Cystic fibrosis: A review of pulmonary infections and interventions

Manual of Clinical Microbiology

1970 • 2,775 citations

Pseudomonas cepacia infection in cystic fibrosis: An emerging problem

1984 • 850 citations

Correlation between Serum IgG-2 Concentrations and the Antibody Response to Bacterial Polysaccharide Antigens

1980 • 472 citations

STUDIES ON HUMAN ANTIBODIES

1968 • 435 citations

A rat model of chronic respiratory infection with Pseudomonas aeruginosa.

1979 • 332 citations

Recurrent Sinopulmonary Infection and Impaired Antibody Response to Bacterial Capsular Polysaccharide Antigen in Children with Selective IgG-Subclass Deficiency

1985 • 308 citations

ALTERNATE-DAY PREDNISONE REDUCES MORBIDITY AND IMPROVES PULMONARY FUNCTION IN CYSTIC FIBROSIS

1985 • 305 citations

NALOXONE AS AN ANTAGONIST IN SEVERE ALCOHOL INTOXICATION

1978 • 296 citations

EXPENDITURE ON N.H.S. PRACTICE PREMISES. THE MINISTER'S LETTER.

1964 • 293 citations

Once-Daily vs. Continuous Aminoglycoside Dosing: Efficacy and Toxicity in Animal and Clinical Studies of Gentamicin, Netilmicin, and Tobramycin

1983 • 288 citations

AEROSOL CARBENICILLIN AND GENTAMICIN TREATMENT OF PSEUDOMONAS AERUGINOSA INFECTION IN PATIENTS WITH CYSTIC FIBROSIS

1981 • 280 citations

Perspectives in Cystic Fibrosis

1979 • 276 citations

Allergic bronchopulmonary aspergillosis in cystic fibrosis

1984 • 273 citations

Antimicrobial susceptibility of five subgroups of Mycobacterium fortuitum and Mycobacterium chelonae

1985 • 262 citations

Pseudomonas cepacia colonization in patients with cystic fibrosis: Risk factors and clinical outcome

1985 • 247 citations

Antiphagocytic Effect of Slime from a Mucoid Strain of Pseudomonas aeruginosa

1971 • 242 citations

FREQUENT ANTIBIOTIC THERAPY IMPROVES SURVIVAL OF CYSTIC FIBROSIS PATIENTS WITH CHRONIC PSEUDOMONAS AERUGINOSA INFECTION

1983 • 241 citations

MICROBIOLOGY OF LUNG INFECTIONS IN CYSTIC FIBROSIS PATIENTS

1982 • 234 citations

Association of Respiratory Viral Infections with Pulmonary Deterioration in Patients with Cystic Fibrosis

1984 • 233 citations

Aminoglycoside penetration, inactivation, and efficacy in cystic fibrosis sputum.

1985 • 220 citations

Therapy of Spontaneous Metastases by Intravenous Injection of Liposomes Containing Lymphokines

1980 • 204 citations

Pulmonary Disease Associated with Pseudomonas aeruginosa in Cystic Fibrosis: Current Status of the Host-Bacterium Interaction

1985 • 200 citations

Granulocyte Neutral Proteases and Pseudomonas Elastase as Possible Causes of Airway Damage in Patients with Cystic Fibrosis

1984 • 196 citations

Role of Adherence in the Pathogenesis of Pseudomonas aeruginosa Lung Infection in Cystic Fibrosis Patients

1980 • 189 citations

RESPIRATORY INFECTIONS IN CYSTIC FIBROSIS PATIENTS CAUSED BY VIRUS, CHLAMYDIA AND MYCOPLASMA–POSSIBLE SYNERGISM WITH PSEUDOMONAS AERUGINOSA

1981 • 184 citations

Natural Infection of Man with Group A Streptococci

1976 • 179 citations

Adherence of Pseudomonas aeruginosa to tracheal cells injured by influenza infection or by endotracheal intubation

1980 • 175 citations

Untersuchungen über die O-Antigene von Pseudomonas aeruginosa

1957 • 171 citations

Pseudomonas aeruginosa : clinical manifestations of infection and current therapy

