 3,3′,5′-TRIIODOTHYRONINE DURING 3-ADRENERGIC BLOCKADE IN. HYPERTHYROIDISM

1977 • 89 citations

Free Fatty Acids: A Possible Regulator of Free Thyroid Hormone Levels in Man¹

1967 • 88 citations

Sulfation Preceding Deiodination of Iodothyronines in Rat Hepatocytes

1983 • 88 citations

The effects of drugs on tests of thyroid function

1991 • 87 citations

Serum Reverse Triiodothyronine and Thyroxine Kinetics in Patients with Chronic Renal Failure*

1983 • 86 citations

Effects of Prolonged Dopamine Infusion on Anterior Pituitary Function in Normal Males*

1980 • 84 citations

The renal response to respiratory alkalosis.

1952 • 84 citations

Subcellular Alterations Causing Reduced Hepatic Thyroxine-5'-Monodeiodinase Activity in Fasted Rats*

1979 • 84 citations

Measurement of Thyrotropin in Clinical and Subclinical Hyperthyroidism Using a New Chemiluminescent Assay*

1989 • 80 citations

Thyroid test abnormalities in traumatic brain Injury: Correlation with neurologic impairment and sympathetic nervous system activation

1988 • 79 citations

Improved dialysis method for free thyroxin in serum compared with five commercial radioimmunoassays in nonthyroidal illness and subjects with abnormal concentrations of thyroxin-binding globulin.

1983 • 79 citations

Influence of Heparin on Serum Free Thyroxine¹

1969 • 78 citations

Normal Free Thyroxine in Critical Nonthyroidal Illnesses Measured by Ultrafiltration of Undiluted Serum and Equilibrium Dialysis*

1988 • 77 citations

Thyroid Disease and High Concentration of Serum Thyrotrophin in a Population Sample of Women

1981 • 74 citations

Kinetic Studies of Thyroxine, 3,5,3′-Triiodothyronine, 3,3′,5′-Triiodothyronine, 3′,5′-Diiodothyronine, 3,3′-Diiodothyronine, and 3′-Monoiodothyronine in Patients with Liver Cirrhosis*

1981 • 72 citations

Are Selective Increases in Serum Thyroxine (T₄)due to Iodinated Inhibitors of T₄Monodeiodination Indicative of Hyperthyroidism?*

1982 • 72 citations

A Competitive Ligand Binding Assay for Measurement of Thyroid Hormone-Binding Inhibitor in Serum and Tissues*

1984 • 72 citations

DIAGNOSIS OF HYPERTHYROIDISM WHEN SERUM-THYROXINE ALONE IS RAISED

1977 • 69 citations

Drug and Fatty Acid Effects On Serum Thyroid Hormone Binding*

1988 • 69 citations

Alterations in monodeiodination of iodothyronines in the fasting rat: Effects of reduced nonprotein sulfhydryl groups and hypothyroidism

1980 • 68 citations

Protective adaptation of low serum triiodothyronine in patients with chronic renal failure

1985 • 67 citations

Alterations in Serum Thyroid Hormones and Thyroxine-Binding Globulin in Patients with Nephrosis*

1978 • 66 citations

Discrepancies between serum free triiodothyronine and free thyroxin as measured by equilibrium dialysis and analog radioimmunoassay in nonthyroidal illnesses.

1984 • 65 citations

The Effect of Iopanoic Acid on the Regulation of Thyrotropin Secretion in Euthyroid Subjects*

1980 • 64 citations

CARRIER-MEDIATED TRANSPORT OF THYROID HORMONE INTO RAT HEPATOCYTES IS RATE-LIMITING IN TOTAL CELLULAR UPTAKE AND METABOLISM

1986 • 64 citations

Effect of thyroid hormone on metabolic adaptation to fasting

1975 • 64 citations

Fate and biological action of human recombinant interleukin 1β in the rat in vivo

