Modification of alpha-bungarotoxin and cholinergic ligand-binding properties of Torpedo acetylcholine receptor by a monoclonal anti-acetylcholine receptor antibody.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

An enzymic method for the trace iodination of immunoglobulins and other proteins

1969 • 1,414 citations

The Nicotinic Cholinergic Receptor: Correlation of Molecular Structure with Functional Properties

1982 • 456 citations

Monoclonal antibodies used to probe acetylcholine receptor structure: localization of the main immunogenic region and detection of similarities between subunits.

1980 • 452 citations

A simple assay for the study of solubilized acetylcholine receptors

1973 • 416 citations

Mapping of surface structures of electrophorus acetylcholine receptor using monoclonal antibodies.

1981 • 412 citations

Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides.

1979 • 350 citations

Structure and function of an acetylcholine receptor

1982 • 281 citations

The acetylcholine receptor: an "allosteric" membrane protein.

1979 • 256 citations

Multiple sites of action for noncompetitive blockers on acetylcholine receptor rich membrane fragments from Torpedo marmorata

1983 • 250 citations

Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by torpedo postsynaptic membranes: stoichiometry and ligand interactions

1979 • 243 citations

Myasthenia gravis induced by monoclonal antibodies to acetylcholine receptors

1980 • 201 citations

Affinity labeling of one of two α-neurotoxin binding sites in acetylcholine receptor from Torpedo californica

1978 • 163 citations

Bromoacetylcholine as an affinity label of the acetylcholine receptor from Torpedo californica

1978 • 160 citations

Monoclonal antibodies as probes of acetylcholine receptor structure. 2. Binding to native receptor

1981 • 157 citations

Characterization of Torpedo californica Acetylcholine Receptor: Its Subunit Composition and Ligand-binding Properties

1976 • 153 citations

Anti-acetylcholine receptor antibodies directed against the alpha-bungarotoxin binding site induce a unique form of experimental myasthenia.

1983 • 127 citations

Identification of a local anesthetic binding site in nicotinic post-synaptic membranes isolated from Torpedo marmorata electric tissue.

1979 • 120 citations

Protein-Ligand Interactions

1976 • 117 citations

Organization of ligand binding sites at the acetylcholine receptor: a study with monoclonal antibodies

1983 • 116 citations

Monoclonal anti-acetylcholine receptor antibodies can cause experimental myasthenia

1980 • 116 citations

Monoclonal anti-acetylcholine-receptor antibodies directed against the cholinergic binding site

1981 • 105 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 101 citations

Interaction of [125I]-.alpha.-bungarotoxin with acetylcholine receptor from Torpedo californica

1979 • 100 citations

Monoclonal antibodies against purified nicotinic acetylcholine receptor

1979 • 97 citations

Studies on the electrogenic action of acetylcholine with Torpedo marmorata electric organ

1976 • 92 citations

STRUCTURE AND FUNCTION OF THE ACETYLCHOLINE RECEPTOR MOLECULE STUDIED USING MONOCLONAL ANTIBODIES

1981 • 90 citations

Ligand specificity of state transitions in the cholinergic receptor: behavior of agonists and antagonists.

1979 • 89 citations

Studies of reversible and irreversible interactions of an alkylating agonist with Torpedo californica acetylcholine receptor in membrane-bound and purified states

1979 • 88 citations

Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor.

1981 • 83 citations

Fast Kinetic Studies on the Interaction of Cholinergic Agonists with the Membrane-Bound Acetylcholine Receptor from Torpedo marmorata as Revealed by Quinacrine Fluorescence

1977 • 76 citations

Friedreich ataxia

1982 • 73 citations

Monoclonal antibodies directed against the neurotransmitter binding site of nicotinic acetylcholine receptor

1980 • 70 citations

Monoclonal antibodies against defined determinants of acetylcholine receptor

1979 • 63 citations

Ligand-induced changes in membrane-bound acetylcholine receptor observed by ethidium fluorescence. 2. Stopped-flow studies with agonists and antagonists

1979 • 58 citations

Binding of perhydrohistrionicotoxin to intact and detergent-solubilized membranes enriched in nicotinic acetylcholine receptor

1979 • 58 citations

Multiple binding sites for agonists on Torpedo californica acetylcholine receptor

1982 • 53 citations

Kinetics of carbamylcholine binding to membrane-bound acetylcholine receptor monitored by fluorescence changes of a covalently bound probe

1980 • 51 citations

Interaction of cholinergic ligands with the purified acetylcholine receptor protein. II. Kinetic studies.

1983 • 47 citations

Primary structure and binding properties of iodinated derivatives of alpha-bungarotoxin.

1980 • 45 citations

Reaction of quinacrine mustard with the acetylcholine receptor from Torpedo californica.

1983 • 45 citations

Characterization of the activator site of Rhodospirillum rubrum ribulose bisphosphate carboxylase/oxygenase

1983 • 43 citations

Allosteric interactions of the membrane-bound acetylcholine receptor; kinetic studies with α-bungarotoxin

1975 • 38 citations

MONOCLONAL HYBRIDOMA ANTI‐ACETYLCHOLINE RECEPTOR ANTIBODIES: ANTIBODY SPECIFICITY AND EFFECT OF PASSIVE TRANSFER*

1981 • 25 citations

Spectrophotometric determination of fluorophor, protein, and fluorophor/protein ratios in fluorescamine and MDPF fluorescent antibody conjugates

1976 • 21 citations

Purification of high-affinity Fab fragments from experimental autoimmune Myasthenia gravis rabbits and their effect on isolated acetylcholine receptors

1979 • 17 citations

Myasthenia induced by monoclonal anti‐acetylcholine receptor antibodies: Clinical and electrophysiological aspects

1981 • 13 citations

Uses of fluorescent cholinergic analogs to study binding sites for cholinergic ligands in Torpedo californica acetylcholine receptor

1979 • 12 citations

Comparison of the interactions of a specific neurotoxin (.alpha.-bungarotoxin) with the acetylcholine receptor in Torpedo californica and Electrophorus electricus membrane preparations

1981 • 12 citations

Effect of anti-acetylcholine receptor Fab fragments from goats on functional membrane-bound receptor

1982 • 10 citations