1979 • 159 citations

Epidemiology of Endemic Pseudomonas aeruginosa: Why Infection Control Efforts Have Failed

1984 • 157 citations

Evidence for mucins and sialic acid as receptors for Pseudomonas aeruginosa in the lower respiratory tract

1983 • 151 citations

Comparison of plasmid profile analysis, phage typing, and antimicrobial susceptibility testing in characterizing Salmonella typhimurium isolates from outbreaks

1984 • 150 citations

Totally implanted system for intravenous chemotherapy in patients with cancer

1982 • 147 citations

Multiple Isolates of Pseudomonas aeruginosa with Differing Antimicrobial Susceptibility Patterns from Patients with Cystic Fibrosis

1979 • 142 citations

Pseudomonas aeruginosa Infections: Persisting Problems and Current Research to Find New Therapies

1975 • 134 citations

Hypogammaglobulinemia in Patients with Cystic Fibrosis

1980 • 129 citations

Evaluation of jet nebulisers for use with gentamicin solution.

1985 • 127 citations

Further Studies In The Pyocine Typing Of Pseudomonas Pyocyanea

1969 • 127 citations

Adherence of Pseudomonas aeruginosa to human tracheobronchial mucin

1984 • 126 citations

Clinical and Bacteriological Responses to Three Antibiotic Regimens for Acute Exacerbations of Cystic Fibrosis: Tlcarcillln-Tobramycin, Azlocillin-Tobramycin, and Azlocillin-Placebo

1983 • 124 citations

Molecular Analysis of R-Factors from Multiresistant Nosocomial Isolates

1980 • 112 citations

Prospective, controlled study of a polyvalent pseudomonas vaccine in cystic fibrosis--three year results.

1984 • 112 citations

Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: A 5-year longitudinal study

1984 • 109 citations

IgG Proteolytic Activity of Pseudomonas aeruginosa in Cystic Fibrosis

1985 • 107 citations

Is anti-Pseudomonas therapy warranted in acute respiratory exacerbations in children with cystic fibrosis?

1980 • 106 citations

Serogroups of Pseudomonas aeruginosa and the Immune Response of Patients with Cystic Fibrosis

1970 • 105 citations

Proteases of Pseudomonas aeruginosa in Patients with Cystic Fibrosis

1983 • 104 citations

Use of agarose gel electrophoresis of plasmid deoxyribonucleic acid to fingerprint gram-negative bacilli

1981 • 100 citations

The Identification of Atypical Strains of Pseudomonas aeruginosa

1965 • 99 citations

Cultures of thoracotomy specimens confirm usefulness of sputum cultures in cystic fibrosis

1984 • 98 citations

Epidemiology of Pseudomonas aeruginosa infection and the role of contamination of the environment in a cystic fibrosis clinic

1983 • 96 citations

Proteinases of Pseudomonas aeruginosa evoke mucin release by tracheal epithelium.

1984 • 95 citations

Antibiotic prophylaxis in cystic fibrosis: Inhaled cephaloridine as an adjunct to oral cloxacillin

1982 • 95 citations

Isolation medium for the recovery of Pseudomonas cepacia from respiratory secretions of patients with cystic fibrosis

1985 • 93 citations

DISSOCIATION IN PSEUDOMONAS AERUGINOSA

1964 • 92 citations

ANTIMICROBIAL CHEMOTHERAPY IN CYSTIC FIBROSIS PATIENTS

1982 • 91 citations

A Totally Implanted Injection Port System for Blood Sampling and Chemotherapy Administration

1984 • 89 citations

A double-blind controlled trial of anti-Pseudomonas chemotherapy of acute respiratory exacerbations in patients with cystic fibrosis

1981 • 87 citations

IgG1 is the predominant subclass ofin vivo- andin vitro-produced anti-tetanus toxoid antibodies and also serves as the membrane IgG molecule for delivering inhibitory signals to anti-tetanus toxoid antibody-producing B cells

1983 • 84 citations

Occurrence and antimicrobial susceptibility of gram-negative nonfermentative bacilli in cystic fibrosis patients