1989 • 64 citations

An Inhibitor of the Binding of Thyroid Hormones to Serum Proteins Is Present in Extrathyroidal Tissues

1982 • 64 citations

Serum thyrotropin in hospitalized psychiatric patients: Evidence for hyperthyrotropinemia as measured by an ultrasensitive thyrotropin assay

1990 • 63 citations

Reduced Triiodothyronine Content in Liver but Not Pituitary of the Uremic Rat Model: Demonstration of Changes Compatible with Thyroid Hormone Deficiency in Liver Only*

1984 • 63 citations

Catabolic effects of thyroid hormone excess: The contribution of adrenergic activity to hypermetabolism and protein breakdown

1987 • 63 citations

Influence of Fasting and Refeeding on 3,3′,5′-Triiodothyronine Metabolism in Man*

1991 • 61 citations

Serum thyroid hormone binding inhibitor in nonthyroidal illnesses

1986 • 60 citations

Accumulation of furancarboxylic acids in uremic serum as inhibitors of drug binding

1988 • 59 citations

Free thyroxine results are affected by albumin concentration and nonthyroidal illness

1983 • 59 citations

Thyroxine Binding Proteins, Free Thyroxine and Thyroxine Turnover Interrelationships during Acute Infectious Illness in Man¹

1972 • 58 citations

Thyroxine Transfer and Distribution in Critical Nonthyroidal Illnesses, Chronic Renal Failure, and Chronic Ethanol Abuse*

1987 • 57 citations

Patients with severe nonthyroidal illness and serum thyrotropin concentrations in the hypothyroid range

1986 • 57 citations

Impaired secretion of TSH in critically ill patients with 'low T4-syndrome'

1982 • 57 citations

A tentative review of recent in vitro observations of the enzymatic deiodination of iodothyronines and its possible physiological implications

1978 • 54 citations

Radioimmunoassay of free thyroxine in serum: comparison with clinical findings and results of conventional thyroid-function tests.

1980 • 53 citations

Effect of Interleukin-1 (IL-1) on Thyroid Hormone Metabolism in Mice: Stimulation by IL-1 of Iodothyronine 5′-Deiodinating Activity (Type I) in the Liver*

1989 • 52 citations

Decreased Serum Triiodothyronine Is Associated with Increased Concentrations of Tumor Necrosis Factor

1990 • 51 citations

Tissue thyroid hormone concentration of rat and man determined by radiommunoassay: biologic significance.

1973 • 47 citations

Isolation and Characterization of an Endogenous Drug-Binding Inhibitor Present in Uremic Serum

1986 • 46 citations

Inhibition by Propranolol of 3,5,3′-Triiodothyronine Formation from Thyroxine in Isolated Rat Renal Tubules: An Effect Independent ofβ-Adrenergic Blockade

1980 • 46 citations

Factitious Elevation of Thyrotropin in a New Ultrasensitive Assay: Implications for the Use of Monoclonal Antibodies in “Sandwich” Immunoassay

1988 • 46 citations

Inhibition of thyroxine transport into cultured rat hepatocytes by serum of nonuremic critically ill patients: effects of bilirubin and nonesterified fatty acids

1993 • 45 citations

Thyroid Hormone Metabolism in Renal Diseases1

2015 • 44 citations

LOW SERUM <scp>l</scp>‐T3 LEVELS IN THE ELDERLY SICK: PROTEIN BINDING, THYROID AND PITUITARY RESPONSIVENESS, AND REVERSE T3 CONCENTRATIONS

1977 • 43 citations

Simultaneous Turnover Studies of Thyroxine, 3,5,3′-and 3,3′,5′-Triiodothyronine, 3,5-, 3,3′-, and 3′,5′-Diiodothyronine, and 3′-Monoiodothyronine in Chronic Renal Failure*

1983 • 43 citations

The distribution kinetics of triiodothyronine: studies of euthyroid subjects with decreased plasma thyroxine-binding globulin and patients with Graves' disease

1970 • 43 citations

Secondary Hypothyroidism in Severe Non Thyroidal Illness?

