Distinct Roles for Signals Relayed through the Common Cytokine Receptor γ Chain and Interleukin 7 Receptor α Chain in Natural T Cell Development

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Interleukin-2 receptor γ chain mutation results in X-linked severe combined immunodeficiency in humans

1993 • 1,317 citations

Generation and Analysis of Interleukin-4 Deficient Mice

1991 • 1,266 citations

An invariant T cell receptor alpha chain is used by a unique subset of major histocompatibility complex class I-specific CD4+ and CD4-8- T cells in mice and humans.

1994 • 1,044 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15.

1994 • 1,008 citations

Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting

1991 • 892 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Analysis of T cell antigen receptor (TCR) expression by human peripheral blood CD4-8- alpha/beta T cells demonstrates preferential use of several V beta genes and an invariant TCR alpha chain.

1993 • 714 citations

Interaction of IL-2Rβ and γ _c Chains with Jak1 and Jak3: Implications for XSCID and XCID

1994 • 647 citations

CD1d1 Mutant Mice Are Deficient in Natural T Cells That PromptlyProduce IL-4

1997 • 612 citations

Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

1993 • 510 citations

Immunoglobulin E Production in the Absence of Interleukin-4-Secreting CD1-Dependent Cells

1997 • 501 citations

Impaired NK1+ T Cell Development and Early IL-4 Production in CD1-Deficient Mice

1997 • 494 citations

A Subset of CD4 ⁺ Thymocytes Selected by MHC Class I Molecules

1994 • 464 citations

An invariant V alpha 24-J alpha Q/V beta 11 T cell receptor is expressed in all individuals by clonally expanded CD4-8- T cells.

1994 • 448 citations

NK1.1+ T cell receptor-alpha/beta+ cells: new clues to their origin, specificity, and function.

1995 • 355 citations

Major histocompatibility complex class I related molecules control the development of CD4+8- and CD4-8- subsets of natural killer 1.1+ T cell receptor-alpha/beta+ cells in the liver of mice.

1994 • 304 citations

Mouse NK1+ T cells

1995 • 292 citations

Selective reduction of V alpha 14+ NK T cells associated with disease development in autoimmune-prone mice.

1996 • 290 citations

Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4.

1995 • 237 citations

Mouse NK1.1+ T cells: a new family of T cells

1996 • 236 citations

The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms.

1993 • 219 citations

Sharing of the IL-2 receptor γ chain with the functional IL-9 receptor complex

1995 • 189 citations

Differential effects of interleukin-15 and interleukin-2 on differentiation of bipotential T/natural killer progenitor cells.

1996 • 162 citations

IL-15 can substitute for the marrow microenvironment in the differentiation of natural killer cells.

1996 • 148 citations

Role of the Common Cytokine Receptor γ Chain in Cytokine Signaling and Lymphoid Development

1995 • 143 citations

Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells

1996 • 119 citations

Interleukin (IL)-4-independent immunoglobulin class switch to immunoglobulin (Ig)E in the mouse.

1996 • 84 citations

Lineage Relationships and Differentiation of Natural Killer (NK) T Cells: Intrathymic Selection and Interleukin (IL)-4 Production in the Absence of NKR-P1 and Ly49 Molecules

1997 • 70 citations

IL-7 reverses NK1⁺ Tcell-defective IL-4 production in the non-obese diabetic mouse

1996 • 69 citations

Development of Valpha4+ NK T cells in the early stages of embryogenesis.

1996 • 52 citations

NK1.1⁺ T cells from IL-7-deficient mice have a normal distribution and selection but exhibit impaired cytokine production

1996 • 44 citations

Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice.

1996 • 42 citations

Interleukin 7 induces preferential expansion of V beta 8.2+CD4-8- and V beta 8.2+CD4+8- murine thymocytes positively selected by class I molecules.

1994 • 30 citations

Dysregulated expression of the IL-2 receptor β-chain abrogates development of NK cells and Thy-1⁺ dendritic epidermal cells in transgenic mice

1995 • 22 citations

Expression and role of interleukin‐2 receptor β chain on CD4⁻CD8⁺ T cell receptor αβ⁺ cells

1992 • 16 citations