1985 • 82 citations

INHIBITORY EFFECT OF CYSTIC FIBROSIS SERUM ON PSEUDOMONAS PHAGOCYTOSIS BY RABBIT AND HUMAN ALVEOLAR MACROPHAGES

1979 • 81 citations

Ceftazidime alone and in combination in patients with cystic fibrosis: lack of efficacy in treatment of severe respiratory infections caused by Pseudomonas cepacia

1983 • 78 citations

Heterogeneity of antibiotic resistance in mucoid isolates of Pseudomonas aeruginosa obtained from cystic fibrosis patients: role of outer membrane proteins

1981 • 78 citations

Isolation of rapidly growing mycobacteria in patients with cystic fibrosis

1980 • 76 citations

Cystic fibrosis pseudomonas opsonins. Inhibitory nature in an in vitro phagocytic assay.

1981 • 76 citations

Studies on the Ability of Alginate to Act as a Protective Immunogen Against Infection with Pseudomonas aeruginosa in Animals

1985 • 74 citations

Toxicity of Pseudomonas aeruginosa exotoxin A for human macrophages

1978 • 74 citations

Depression of Human Monocyte Chemotaxis by Herpes Simplex and Influenza Viruses

1974 • 74 citations

Controlled trial of ceftazidime vs. ticarcillin and tobramycin in the treatment of acute respiratory exacerbations in patients with cystic fibrosis

1985 • 73 citations

In vitro inhibition of lymphocyte proliferation by Pseudomonas aeruginosa phenazine pigments

1983 • 69 citations

The nephropathy of cystic fibrosis: A human model of chronic nephrotoxicity

1982 • 63 citations

Ultrastructure and Function of Alveolar Macrophages from Cystic Fibrosis Patients

1980 • 63 citations

Serotyping of Pseudomonas aeruginosa isolates from patients with cystic fibrosis of the pancreas

1975 • 60 citations

Active Immunization with Lipopolysaccharide Pseudomonas Antigen for Chronic Pseudomonas Bronchopneumonia in Guinea Pigs

1981 • 59 citations

Activities of various beta-lactams and aminoglycosides, alone and in combination, against isolates of Pseudomonas aeruginosa from patients with cystic fibrosis

1982 • 58 citations

DOES PSEUDOMONAS CROSS-INFECTION OCCUR BETWEEN CYSTIC FIBROSIS PATIENTS?

1982 • 56 citations

Ceftazidime treatment of chronic Pseudomonas aeruginosa respiratory tract infection in cystic fibrosis

1983 • 55 citations

Communicability of Pseudomonas aeruginosa in a cystic fibrosis summer camp

1982 • 55 citations

Importance of viruses and Legionella pneumophila in respiratory exacerbations of young adults with cystic fibrosis.

1984 • 54 citations

Serum bactericidal effect on Pseudomonas aeruginosa isolates from cystic fibrosis patients

1981 • 53 citations

Pseudomonas aeruginosa colonisation in an intensive therapy unit: role of cross infection and host factors.

1983 • 52 citations

Immune complexes and humoral response to Pseudomonas aeruginosa in cystic fibrosis.

1980 • 51 citations

Circulating Immune Complexes in Cystic Fibrosis

1980 • 49 citations

Imipenem/Cilastatin in Acute Pulmonary Exacerbations of Cystic Fibrosis

1985 • 48 citations

Serological properties of Pseudomonas aeruginosa. II. Type-specific thermolabile (flagellar) antigens.

1970 • 48 citations

Phage Typing of Pseudomonas aeruginosai Clinical and Epidemiologic Considerations

1974 • 46 citations

Cellular immunity to bacteria: impairment of in vitro lymphocyte responses to Pseudomonas aeruginosa in cystic fibrosis patients

1977 • 46 citations

Evaluation of the Safety of Amantadine. HCI and the Role of Respiratory Viral Infections in Children with Cystic Fibrosis

1976 • 46 citations

Association with phagocytic inhibition of anti-Pseudomonas aeruginosa immunoglobulin G antibody subclass levels in serum from patients with cystic fibrosis

1986 • 45 citations

Ceftazidime therapy in patients with cystic fibrosis and multiply-drug-resistant pseudomonas

1985 • 44 citations

Immunological aspects of cystic fibrosis.