1981 • 43 citations

Treatment of dopamine-dependent shock with triiodothyronine

1981 • 41 citations

Direct and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. II. Effect of prealbumin, albumin, and thyroxin-binding globulin.

1989 • 41 citations

Pattern of Recovery of Thyroid Hormone Indices Associated with Treatment of Diabetes Mellitus*

1982 • 40 citations

Peripheral Metabolism of Thyroid Hormones in Man, I. Direct Measurement of the Conversion Rate of Thyroxine to 3,5,3'-Triiodothyronine (T₃) and Determination of the Peripheral and Thyroidal Production of T₃

1983 • 40 citations

Transport of 3,5,3'-triiodothyronine into the perfused rat liver and subsequent metabolism are inhibited by fasting.

1992 • 40 citations

Comparison of Methods for Measuring Free Thyroxin in Nonthyroidal Illness

1992 • 39 citations

THE RATIO OF THYROXINE TO THYROXINE‐BINDING GLOBULIN IN THE ASSESSMENT OF THYROID FUNCTION

1979 • 39 citations

Limitations to the Use of a Sensitive Assay for Serum Thyrotropin in the Assessment of Thyroid Status

1989 • 39 citations

Measurement of Thyroxine Uptake from Serum by Cultured Human Hepatocytes as an Index of Thyroid Status: Reduced Thyroxine Uptake from Serum of Patients with Nonthyf oidal Illness*

1985 • 38 citations

A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia

1993 • 38 citations

Thyroid hormone binding in nonthyroid illness

1981 • 38 citations

EFFECTS OF THREE-DAY ORAL CHOLECYSTOGRAPHY ON SERUM IODOTHYRONINES AND TSH CONCENTRATIONS: COMPARISON OF THE EFFECTS AMONG SOME CHOLECYSTOGRAPHIC AGENTS AND THE EFFECTS OF IOPANOIC ACID ON THE PITUITARY-THYROID AXIS

1979 • 38 citations

Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with nonthyroid illness

1991 • 37 citations

On the albumin-dependence of measurements of free thyroxin. II. Patients with non-thyroidal illness.

1987 • 36 citations

Augmentation of protein degradation by l-triiodothyronine in uremia

1989 • 36 citations

Thyroid Function Tests in Patients Undergoing Maintenance Dialysis: Characterization of the &lt;sup&gt;‘&lt;/sup&gt;Low-T&lt;sub&gt;4&lt;/sub&gt; Syndrome’ in Subjects on Regular Hemodialysis and Continuous Ambulatory Peritoneal Dialysis

1987 • 35 citations

Abnormal thyroid function tests in severe non-thyroidal illness: diagnostic and pathophysiologic aspects

1979 • 35 citations

How sensitive are immunometric assays for thyrotropin?

1989 • 34 citations

Serum Angiotensin-Converting Enzyme in Severe Nonthyroidal Illnesses Associated with Low Serum Thyroxine Concentration

1984 • 33 citations

On the albumin dependence of measurements of free thyroxin. I. Technical performance of seven methods.

1986 • 33 citations

Effective laboratory Evaluation of Thyroid Status

1991 • 33 citations

Measurement of serum free thyroxine by RIA in various clinical states.

1980 • 32 citations

Carbohydrate in Contrast to Protein Feeding Increases the Hepatic Content of Active Thyroxine-5′-Deiodinase in the Rat*

1981 • 32 citations

The Influence of Fasting and the Thyroid State on the Activity of Thyroxine 5′-Monodeiodinase in Rat Liver: A Kinetic Analysis of Microsomal Formation of Triiodothyronine from Thyroxine*

1981 • 31 citations

The Role of Thyroxine (T₄)-Binding Serum Proteins in Oleic Acid-Induced Increase in Free T₄in Nonthyroidal Illnesses*

1986 • 31 citations

An improved approach to thyroid function testing in patients with non-thyroidal illness

1986 • 29 citations

Circulating Thyrotrophin as an Index of Thyroid Function

1985 • 29 citations

Slow Thyroxine Binding Globulin in the Pathogenesis of Increased Dialysable Fraction of Thyroxine in Nonthyroidal Illnesses

1983 • 29 citations

Diagnostic value of thyrotropin concentrations in serum as measured by a sensitive immunoradiometric assay.

