Why we need easy access to all data from all clinical trials and how to accomplish it

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

2007 • 4,614 citations

Comparison of Upper Gastrointestinal Toxicity of Rofecoxib and Naproxen in Patients with Rheumatoid Arthritis

2000 • 4,048 citations

Selective Publication of Antidepressant Trials and Its Influence on Apparent Efficacy

2008 • 2,344 citations

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

2006 • 2,010 citations

Avoidable waste in the production and reporting of research evidence

2009 • 1,916 citations

Antidepressant Drug Effects and Depression Severity

2010 • 1,881 citations

Empirical Evidence for Selective Reporting of Outcomes in Randomized Trials

2004 • 1,728 citations

Risk of Cardiovascular Events Associated With Selective COX-2 Inhibitors

2001 • 1,716 citations

Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects

2014 • 1,463 citations

A Comparison of Results of Meta-analyses of Randomized Control Trials and Recommendations of Clinical Experts

1992 • 1,451 citations

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

2009 • 1,337 citations

Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study

2005 • 910 citations

The truth about the drug companies: how they deceive us and what to do about it

2005 • 903 citations

Publication bias in clinical trials due to statistical significance or direction of trial results

2009 • 846 citations

Rosiglitazone Evaluated for Cardiovascular Outcomes — An Interim Analysis

2007 • 762 citations

Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications

2003 • 640 citations

Failing the Public Health — Rofecoxib, Merck, and the FDA

2004 • 598 citations

Avoidable Waste in the Production and Reporting of Research Evidence

2009 • 576 citations

Effect of Muraglitazar on Death and Major Adverse Cardiovascular Events in Patients With Type 2 Diabetes Mellitus

2005 • 559 citations

Reboxetine for acute treatment of major depression: systematic review and meta-analysis of published and unpublished placebo and selective serotonin reuptake inhibitor controlled trials

2010 • 549 citations

Facemasks and Hand Hygiene to Prevent Influenza Transmission in Households

2009 • 534 citations

The Truth About Drug Companies: How They Deceive Us and What to Do About It.

2005 • 512 citations

Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health Research

2004 • 441 citations

Corporate Crime in the Pharmaceutical Industry

1984 • 403 citations

Empirical Study of Data Sharing by Authors Publishing in PLoS Journals

2009 • 380 citations

Outcome Reporting in Industry-Sponsored Trials of Gabapentin for Off-Label Use

2009 • 357 citations

Selling sickness: how the world's biggest pharmaceutical companies are turning us all into patients

2006 • 348 citations

A Survey of Clinical Trials of Antibiotic Prophylaxis in Colon Surgery: Evidence against Further Use of No-Treatment Controls

1981 • 345 citations

Methodology and overt and hidden bias in reports of 196 double-blind trials of nonsteroidal antiinflammatory drugs in rheumatoid arthritis

1989 • 344 citations

Reporting Bias in Drug Trials Submitted to the Food and Drug Administration: Review of Publication and Presentation

2008 • 323 citations

Promoting Access to Public Research Data for Scientific, Economic, and Social Development

2004 • 295 citations

Rational Diagnosis and Treatment

1986 • 251 citations

Factors Associated with Findings of Published Trials of Drug–Drug Comparisons: Why Some Statins Appear More Efficacious than Others

2007 • 247 citations

Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study

2005 • 243 citations

Global Corruption Report

2011 • 239 citations

Sharing research data to improve public health

2011 • 238 citations

What Went Wrong

2002 • 237 citations

Influences on the Quality of Published Drug Studies

1996 • 223 citations

On the Take: How Medicine’s Complicity with Big Business Can Endanger your Health

2008 • 219 citations

Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis

2006 • 217 citations

Comparison of protocols and registry entries to published reports for randomised controlled trials

2011 • 214 citations

A comparison of results of meta-analyses of randomized control trials and recommendations of clinical experts. Treatments for myocardial infarction

1992 • 206 citations

Powerful medicines: the benefits, risks, and costs of prescription drugs

2005 • 199 citations

Discrepancies in sample size calculations and data analyses reported in randomised trials: comparison of publications with protocols

2008 • 195 citations

Are research ethics committees behaving unethically? Some suggestions for improving performance and accountability

1996 • 187 citations

Drug-Review Deadlines and Safety Problems

2008 • 174 citations

Overtreated: why too much medicine is making us sicker and poorer

2008 • 172 citations

DESIGN AND REPORTING MODIFICATIONS IN INDUSTRY-SPONSORED COMPARATIVE PSYCHOPHARMACOLOGY TRIALS

2002 • 169 citations

Let Them Eat Prozac

2003 • 163 citations

Randomized controlled trials of aprotinin in cardiac surgery: could clinical equipoise have stopped the bleeding?

