Mapping the Glycoprotein Ib-binding Site in the von Willebrand Factor A1 Domain

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Structural Basis of Collagen Recognition by Integrin α2β1

2000 • 945 citations

Specific Synergy of Multiple Substrate–Receptor Interactions in Platelet Thrombus Formation under Flow

1998 • 809 citations

A fast algorithm for rendering space-filling molecule pictures

1988 • 616 citations

Shear-dependent changes in the three-dimensional structure of human von Willebrand factor

1996 • 598 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Crystal Structure of the von Willebrand Factor A1 Domain and Implications for the Binding of Platelet Glycoprotein Ib

1998 • 255 citations

Selectin-mediated rolling of neutrophils on immobilized platelets

1993 • 236 citations

Structure of the von Willebrand factor domain interacting with glycoprotein Ib.

1988 • 208 citations

Substructure of human von Willebrand factor.

1985 • 198 citations

Localization and characterization of a heparin binding domain peptide of human von Willebrand factor.

1992 • 171 citations

Structure-function relationship of human von Willebrand factor

1987 • 164 citations

Platelet interaction with rabbit subendothelium in von Willebrand's disease: altered thrombus formation distinct from defective platelet adhesion.

1984 • 153 citations

Interaction of asialo von Willebrand factor with glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and mediates platelet aggregation.

1985 • 150 citations

Isolation of the von Willebrand Factor Domain Interacting with Platelet Glycoprotein Ib, Heparin, and Collagen and Characterization of Its Three Distinct Functional Sites

1989 • 147 citations

Identification of Amino Acid Residues Essential for von Willebrand Factor Binding to Platelet Glycoprotein Ib.

1995 • 143 citations

Structure-function relationship of human von Willebrand factor

1987 • 131 citations

The interaction of the von Willebrand factor-A1 domain with platelet glycoprotein Ib/IX. The role of glycosylation and disulfide bonding in a monomeric recombinant A1 domain protein.

1993 • 114 citations

Interaction of purified type IIB von Willebrand factor with the platelet membrane glycoprotein Ib induces fibrinogen binding to the glycoprotein IIb/IIIa complex and initiates aggregation.

1985 • 106 citations

Effect of deletion of the A1 domain of von Willebrand factor on its binding to heparin, collagen and platelets in the presence of ristocetin

1991 • 105 citations

Crystal structure of the von Willebrand factor A1 domain in complex with the function blocking NMC-4 Fab

1998 • 105 citations

Native conformation of human von Willebrand protein. Analysis by electron microscopy and quasi-elastic light scattering.

1985 • 102 citations

von Willebrand disease type B: a missense mutation selectively abolishes ristocetin-induced von Willebrand factor binding to platelet glycoprotein Ib.

1992 • 100 citations

Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli

1991 • 82 citations

Type 2M von Willebrand Disease: F606I and I662F Mutations in the Glycoprotein Ib Binding Domain Selectively Impair Ristocetin- but not Botrocetin-Mediated Binding of von Willebrand Factor to Platelets

1998 • 80 citations

EFFECT OF MULTIMERIZATION OF HUMAN AND RECOMBINANT VON WILLEBRAND FACTOR ON PLATELET AGGREGATION, BINDING TO COLLAGEN AND BINDING OF COAGULATION FACTOR VIII

1996 • 69 citations

Mapping the Collagen-binding Site in the I Domain of the Glycoprotein Ia/IIa (Integrin α2β1)

2000 • 52 citations

Production in Escherichia coli of a biologically active subfragment of von Willebrand factor corresponding to the platelet glycoprotein Ib, collagen and heparin binding domains

1989 • 35 citations

Independent assembly and secretion of a dimeric adhesive domain of von Willebrand factor containing the glycoprotein Ib-binding site

1991 • 31 citations

Analysis of the Structure and Function of the von Willebrand Factor A1 Domain Using Targeted Deletions and Alanine-Scanning Mutagenesis

1996 • 27 citations