1986 • 28 citations

“Free Thyroxine Index”: A Reliable Substitute for “Free” Thyroxine Concentration

1974 • 27 citations

Uptake of 3,5,3′-Triiodothyronine by the Perfused Rat Liver: Return to the Free Hormone Hypothesis*

1988 • 26 citations

Changes in rat liver mRNA for alpha-1 acid-glycoprotein, apolipoprotein E, apolipoprotein B and beta-actin after mouse recombinant tumor necrosis factor injection

1989 • 25 citations

Clinical and Laboratory Assessment of Thyroid Abnormalities

1985 • 25 citations

Plasma membrane transport of thyroid hormone: its possible pathophysiological significance

1983 • 24 citations

Fatal nonthyroidal illness may impair nocturnal thyrotropin levels

1990 • 23 citations

STUDIES OF THE RATE OF DISAPPEARANCE OF LABELED THYROXINE FROM THE INTRAVASCULAR COMPARTMENT*

1961 • 23 citations

Interactions between Oleic Acid and Drug Competitors Influence Specific Binding of Thyroxine in Serum*

1991 • 22 citations

ULTRASENSITIVE ASSAY OF THYROID STIMULATING HORMONE IN PATIENTS WITH ACUTE NON‐THYROIDAL ILLNESS

1987 • 20 citations

THE EFFECT OF _D‐ VERSUS _L‐ PROPRANOLOL IN THE TREATMENT OF HYPERTHYROIDISM

1990 • 20 citations

Amiodarone alters thyroxine transfer and distribution in humans

1988 • 20 citations

EFFECT OF HEPARIN ON SERUM FREE THYROXINE LINKED TO POST‐HEPARIN LIPOLYTIC ACTIVITY

1983 • 20 citations

The relation of thyroid indices in the critically ill patient to prognosis and nutritional factors.

1988 • 20 citations

Handling of iodothyronines by the liver and kidney in patients with chronic liver disease

1987 • 20 citations

Effects of immunoscintigraphy with monoclonal antibodies in assays of hormones and tumour markers.

1989 • 18 citations

Free thyroxin by radioimmunoassay: evaluation of a new direct method involving a radiolabeled thyroxin analog.

1983 • 17 citations

EFFECTS OF CHRONIC RENAL DISEASE ON THYROID HORMONE METABOLISM

1977 • 17 citations

Evaluation of free thyroxin measurements in patients with non-thyroidal illnesses.

1981 • 17 citations

The Effect of Surgical Stress on the in Vitro Metabolism of Thyroxine by Rat Liver, Kidney, and Brain*

1991 • 17 citations

Diagnostic value of thyrotropin concentrations in serum as measured by a sensitive immunoradiometric assay.

1986 • 16 citations

Direct and indirect techniques for free thyroxin compared in patients with nonthyroidal illness. III. Analysis of interference variables by stepwise regression

1990 • 16 citations

Transport of 3,5,3'-triiodothyronine into the perfused rat liver and subsequent metabolism are inhibited by fasting

1992 • 16 citations

Development and Use of a Mathematical Two-Pool Model of Distribution and Metabolism of 3,3′,5-Triiodothyronine in a Recirculating Rat Liver Perfusion System: Albumin Does not Play a Role in Cellular Transport*

1990 • 15 citations

Anti-triiodothyronine autoantibodies interfere with two recently commercialized radioimmunoassays for free triiodothyronine.