2005 • 158 citations

Selling Sickness: How the World's Biggest Pharmaceutical Companies Are Turning Us All Into Patients

2006 • 154 citations

Powerful Medicines: The Benefits, Risks, and Costs of Prescription Drugs

2005 • 149 citations

On the Take

2005 • 146 citations

Preparing raw clinical data for publication: guidance for journal editors, authors, and peer reviewers

2010 • 141 citations

A Systematic Examination of the Citation of Prior Research in Reports of Randomized, Controlled Trials

2011 • 141 citations

The $800 million pill: the truth behind the cost of new drugs

2005 • 140 citations

Overdosed America: The Broken Promise of American Medicine

2004 • 128 citations

Problems in the Design and Reporting of Trials of Antifungal Agents Encountered During Meta-analysis

1999 • 125 citations

Rosiglitazone: what went wrong?

2010 • 119 citations

Risk of Cardiovascular Events and Celecoxib: a Systematic Review and Meta-Analysis

2006 • 117 citations

The $800 Million Pill

2004 • 114 citations

Efficacy, safety, and cost of new anticancer drugs

2002 • 110 citations

Hooked: Ethics, the Medical Profession, and the Pharmaceutical Industry

2006 • 102 citations

Clinical trials and drug promotion: Selective reporting of study 329

2008 • 95 citations

Minimizing Bias in Randomized Trials

2010 • 94 citations

From Mexico to Mali: four years in the history of clinical trial registration

2009 • 83 citations

Rational Diagnosis and Treatment: Evidence-Based Clinical Decision-Making

1981 • 81 citations

Did regulators fail over selective serotonin reuptake inhibitors?

2006 • 78 citations

Why Patients Continue to Participate in Clinical Research

2008 • 74 citations

Science, politics and the pharmaceutical industry

1996 • 73 citations

The effect of lorcainide on arrhythmias and survival in patients with acute myocardial infarction: an example of publication bias

1993 • 72 citations

Globalized Clinical Trials and Informed Consent

2009 • 70 citations

Complications: tracking down the data on oseltamivir

2009 • 67 citations

Science, politics, and the pharmaceutical industry

1995 • 60 citations

FDA is incapable of protecting US “against another Vioxx”

2004 • 57 citations

Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer

2007 • 53 citations

The Truth about Drug Companies: How They Deceive Us and What to Do about It

2006 • 47 citations

Ensuring safe and effective drugs: who can do what it takes?

2011 • 44 citations

Setting the RECORD Straight

2010 • 43 citations

Overdo$ed America: The Broken Promise of American Medicine

2004 • 39 citations

Prescription for profit

1993 • 37 citations

Finding studies on reboxetine: a tale of hide and seek

2010 • 35 citations

Bias in double-blind trials.

1990 • 31 citations

Big publishers cut access to journals in poor countries

2011 • 31 citations

Side effects: a prosecutor, a whistleblower, and a bestselling antidepressant on trial

2008 • 26 citations

Evidence in Vioxx suits shows intervention by Merck officials.

2005 • 26 citations

Our Daily Meds

2008 • 21 citations

The Whistleblower: Confessions of a Healthcare Hitman

2006 • 19 citations

Hooked: Ethics, the Medical Profession, and the Pharmaceutical Industry

2008 • 14 citations

GlaxoSmithKline to set up comprehensive online clinical trials register

2004 • 14 citations

Denmark takes a lead on research ethics

1998 • 13 citations

[Constraints on publication rights in industry-initiated clinical trials--secondary publication].

2006 • 13 citations

Prescription for Profits : How the Pharmaceutical Industry Bankrolled the Unholy Marriage Between Science and Business

1997 • 11 citations

Big pharma and the UK Government

2006 • 7 citations

Book Review: Powerful medicines: the benefits, risks and costs of prescription drugs. Avorn J.

2005 • 7 citations

Pfizer pays record fine for off-label promotion of four drugs

2009 • 7 citations

Crisis deepens at the US Food and Drug Administration

2004 • 6 citations

In clear sight

2009 • 5 citations

Outcome reporting bias and individual patient data meta-analysis: a case study in surgery

2001 • 5 citations

George J. Annas

1974 • 2 citations

Survey of FDA Scientists Shows They Feel Pressure to Exclude or Alter Findings Fear Retaliation for Voicing Safety Concerns

2006 • 1 citations