1967 • 43 citations

Lymphocyte responsiveness to Pseudomonas aeruginosa in cystic fibrosis: Relationship to status of pulmonary disease in sibling pairs

1978 • 43 citations

In vitro T cell-mediated killing of Pseudomonas aeruginosa. II. The role of macrophages and T cell subsets in T cell killing.

1985 • 43 citations

Bactericidal Synergism Between -Lactams and Aminoglycosides: Mechanism and Possible Therapeutic Implications

1982 • 42 citations

The production and inactivation of pyocines

1963 • 42 citations

Nursery Outbreak of Pseudomonas aeruginosa : Epidemiological Conclusions from Five Different Typing Methods

1973 • 39 citations

Pulmonary and Systemic Defenses against Challenge with Staphylococcus aureus in Mice with Pneumonia Due to Influenza A Virus

1979 • 39 citations

IMMUNE COMPLEX MEDIATED TISSUE DAMAGE IN THE LUNGS OF CYSTIC FIBROSIS PATIENTS WITH CHRONIC PSEUDOMONAS AERUGINOSA INFECTION

1982 • 38 citations

Defective cellular immunity to gram-negative bacteria in cystic fibrosis patients

1979 • 37 citations

Immunotherapeutic potential of monoclonal antibodies againstPseudomonas aeruginosa protein F

1985 • 35 citations

Transtracheal aspiration in pulmonary infection in children with cystic fibrosis.

1983 • 35 citations

Chapter III Pyocin Typing of Pseudornonas aeruginosa

1978 • 35 citations

Alteration of the immunoglobulin G subclass responses in mice to lipopolysaccharide: effects of nonbacterial proteins and bacterial membrane phospholipids or outer membrane proteins of Proteus mirabilis

1983 • 34 citations

Isolation and characterization of circulating immune complexes in cystic fibrosis.

1982 • 34 citations

Increased dosage requirements of tobramycin and gentamicin for treating Pseudomonas pneumonia in patients with cystic fibrosis

1985 • 34 citations

Evolving epidemiology ofPseudomonas aeruginosa infections

1985 • 34 citations

SEROLOGICAL COMPARISON BETWEEN STRAINS OF PSEUDOMONAS AERUGINOSA FROM HUMAN AND ANIMAL SOURCES

1960 • 33 citations

Pseudomonas aeruginosa isolates: Comparisons of isolates from campers and from sibling pairs with cystic fibrosis

1985 • 33 citations

Azlocillin with and without an aminoglycoside against respiratory tract infections in children with cystic fibrosis.

1981 • 30 citations

Pharmacokinetics of imipenem and cilastatin in patients with cystic fibrosis

1985 • 30 citations

Ibuprofen modifies the inflammatory response of the murine lung to Pseudomonas aeruginosa.

1985 • 30 citations

In-vitro activity of ciprofioxacin and other antibacterial agents against Pseudonwnas aeruginosa and Pseudomonas cepacia from cystic fibrosis patients

1985 • 30 citations

Staphylococcus aureus: Biology, mechanisms of virulence, epidemiology

1986 • 29 citations

Protective immunization against chronic Pseudomonas aeruginosa pulmonary infection in rats

1983 • 29 citations

Pseudomonas cepacia Colonization among Patients with Cystic Fibrosis

2015 • 28 citations

Pulmonary cellular response to chronic irritation and chronic Pseudomonas aeruginosa pneumonia in cats

1984 • 26 citations

Induction of phagocytic inhibitory activity in cats with chronic Pseudomonas aeruginosa pulmonary infection

1982 • 25 citations

Textbook of cystic fibrosis

1984 • 25 citations

Symptomatic hypomagnesemia in cystic fibrosis

1985 • 25 citations

Suppression of Antibacterial Immunity by Infection with Influenza Virus

1981 • 24 citations

Changes in lymphocyte reactivity to Pseudomonas aeruginosa in hospitalized patients with cystic fibrosis.