1984 • 15 citations

Thyroid function in hospitalized patients: effect of illness and serum albumin concentrations.

1987 • 14 citations

Comparison of a new ultrafiltration method for serum free T4 and free T3 with two RIA kits in eight groups of patients

1985 • 14 citations

Evaluation of Five High-Sensitivity American Thyrotropin Assays

1988 • 14 citations

Do nonesterified fatty acids displace thyroxin from its plasma binding sites in severe nonthyroidal illnesses?

1989 • 13 citations

Effects of thyrotropin and thyroid stimulating immunoglobulins on gangliosides labelling of human thyroid cultured pathological cells

1986 • 13 citations

A two-step radioimmunoassay for free triiodothyronine in serum.

1987 • 13 citations

Limitations to the use of a sensitive assay for serum thyrotropin in the assessment of thyroid status

1989 • 12 citations

Concentration of free thyroxin in serum during nonthyroidal illness--calculation or measurement?

1989 • 11 citations

The Charcoal T3 Ratio

1967 • 11 citations

ACCUMULATION AND RELEASE OF THYROID HORMONES BY THE NORMAL AND DISEASED HUMAN LIVER

1969 • 11 citations

Clinical evaluation of free T4 techniques.

1986 • 10 citations

A numerical comparison of the use of T3-uptake values and of tbg levels for the estimation of free thyroxine in serum

1979 • 10 citations

The charcoal T3 ratio. An in vitro test of thyroid function

1967 • 10 citations

Examination of Some Factors Affecting Sensitivity and Reproducibility in Radioimmunoassay of Thyrotropin

1975 • 9 citations

Assessment of an Enhanced Chemiluminescent Immunometric Assay for TSH in 1127 Patients

1987 • 9 citations

Clinical assessment of a radioimmunoassay for free thyroxine using a modified tracer.

1983 • 8 citations

One-step immunoassays for free (unbound) hormones: the effect of tracer binding by serum proteins.

1986 • 8 citations

Good correlation between free thyroid hormone concentrations as measured by equilibrium dialysis and analog radioimmunoassays.

1986 • 7 citations

Thyroid Hormone Binding Inhibition in Critically ill Patients – Who is the Inhibitor?

2009 • 7 citations

Clinical evaluation of two direct procedures for free thyroxin, and of free thyroxin index determined nonisotopically and by measuring thyroxin-binding globulin.

1983 • 7 citations

Diagnostic value of a modified assay of free triiodothyronine in serum.

1987 • 6 citations

Three-compartmental analysis of effects of D-propranolol on thyroid hormone kinetics

1988 • 6 citations

Diagnostic value of a modified assay of free triiodothyronine in serum.

1987 • 6 citations

Abnormal Thyroid Function Tests in Euthyroid Patients

1989 • 5 citations

Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase.

1984 • 5 citations

Binding characteristics of thyroxin binding globulin in serum of normal, pregnant, and severely ill euthyroid patients.

1986 • 5 citations

Binding characteristics of thyroxin binding globulin in serum of normal, pregnant, and severely ill euthyroid patients.

1986 • 5 citations

Enzyme immunoassay of free triiodothyronine in serum.

1987 • 4 citations

Strategy of thyroid-function testing, a comparative study using TT4, FT4I, various FT4 and IRMA-TSH kits.

1986 • 4 citations

Analytical evaluation of twenty assays for determination of thyrotropin (TSH).

1989 • 4 citations

Enzyme immunoassay of free triiodothyronine in serum.

1987 • 4 citations

Estimation of free thyroxin with a new thyroxin analog and a porous-glass solid phase.

1984 • 4 citations

Thyroid Hormone-Binding Inhibitor in Normal, Pregnant, and Lactating Rat and Postmenopausal Human Breast Tissue*

1985 • 3 citations

Analytical and Clinical Evaluation of Three Sensitive Thyrotropin Assays

1989 • 3 citations