Matrix metalloproteinases in arthritic disease.

Matrix Metalloproteinases

1999 • 3,774 citations

MT1-MMP-Deficient Mice Develop Dwarfism, Osteopenia, Arthritis, and Connective Tissue Disease due to Inadequate Collagen Turnover

1999 • 1,280 citations

Matrix metalloproteinases: effectors of development and normal physiology

2000 • 1,236 citations

Activation mechanisms of matrix metalloproteinases.

1997 • 1,134 citations

Proteolytic remodeling of extracellular matrix

1995 • 1,086 citations

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

1997 • 958 citations

Inflammation Dampened by Gelatinase A Cleavage of Monocyte Chemoattractant Protein-3

2000 • 771 citations

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes

2001 • 693 citations

Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1

1997 • 610 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells.

1976 • 555 citations

Matrix Metalloproteinase-8 Is Expressed in Rheumatoid Synovial Fibroblasts and Endothelial Cells

1997 • 493 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis

1999 • 405 citations

Transcriptional Control of Matrix Metalloproteinases and the Tissue Inhibitors of Matrix Metalloproteinases

1997 • 332 citations

Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis

1993 • 325 citations

The role of the C-terminal domain in collagenase and stromelysin specificity.

1992 • 311 citations

Structural basis of the endoproteinase–protein inhibitor interaction

2000 • 283 citations

Binding of gelatinases A and B to type-I collagen and other matrix components

1995 • 270 citations

Detection of Stromelysin and Collagenase in Synovial Fluid From Patients with Rheumatoid Arthritis and Posttraumatic Knee Injury

1992 • 261 citations

Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes

1995 • 242 citations

The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: A kinetic analysis of the inhibition of gelatinase A

1993 • 237 citations

Matrix metalloproteinase 13 (collagenase 3) in human rheumatoid synovium

1997 • 224 citations

Expression of Metalloproteinases and Metalloproteinase Inhibitor in Human Arthritic Synovium

1991 • 217 citations

Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.

1994 • 211 citations

Specific collagenolysis by gelatinase A, MMP‐2, is determined by the hemopexin domain and not the fibronectin‐like domain

2001 • 209 citations

Chondrocyte Matrix Metalloproteinase-8

1996 • 197 citations

Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis.

1995 • 173 citations

Collagenase‐3 (matrix metalloprotease 13) is preferentially localized in the deep layer of human arthritic cartilage in situ. In vitro mimicking effect by transforming growth factor β

1997 • 169 citations

Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain

1993 • 161 citations

Analysis of the role of the COOH-terminal domain in the activation, proteolytic activity, and tissue inhibitor of metalloproteinase interactions of gelatinase B.

1994 • 158 citations

Early response genes induced in chondrocytes stimulated with the inflammatory cytokine interleukin-1beta

2001 • 147 citations

Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

1993 • 145 citations

Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity

1999 • 115 citations

Cloning of the genes for human stromelysin and stromelysin 2: differential expression in rheumatoid synovial fibroblasts

1989 • 109 citations

New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from above

1998 • 103 citations

Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger rna levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis

1993 • 96 citations

Matrix Metalloproteinase Inhibitors in Arthritis

1998 • 95 citations

Comparative immunolocalization studies of collagenase 1 and collagenase 3 production in the rheumatoid lesion, and by human chondrocytes and synoviocytes in vitro

1998 • 89 citations

TNF‐α‐mediated expression of membrane‐type matrix metalloproteinase in rheumatoid synovial fibroblasts

1996 • 89 citations

Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis

2001 • 78 citations

Characterization of the Role of the “MT-loop”

2001 • 75 citations

Inhibition of tumor necrosis factor-alpha (TNF-alpha) production and arthritis in the rat by GW3333, a dual inhibitor of TNF-alpha-converting enzyme and matrix metalloproteinases.

2001 • 74 citations

Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis

1998 • 72 citations

Active Matrix Metalloproteinases Are Present in Cartilage During Immune Complex-Mediated Arthritis: A Pivotal Role for Stromelysin-1 in Cartilage Destruction

1999 • 70 citations

Identification and initial characterization of 5000 expressed sequenced tags (ESTs) each from adult human normal and osteoarthritic cartilage cDNA libraries

2001 • 62 citations

Design and Synthetic Considerations of Matrix Metalloproteinase Inhibitors

1999 • 62 citations

Membrane-Type Matrix Metalloproteinases and Cell Surface-Associated Activation Cascades for Matrix Metalloproteinases

1998 • 61 citations

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes

2001 • 60 citations

Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP‐8) to stability and collagenolytic activity by alanine scanning mutagenesis

1997 • 59 citations

The Clinical Potential of Matrix Metalloproteinase Inhibitors in the Rheumatic Disorders

2001 • 55 citations

Future directions for research and treatment of osteoarthritis

1999 • 54 citations

Engineering of tissue inhibitor of metalloproteinases mutants as potential therapeutics.

2002 • 53 citations

Tyrosine 36 Plays a Critical Role in the Interaction of the AB Loop of Tissue Inhibitor of Metalloproteinases-2 with Matrix Metalloproteinase-14

2001 • 41 citations

Future directions for research and treatment of osteoarthritis

1999 • 32 citations

Collagenase and its Natural Inhibitors in Relation to the Rheumatoid Joint

1977 • 30 citations

Is There a Role for Antibiotics in the Treatment of Patients with Rheumatoid Arthritis?

1999 • 27 citations

The role of exon 5 in fibroblast collagenase (MMP‐1) substrate specificity and inhibitor selectivity

2001 • 20 citations

Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown

1998 • 13 citations

Matrix Metalloproteinases

2000 • 10 citations

Detecting Polymorphisms in MMP Genes

2003 • 5 citations

The role of exon 5 in fibroblast collagenase (MMP-1) substrate specificity and inhibitor selectivity

2001 • 1 citations