Kinetics of the reactions of hypochlorous acid and amino acid chloramines with thiols, methionine, and ascorbate

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Oxidation of methionyl residues in proteins: Tools, targets, and reversal

1995 • 860 citations

Reactivity of biologically important thiol compounds with superoxide and hydrogen peroxide

1999 • 769 citations

Redox regulation of transcriptional activators

1996 • 690 citations

Myeloperoxidase: a key regulator of neutrophil oxidant production

1997 • 641 citations

Comparative reactivities of various biological compounds with myeloperoxidase-hydrogen peroxide-chloride, and similarity of oxidant to hypochlorite

1985 • 459 citations

Biological reactivity of hypochlorous acid: implications for microbicidal mechanisms of leukocyte myeloperoxidase.

1981 • 443 citations

Chlorination of endogenous amines by isolated neutrophils. Ammonia-dependent bactericidal, cytotoxic, and cytolytic activities of the chloramines.

1984 • 397 citations

Evidence of oxidant-induced injury to epithelial cells during inflammatory bowel disease.

1996 • 349 citations

[40] Preparation and characterization of chloramines

1986 • 345 citations

Kinetics and Mechanisms of Hypochlorous Acid Reactions

1995 • 330 citations

The chemistry and biochemistry of the sulfhydryl group in amino acids, peptides, and proteins

1973 • 327 citations

Hypochlorous Acid Interactions with Thiols, Nucleotides, DNA, and Other Biological Substrates

1996 • 311 citations

Mechanisms of hypochlorite injury of target cells.

1990 • 261 citations

Myeloperoxidase

2000 • 261 citations

[53] Assays for the chlorination activity of myeloperoxidase

1994 • 260 citations

Chlorohydrin formation from unsaturated fatty acids reacted with hypochlorous acid

1992 • 255 citations

Sensitivity of the Essential Zinc-Thiolate Moiety of Yeast Alcohol Dehydrogenase to Hypochlorite and Peroxynitrite

1995 • 246 citations

Generation of nitrogen-chlorine oxidants by human phagocytes.

1984 • 156 citations

Taurine and Hypotaurine Content of Human Leukocytes

1990 • 153 citations

Characterization of the oxidation products of the reaction between reduced glutathione and hypochlorous acid

1997 • 143 citations

Aqueous chemistry of N-halo-compounds

1998 • 127 citations

Interactions of Hypochlorous Acid with Pyrimidine Nucleotides, and Secondary Reactions of Chlorinated Pyrimidines with GSH, NADH, and Other Substrates

1998 • 119 citations

First Steps in the Oxidation of Sulfur-Containing Amino Acids by Hypohalogenation: Very Fast Generation of Intermediate Sulfenyl Halides and Halosulfonium Cations

2000 • 108 citations

Oxidation of neutrophil glutathione and protein thiols by myeloperoxidase-derived hypochlorous acid

1997 • 104 citations

Loss of GSH and thiol enzymes in endothelial cells exposed to sublethal concentrations of hypochlorous acid

1999 • 103 citations

Hypochlorous acid and chloramines increase endothelial permeability: possible involvement of cellular zinc

1994 • 93 citations

Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells

1999 • 93 citations

Ion‐Pair Formation as a Source of Enhanced Reactivity of the Essential Thiol Group of <scp>d</scp>‐Glyceraldehyde‐3‐Phosphate Dehydrogenase

1975 • 76 citations

Hypochlorous acid activates the heat shock and soxRS systems of Escherichia coli

1996 • 75 citations

On the Irreversible Destruction of Reduced Nicotinamide Nucleotides by Hypohalous Acids

2000 • 66 citations

Reactions of Hypochlorous Acid with Biological Substrates Are Activated Catalytically by Tertiary Amines

1998 • 64 citations

Oxidation of proteins in rat heart and lungs by polymorphonuclear leukocyte oxidants

1988 • 62 citations

Initiation of Rapid, P53-Dependent Growth Arrest in Cultured Human Skin Fibroblasts by Reactive Chlorine Species

2000 • 53 citations

Impairment of cardiac contractility and sarcoplasmic reticulum Ca²⁺ ATPase activity by hypochlorous acid: reversal by dithiothreitol

1991 • 51 citations

Hypochlorous Acid Activates the Tumor Suppressor Protein p53 in Cultured Human Skin Fibroblasts

1998 • 46 citations

Kinetic study of the decomposition ofN-chloramines

1996 • 35 citations

Hypochlorous acid causes caspase activation and apoptosis or growth arrest in human endothelial cells

1999 • 34 citations

Calcium homeostasis in rabbit ventricular myocytes. Disruption by hypochlorous acid and restoration by dithiothreitol.

1991 • 34 citations

Biochemical mechanisms of hydrogen peroxide- and hypochlorous acid-mediated inhibition of human mononuclear leukocyte functionsin vitro: Protection and reversal by anti-oxidants

1992 • 28 citations

Dithiothreitol restores contractile function to oxidant-injured cardiac muscle

1989 • 28 citations

Hypochlorous Acid Mobilizes Intracellular Zinc in Isolated Rat Heart Myocytes

1994 • 20 citations

[30] Reaction of (R,S)-dihydrolipoic acid and homologs with iron

1995 • 7 citations