Prolonging life and delaying death: The role of physicians in the context of limited intensive care resources

Frailty in Older Adults: Evidence for a Phenotype

2001 • 20,411 citations

To Err Is Human

2000 • 14,385 citations

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

2001 • 9,683 citations

A global clinical measure of fitness and frailty in elderly people

2005 • 6,833 citations

Book Review

2000 • 6,148 citations

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock*

2006 • 5,467 citations

Untangling the Concepts of Disability, Frailty, and Comorbidity: Implications for Improved Targeting and Care

2004 • 3,734 citations

Serial Evaluation of the SOFA Score to Predict Outcome in Critically Ill Patients

2001 • 2,553 citations

Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans

2006 • 1,927 citations

Patterns of Functional Decline at the End of Life

2003 • 1,305 citations

Burnout Syndrome in Critical Care Nursing Staff

2006 • 717 citations

Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock

2002 • 687 citations

Increased cytokine production in mononuclear cells of healthy elderly people

1993 • 648 citations

Breaking bad news: why is it still so difficult?

1984 • 568 citations

Burnout syndrome among critical care healthcare workers

2007 • 541 citations

Quality of life in adult survivors of critical illness: A systematic review of the literature

2005 • 499 citations

Family satisfaction with family conferences about end-of-life care in the intensive care unit: Increased proportion of family speech is associated with increased satisfaction*

2004 • 473 citations

Old or Frail: What Tells Us More?

2004 • 472 citations

Critical Care Nurses’ Perceptions of Futile Care and Its Effect on Burnout

2004 • 462 citations

Withdrawal of Mechanical Ventilation in Anticipation of Death in the Intensive Care Unit

2003 • 417 citations

The Rule of Rescue

2003 • 363 citations

Long-term Neurocognitive Function After Critical Illness

2006 • 343 citations

Outcome, functional autonomy, and quality of life of elderly patients with a long-term intensive care unit stay

2000 • 269 citations

Rationing critical care beds: A systematic review*

2004 • 268 citations

The mortality rate as a function of accumulated deficits in a frailty index

2002 • 255 citations

Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock

2007 • 250 citations

Clinician predictions of intensive care unit mortality*

2004 • 240 citations

Mortality predictions in the intensive care unit: Comparing physicians with scoring systems*

2006 • 235 citations

Surrogate Decision-Makers' Perspectives on Discussing Prognosis in the Face of Uncertainty

2008 • 224 citations

Medical futility: Predicting outcome of intensive care unit patients by nurses and doctors—A prospective comparative study*

2003 • 208 citations

Conflict in the care of patients with prolonged stay in the ICU: types, sources, and predictors

2003 • 199 citations

Dying in the ICU

2003 • 198 citations

Relationship of treatment delays and mortality in patients undergoing fibrinolysis and primary percutaneous coronary intervention. The Global Registry of Acute Coronary Events

2006 • 182 citations

Public healthcare resource allocation and the Rule of Rescue

2008 • 180 citations

Survival of critically ill patients hospitalized in and out of intensive care units under paucity of intensive care unit beds*

2004 • 178 citations

Prediction of survival of critically ill patients by admission comorbidity

1996 • 176 citations

Withholding and Withdrawing Life-Sustaining Therapy

1991 • 144 citations

Futility

2007 • 144 citations

Empathy and Life Support Decisions in Intensive Care Units

2008 • 142 citations

Some mathematical models of frailty and their clinical implications

2002 • 132 citations

Perceptions of "futile care" among caregivers in intensive care units

2007 • 126 citations

Doubt and belief in physicians’ ability to prognosticate during critical illness: The perspective of surrogate decision makers

2008 • 121 citations

Survival of critically ill patients hospitalized in and out of intensive care*

2006 • 112 citations

Factors related to quality of life 12 months after discharge from an intensive care unit

1992 • 112 citations

Changes in quality of life after medical intensive care

2000 • 83 citations

Complexity of Anti‐immunosenescence Strategies in Humans

2006 • 79 citations

Quality of life in adult survivors of critical illness: A systematic review of the literature

2005 • 56 citations

End-of-Life Decision Making in the Seriously Ill Hospitalized Patient: An Organizing Framework and Results of a Preliminary Study

2000 • 51 citations

Meeting Physicians' Responsibilities in Providing End-of-Life Care

2008 • 50 citations

Comparison of outcome predictions made by physicians, by nurses, and by using the Mortality Prediction Model

2001 • 42 citations

Limits on Patient Responsibility

2005 • 36 citations

Combining multiple comorbidities with Acute Physiology Score to predict hospital mortality of critically ill patients: a linked data cohort study

2007 • 35 citations

A protocol‐driven model for the rapid initiation of stroke thrombolysis in the emergency department

2007 • 33 citations

The Virtue of Moral Responsibility and the Obligations of Patients

2005 • 19 citations

Surrogate Decision-Makers' Perspectives on Discussing Prognosis in the Face of Uncertainty

2010 • 5 citations

Tools for predicting risk of mortality in the icu setting do we need a crystal ball or rose colored glasses

2001 • 2 citations

Limits on Patient Responsibility

2006 • 1 citations