In vitro studies of striatal vesicles containing the vesicular monoamine transporter (VMAT2): rat versus mouse differences in sequestration of 1-methyl-4-phenylpyridinium.

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

1984 • 1,092 citations

A cDNA that suppresses MPP+ toxicity encodes a vesicular amine transporter

1992 • 594 citations

VMAT2 knockout mice: Heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity

1997 • 420 citations

Energy-dependent uptake of N-methyl-4-phenylpyridinium, the neurotoxic metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, by mitochondria.

1986 • 404 citations

Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.

1989 • 248 citations

Studies on the Neurotoxicity of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine: Inhibition of NAD‐Linked Substrate Oxidation by Its Metabolite, 1‐Methyl‐4‐Phenylpyridinium

1986 • 241 citations

Increased MPTP Neurotoxicity in Vesicular Monoamine Transporter 2 Heterozygote Knockout Mice

1998 • 177 citations

Neurochemical and behavioral effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) in rat, guinea pig, and monkey.

1984 • 167 citations

A simple method for the determination of affinity and binding site concentration in receptor binding studies

1977 • 136 citations

Lobeline and nicotine evoke [3H]overflow from rat striatal slices preloaded with [3H]dopamine: differential inhibition of synaptosomal and vesicular [3H]dopamine uptake.

1997 • 132 citations

Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 1: Systemic administration.

1994 • 130 citations

Correlation between the neostriatal content of the 1-methyl-4-phenylpyridinium species and dopaminergic neurotoxicity following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration to several strains of mice.

1991 • 115 citations

Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.

1987 • 101 citations

Dihydrotetrabenazine Binding and Monoamine Uptake in Mouse Brain Regions

1986 • 100 citations

Studies on species sensitivity to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Part 2: Central administration of 1-methyl-4-phenylpyridinium.

1994 • 97 citations

Energy-driven uptake of the neurotoxin 1-methyl-4-phenylpyridinium into chromaffin granules via the catecholamine transporter.

1988 • 88 citations

Vesicular monoamine transporter-2: Immunogold localization in striatal axons and terminals

1997 • 87 citations

Inhibition of brain vesicular monoamine transporter (VMAT2) enhances 1-methyl-4-phenylpyridinium neurotoxicity in vivo in rat striata.

2000 • 86 citations

Dynamic Storage of Dopamine in Rat Brain Synaptic Vesicles In Vitro

1995 • 82 citations

Quantitative autoradiography of the dopamine uptake complex in rat brain using [3H]GBR 12935: binding characteristics

1991 • 80 citations

Comparison of characteristics of dopamine uptake and mazindol binding in mouse striatum

1989 • 69 citations

Selective MPP+ uptake into synaptic dopamine vesicles: possible involvement in MPTP neurotoxicity

1993 • 67 citations

The neurotoxin 1-methyl-4-phenylpyridinium is sequestered within neurons that contain the vesicular monoamine transporter

1998 • 58 citations

In Brown Norway Rats, MPP+ Is Accumulated in the Nigrostriatal Dopaminergic Terminals but It Is Not Neurotoxic: A Model of Natural Resistance to MPTP Toxicity

1994 • 48 citations

Striatal concentrations of vesicular monoamine transporters are identical in MPTP-sensitive (C57BL/6) and -insensitive (CD-1) mouse strains

1996 • 44 citations

Potentiation by reserpine and tetrabenazine of brain catecholamine depletions by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in the mouse; evidence for subcellular sequestration as basis for cellular resistance to the toxicant

1988 • 38 citations

Mechanisms of Toxicity and Cellular Resistance to 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and 1‐Methyl‐4‐Phenylpyridinium in Adrenomedullary Chromaffin Cell Cultures

1990 • 36 citations

Chloride ion increases [3H]dopamine accumulation by synaptic vesicles purified from rat striatum: inhibition by thiocyanate ion

1990 • 34 citations

Uptake of the Neurotoxin, 4-MethylphenylPyridinium, into Chromaffin Granules and Synaptic Vesicles: A Proton Gradient Drives Its Uptake through Monoamine Transporter

1993 • 32 citations

Nucleoside triphosphate and cation requirement for dopamine uptake by plain synaptic vesicles isolated from rat cerebrums

1976 • 28 citations

Characterization of binding of [3H]GBR 12935 (1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-piperazine) to membranes and to solubilized membrane extracts from terminal field regions of mesolimbic, mesocortical and nigrostriatal dopamine pathways

1990 • 16 citations

Distribution of [³H]Dihydrotetrabenazine Binding in Bovine Striatal Subsynaptic Fractions: Enrichment of Higher Affinity Binding in a Synaptic Vesicle Fraction

1988 • 16 citations

Differences in the reserpine-sensitive storage in vivo of 1-methyl-4-phenylpyridinium in rats and mice may explain differences in catecholamine toxicity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1994 • 13 citations