1981 • 23 citations

Interaction of pseudomonas exoproducts with phagocytic cells

1982 • 23 citations

PSEUDOMONAS CEPACIA IN THE RESPIRATORY FLORA OF PATIENTS WITH CYSTIC FIBROSIS (CF)

1977 • 23 citations

Antimicrobial Therapy of Pseudomonas Pulmonary Exacerbations in Cystic Fibrosis

1986 • 22 citations

Randomized, double-blind evaluation of azlocillin for the treatment of pulmonary exacerbations of cystic fibrosis

1983 • 22 citations

Simplified Method for Producing Pyocins from Pseudomonas aeruginosa

1973 • 21 citations

Monoklonale Antikörper: Technologie und Anwendung bei gramnegativen Infektionen

1984 • 21 citations

PSEUDOMONAS AERUGINOSA INFECTION IN CYSTIC FIBROSIS:

1977 • 21 citations

A totally implanted injection port system for blood sampling and chemotherapy administration

1984 • 19 citations

Immune Complexes and Complement Abnormalities in Patients with Cystic Fibrosis

2015 • 19 citations

Incidence and risk of cross-colonization in cystic fibrosis holiday camps

1980 • 16 citations

SYSTEMIC AND MUCOSAL IMMUNITY AND NON-SPECIFIC DEFENSE MECHANISMS IN CYSTIC FIBROSIS PATIENTS

1982 • 16 citations

Use of a "Heparin Lock" in the Intermittent Adminstration of Intravenous Drugs

1972 • 15 citations

B-lymphocyte function in cystic fibrosis.

1983 • 14 citations

Influence of Cystic Fibrosis Plasma on Lymphocyte Responses to Pseudomonas Aeruginosa In Vitro

1981 • 13 citations

Pulmonary candidiasis in cystic fibrosis.

1979 • 13 citations

Peripherally inserted central venous catheters for treatment of cystic fibrosis

1985 • 13 citations

The role of piperacillin therapy in pulmonary exacerbations of cystic fibrosis: A controlled study

1985 • 12 citations

Comparison of the Minitek system with conventional methods for identification of nonfermentative and oxidase-positive fermentative gram-negative bacilli

1979 • 11 citations

Cephalosporin therapeutics in cystic fibrosis

1986 • 11 citations

An overview of the management of cystic fibrosis.

1986 • 10 citations

Comparative in vitro activities of azlocillin-cefotaxime and azlocillin-tobramycin combinations against blood and multi-drug resistant bacterial isolates

1982 • 10 citations

Microtiter immunoenzymatic assay (Micro-ELISA) for antigen specific IgG4 subclass antibody

1983 • 9 citations

Ceftazidime--a significant advance in the treatment of cystic fibrosis

1983 • 9 citations

Cefoperazone against carbenicillin- resistant isolates of Pseudomonas aeruginosa: comparison with other newer cephalosporins and N-formimidoyl thienamycin

1983 • 9 citations

Evaluation of 36 Minitek tests and a new approach for identification of nonfermenters

1981 • 9 citations

The Activity of Ceftazidime, Other <i>β</i>-Lactams, and Aminoglycosides against <i>Pseudomonas aeruginosa</i>

1984 • 9 citations

Epidemiology of Pseudomonas aeruginosa infections investigated by pyocin typing.

1975 • 7 citations

Phagocytic inhibitory activity in serum of cats immunized withPseudomonas aeruginosa lipopolysaccharide

1985 • 7 citations

Monoklonale Antikörper: Technologie und Anwendung bei gramnegativen Infektionen

1985 • 7 citations

Function of Human Alveolar Macrophages From Normal Volunteers and Cigarette Smokers: Effect of Cystic Fibrosis Serum

1984 • 5 citations

Dissociation in Pseudomonas aeruginosa

1968 • 5 citations

TEICHOIC ACID SEROLOGY IN VARIOUS STAPHYLOCOCCAL COAGULASE POSITIVE INFECTIONS IN INFANTS AND CHILDREN

1977 • 4 citations

Subtyping of Pyocin Type 1 Pseudomonas aeruginosa : One Year of Experience

1971 • 4 citations

Lack of development of phagocytic inhibitory activity in serum of cats immunized withEnterobacter cloacae lipopolysaccharide

1987 • 1 citations