Antigen-driven long term-cultured T cells proliferate in vivo, distribute widely, mediate specific tumor therapy, and persist long-term as functional memory T cells.

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

A cell-surface molecule involved in organ-specific homing of lymphocytes

1983 • 1,515 citations

Treatment of B-Cell Lymphoma with Monoclonal Anti-Idiotype Antibody

1982 • 1,001 citations

Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2.

1985 • 737 citations

Cyclophosphamide-facilitated adoptive immunotherapy of an established tumor depends on elimination of tumor-induced suppressor T cells.

1982 • 640 citations

T-cell clones specific for myelin basic protein induce chronic relapsing paralysis and demyelination

1985 • 522 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

T-T-cell interactions during the vitro cytotoxic allograft responses. I. Soluble products from activated Lyl+ T cells trigger autonomously antigen-primed Ly23+ T cells to cell proliferation and cytolytic activity.

1978 • 330 citations

Eradication of disseminated murine leukemia by chemoimmunotherapy with cyclophosphamide and adoptively transferred immune syngeneic Lyt-1+2- lymphocytes.

1981 • 317 citations

Biology of cloned cytotoxic T lymphocytes specific for lymphocytic choriomeningitis virus: clearance of virus in vivo

1984 • 296 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2.

1982 • 267 citations

Alloreactive cloned T cell lines. I. Interactions between cloned amplifier and cytolytic T cell lines.

1980 • 235 citations

Monoclonal antibodies define differential ras gene expression in malignant and benign colonic diseases

1984 • 226 citations

The in vivo distribution of autologous human and murine lymphoid cells grown in T cell growth factor (TCGF): implications for the adoptive immunotherapy of tumors.

1980 • 223 citations

Abnormal migration of T lymphocyte clones.

1982 • 153 citations

Specific adoptive therapy of established leukemia with syngeneic lymphocytes sequentially immunized in vivo and in vitro and nonspecifically expanded by culture with Interleukin 2.

1981 • 130 citations

Clones of helper T cells mediate antigen-specific, H–2-restricted DTH

1981 • 112 citations

Interleukin 2 administered in vivo induces the growth of cultured T cells in vivo.

1984 • 100 citations

Allogeneic tumor rejection induced by the intravenous injection of Lyt-2+ cytolytic T lymphocyte clones.

1982 • 85 citations

Interleukin 2 (IL 2) administered in vivo: influence of IL 2 route and timing on T cell growth.

1985 • 84 citations

Generation of an HLA-restricted cytotoxic T cell line reactive against cultured tumor cells from a patient infected with human T cell leukemia/lymphoma virus.

1983 • 80 citations

Treatment of disseminated leukemia with cyclophosphamide and immune cells: tumor immunity reflects long-term persistence of tumor-specific donor T cells.

1984 • 67 citations

Specific adoptive immunotherapy with tumor-specific cytotoxic T-lymphocyte clone for murine malignant gliomas.

1984 • 64 citations

In Vivo Elimination by Specific Effector Cells of an Established Syngeneic Rat Moloney Virus-Induced Sarcoma

1979 • 62 citations

The in vivo behavior of T cell clones: altered migration due to loss of the lymphocyte surface homing receptor.

1985 • 53 citations

The In Vitro Generation of Effector Lymphocytes and Their Employment in Tumor Immunotherapy

1983 • 51 citations

Detection of early and delayed antitumor effects following curative adoptive chemoimmunotherapy of established leukemia.

1980 • 49 citations

Lymphocyte Circulation: experimental and Clinical Aspects

1982 • 48 citations

Genetic Control of the Immune Response to Thy‐1 Antigens¹

1978 • 47 citations

MODELS FOR SYNGENEIC ADOPTIVE CHEMOIMMUNOTHERAPY OF MURINE LEUKEMIAS*

1976 • 47 citations

Lymphocyte circulation: Experimental and clinical aspects

1981 • 45 citations

Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen.

1985 • 44 citations

Oxygen radical detoxification enzymes in doxorubicin-sensitive and -resistant P388 murine leukemia cells.

1984 • 42 citations

Activation of Lyt-1+ and Lyt-2+ T cell cloned lines: stimulation of proliferation, lymphokine production, and self-destruction.

1985 • 36 citations

Generation of Lytic and Proliferative Lymphoid Clones to Syngeneic Tumor: In Vitro and In Vivo Studies

1984 • 34 citations

In vivo Localization of cloned IL-2-Dependent T cells

1983 • 32 citations

H-2 restriction of adoptive immunotherapy of advanced tumors.

1981 • 32 citations

Characterization of interleukin 2 (IL-2)-dependent cytotoxic T-cell clones

1984 • 19 citations

Studies on chemically induced rat tumors. II. Partial protection against syngeneic lethal tumors by cloned syngeneic cytotoxic T lymphocytes

1983 • 13 citations