Can there be a more patient-centred approach to determining clinically important effect sizes for randomized treatment trials?

The Framing of Decisions and the Psychology of Choice

1981 • 16,265 citations

Clinical Epidemiology: A Basic Science for Clinical Medicine.

1991 • 3,572 citations

On the Elicitation of Preferences for Alternative Therapies

1982 • 1,664 citations

The Importance of Beta, the Type II Error and Sample Size in the Design and Interpretation of the Randomized Control Trial

1978 • 1,634 citations

MEDICAL SCIENCE GISSI-2: A factorial randomised trial of alteplase versus streptokinase and heparin versus no heparin among 12 490 patients with acute myocardial infarction

1990 • 911 citations

ISIS-3 - A RANDOMIZED COMPARISON OF STREPTOKINASE VS TISSUE PLASMINOGEN-ACTIVATOR VS ANISTREPLASE AND OF ASPIRIN PLUS HEPARIN VS ASPIRIN ALONE AMONG 41,299 CASES OF SUSPECTED ACUTE MYOCARDIAL-INFARCTION

1992 • 898 citations

ISIS-3: a randomised comparison of streptokinase vs tissue plasminogen activator vs anistreplase and of aspirin plus heparin vs aspirin alone among 41 299 cases of suspected acute myocardial infarction

1992 • 866 citations

Attitudes to chemotherapy: comparing views of patients with cancer with those of doctors, nurses, and general public.

1990 • 768 citations

Clinical Epidemiology: A Basic Science for Clinical Medicine.

1985 • 762 citations

Why do we need some large, simple randomized trials?

1984 • 692 citations

The utility of different health states as perceived by the general public

1978 • 667 citations

Clinical Epidemiology - a basic science for clinical medicine

1992 • 629 citations

In-hospital mortality and clinical course of 20 891 patients with suspected acute myocardial infarction randomised between alteplase and streptokinase with or without heparin

1990 • 612 citations

Fallacy of the Five-Year Survival in Lung Cancer

1978 • 477 citations

A Scale of Valuations of States of Illness: is there a Social Consensus?

1978 • 468 citations

Measured Enthusiasm: Does the Method of Reporting Trial Results Alter Perceptions of Therapeutic Effectiveness?

1992 • 378 citations

Whose Utilities for Decision Analysis?

1990 • 372 citations

Absolutely relative: How research results are summarized can affect treatment decisions

1992 • 335 citations

Patients' willingness to enter clinical trials: Measuring the association with perceived benefit and preference for decision participation

1991 • 241 citations

When Was a 'Negative' Clinical Trial Big Enough?

1985 • 214 citations

Indexes and boundaries for “quantitative significance” in statistical decisions

1990 • 204 citations

Effects of framing and level of probability on patients' preferences for cancer chemotherapy

1989 • 168 citations

Eliciting preferences for alternative drug therapies in oncology: Influence of treatment outcome description, elicitation technique and treatment experience on preferences

1987 • 140 citations

Quality-adjusted life-years. Ethical implications for physicians and policymakers

1990 • 134 citations

Introducing new treatments for cancer : practical, ethical and legal problems

1992 • 131 citations

Cancer Patients' Decision Making and Trial-entry Preferences

1995 • 120 citations

Eliciting Preferences for Alternative Cancer Drug Treatments

1985 • 83 citations

Cancer Patients' Evaluations of Their Current Health State

1992 • 63 citations

Using economic analysis to determine the resource consequences of choices made in planning clinical trials

1985 • 51 citations

Patients versus surrogates: whose opinion counts on ethics review panels?

1989 • 42 citations

When was a "negative" clinical trial big enough? How many patients you needed depends on what you found

1985 • 40 citations

Prescribing propensity

1994 • 38 citations

Risk language preferred by mothers in considering a hypothetical new vaccine for their children.

1992 • 16 citations