Structural Determinants for Branched-chain Aminotransferase Isozyme-specific Inhibition by the Anticonvulsant Drug Gabapentin

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Solvent content of protein crystals

1968 • 7,954 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

An extensively modified version of MolScript that includes greatly enhanced coloring capabilities

1997 • 1,724 citations

[10] Electron-density map interpretation

1997 • 501 citations

The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

2004 • 452 citations

Structure, evolution and action of vitamin B6-dependent enzymes

1998 • 388 citations

[11] Model building and refinement practice

1997 • 328 citations

Transaminase of Branched Chain Amino Acids

1966 • 280 citations

Gabapentin in partial epilepsy

1990 • 205 citations

Nitrogen shuttling between neurons and glial cells during glutamate synthesis

2001 • 187 citations

Role of Branched‐Chain Aminotransferase Isoenzymes and Gabapentin in Neurotransmitter Metabolism

1998 • 159 citations

Crystal Structure of a D-Amino Acid Aminotransferase: How the Protein Controls Stereoselectivity

1995 • 152 citations

Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme.

1993 • 142 citations

Leucine Aminotransferase

1966 • 136 citations

Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues.

1992 • 112 citations

Overexpression and Characterization of the Human Mitochondrial and Cytosolic Branched-chain Aminotransferases

1998 • 105 citations

Role of mitochondrial transamination in branched chain amino acid metabolism.

1988 • 93 citations

Role of specific aminotransferases in de novo glutamate synthesis and redox shuttling in the retina

2001 • 88 citations

Structure and function of branched chain aminotransferases

2001 • 87 citations

Gabapentin monotherapy: I. An 8-day, double-blind, dose controlled, multicenter study in hospitalized patients with refractory complex partial or secondarily generalized seizures

1997 • 87 citations

Branched‐chain amino acids and neurotransmitter metabolism: Expression of cytosolic branched‐chain aminotransferase (BCATc) in the cerebellum and hippocampus

2004 • 83 citations

Crystallographic Study of Steps along the Reaction Pathway of <scp>d</scp>-Amino Acid Aminotransferase^,

1998 • 82 citations

Subcellular Distribution of Branched-Chain Aminotransferase Activity in Rat Tissues

1988 • 81 citations

The tyrosine-225 to phenylalanine mutation of Escherichia coli aspartate aminotransferase results in an alkaline transition in the spectrophotometric and kinetic pKa values and reduced values of both kcat and Km

1991 • 71 citations

Role of Asp222 in the catalytic mechanism of Escherichia coli aspartate aminotransferase: the amino acid residue which enhances the function of the enzyme-bound coenzyme pyridoxal 5'-phosphate

1992 • 70 citations

Crystal Structures of Branched-Chain Amino Acid Aminotransferase Complexed with Glutamate and Glutarate: True Reaction Intermediate and Double Substrate Recognition of the Enzyme^,

2003 • 66 citations

Roles for Cysteine Residues in the Regulatory CXXC Motif of Human Mitochondrial Branched Chain Aminotransferase Enzyme

2004 • 65 citations

Three-Dimensional Structure of Escherichia coli Branched-Chain Amino Acid Aminotransferase at 2.5 Resolution

1997 • 55 citations

Structures of Escherichia coli Branched-Chain Amino Acid Aminotransferase and Its Complexes with 4-Methylvalerate and 2-Methylleucine: Induced Fit and Substrate Recognition of the Enzyme^,

2001 • 48 citations

Three-Dimensional Structure of 4-Amino-4-Deoxychorismate Lyase from Escherichia coli

2000 • 46 citations

Unique stereospecificity of D-amino acid aminotransferase and branched-chain L-amino acid aminotransferase for C-4' hydrogen transfer of the coenzyme

1993 • 44 citations

The structure of human mitochondrial branched-chain aminotransferase

2001 • 44 citations

Identification of a Peroxide-Sensitive Redox Switch at the CXXC Motif in the Human Mitochondrial Branched Chain Aminotransferase

2002 • 41 citations

Crystal Structures of Human Mitochondrial Branched Chain Aminotransferase Reaction Intermediates: Ketimine and Pyridoxamine Phosphate Forms

2002 • 38 citations

Role of an Active Site Residue Analyzed by Combination of Mutagenesis and Coenzyme Analog

1993 • 32 citations

Potential Treatment of Amyotrophic Lateral Sclerosis with Gabapentin: A Hypothesis

1995 • 30 citations

Mammalian Branched-Chain Aminotransferases

2000 • 26 citations

Detection of the Swings of the Lever Arm of a Myosin Motor by Fluorescence Resonance Energy Transfer of Green and Blue Fluorescent Proteins

2000 • 18 citations

Stereochemistry of the Transamination Reaction Catalyzed by Aminodeoxychorismate Lyase from Escherichia coli: Close Relationship between Fold Type and Stereochemistry

2000 • 17 citations

Crystallization and Preliminary X-Ray Characterization of Branched-Chain Amino Acid Aminotransferase from Escherichia coli

1989 • 8 citations

Deleted Work

1955 • 0 citations