Can we screen high-risk individuals to detect early pancreatic carcinoma?

Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

1994 • 7,043 citations

Serial Analysis of Gene Expression

1995 • 3,659 citations

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

1988 • 2,121 citations

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1996 • 2,002 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

Aspirin Use and Reduced Risk of Fatal Colon Cancer

1991 • 1,695 citations

Gene Expression Profiles in Normal and Cancer Cells

1997 • 1,157 citations

Hereditary Pancreatitis and the Risk of Pancreatic Cancer

1997 • 968 citations

Aberrant methylation of p16 ^INK4a is an early event in lung cancer and a potential biomarker for early diagnosis

1998 • 953 citations

Pancreaticoduodenectomy for Cancer of the Head of the Pancreas 201 Patients

1995 • 950 citations

Aspirin use and risk of fatal cancer.

1993 • 884 citations

Increased Risk of Cancer in the Peutz–Jeghers Syndrome

1987 • 865 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

K-ras oncogene activation in adenocarcinoma of the human pancreas. A study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotide hybridization.

1993 • 656 citations

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.

1996 • 637 citations

Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16^INK4Mutations

1995 • 620 citations

Staging of pancreatic and ampullary carcinoma by endoscopic ultrasonography

1992 • 533 citations

Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer.

1998 • 413 citations

Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.

1999 • 405 citations

Hypermethylation of multiple genes in pancreatic adenocarcinoma.

2000 • 404 citations

Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer

1999 • 398 citations

Early Diagnosis and Treatment of Pancreatic Dysplasia in Patients with a Family History of Pancreatic Cancer

1999 • 392 citations

Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia.

1994 • 369 citations

Reduced Risk of Large-Bowel Adenomas Among Aspirin Users

1993 • 301 citations

Aspirin and reduced risk of esophageal carcinoma

1995 • 290 citations

Use of Nonsteroidal Anti-inflammatory Drugs and Incidence of Colorectal Cancer

1999 • 265 citations

Islet Amyloid Polypeptide in Patients with Pancreatic Cancer and Diabetes

1994 • 234 citations

Optimal interpretation of FDG PET in the diagnosis, staging and management of pancreatic carcinoma.

1999 • 222 citations

A prospective study of K-ras mutations in the plasma of pancreatic cancer patients.

1998 • 207 citations

Reported family aggregation of pancreatic cancer within a population-based case-control study in the francophone community in Montreal, Canada

1991 • 197 citations

Genetics of Pancreatic Cancer

1998 • 193 citations

Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma

1998 • 162 citations

Detection of K-ras gene mutations in plasma DNA of patients with pancreatic adenocarcinoma: correlation with clinicopathological features.

1998 • 159 citations

Intensified adjuvant therapy for pancreatic and periampullary adenocarcinoma: survival results and observations regarding patterns of failure, radiotherapy dose and CA19-9 levels

1999 • 111 citations

K-ras mutations in the duodenal fluid of patients with pancreatic carcinoma

1998 • 111 citations

Human telomerase reverse transcriptase (hTERT) gene expression in thyroid neoplasms.

1999 • 97 citations

CA 19-9 in Pancreatic Cancer

1998 • 94 citations

The role ofras mutation in pancreatic cancer, precancerous lesions, and chronic pancreatitis

1993 • 82 citations

Pathology of incipient pancreatic cancer

1999 • 74 citations

Telomerase activity in pancreatic juice differentiates ductal carcinoma from adenoma and pancreatitis.

1997 • 73 citations

Telomerase activity in lesions of the thyroid: application to diagnosis of clinical samples including fine-needle aspirates.

1998 • 65 citations

Mutational activation of K-ras in nonneoplastic exocrine pancreatic lesions in relation to cigarette smoking status

1999 • 65 citations

Telomerase Activity for the Preoperative Diagnosis of Pancreatic Cancer

1997 • 58 citations

Telomerase activity in the differential diagnosis of papillary carcinoma of the thyroid

1997 • 57 citations

Usefulness of novel tumour markers

1999 • 47 citations

In situ hybridization for telomerase RNA in routine cytologic brushings for the diagnosis of pancreaticobiliary malignancies

1998 • 47 citations

Telomerase activity detected in pancreatic juice 19 months before a tumor is detected in a patient with pancreatic cancer

1998 • 44 citations

Detection of telomerase activity in breast masses by fine-needle aspiration

1998 • 23 citations

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1999 • 22 citations

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1999 • 18 citations

Role of tumor markers and mutations in cells and pancreatic juice in the diagnosis of pancreatic cancer

1999 • 14 citations

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1999 • 5 citations