The Human Platelet

The Integrative Action of the Nervous System.

1907 • 4,174 citations

The Biochemical Basis of Neuropharmacology.

1974 • 1,911 citations

"Serotonin Depression"—A Biochemical Subgroup Within the Affective Disorders?

1976 • 670 citations

THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE

1914 • 604 citations

Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children

1961 • 567 citations

5-Hydroxytryptamine in the Hind-Brain of Depressive Suicides

1967 • 424 citations

Blood platelets as a model for monoamine-containing neurones

1973 • 407 citations

5-HYDROXYINDOLE COMPOUNDS IN THE CEREBROSPINAL FLUID OF PATIENTS WITH PSYCHIATRIC OR NEUROLOGICAL DISEASES

1966 • 375 citations

Reduced Monoamine Oxidase Activity in Blood Platelets from Schizophrenic Patients

1972 • 358 citations

Reduced Monoamine Oxidase Activity in Blood Platelets from Bipolar Depressed Patients

1972 • 335 citations

Abnormalities of Indoleamines in Affective Disorders

1972 • 307 citations

NORADRENALINE, 5-HYDROXYTRYPTAMINE, AND 5-HYDROXYINDOLEACETIC ACID IN HINDBRAINS OF SUICIDAL PATIENTS

1968 • 304 citations

Reduced Monoamine Oxidase Activity in Platelets: A Possible Genetic Marker for Vulnerability to Schizophrenia

1973 • 300 citations

Biochemical Investigations in Headache: Increase in the Hydroxyindoleacetic Acid Excretion During Migraine Attacks

1961 • 291 citations

Plasma Serotonin in Migraine and Stress

1967 • 278 citations

5-HYDROXYTRYPTAMINE, NORADRENALINE, AND DOPAMINE IN BRAINSTEM, HYPOTHALAMUS, AND CAUDATE NUCLEUS OF CONTROLS AND OF PATIENTS COMMITTING SUICIDE BY COAL-GAS POISONING

1969 • 259 citations

Decreased uptake of 5-hydroxytryptamine in blood platelets from depressed patients

1976 • 251 citations

TOTAL PLASMA SEROTONIN, 5-HYDROXYINDOLEACETIC ACID AND p-HYDROXY-m-METHOXYMANDELIC ACID EXCRETION IN NORMAL AND MIGRAINOUS SUBJECTS

1965 • 251 citations

Increased Blood Serotonin and Platelets in Early Infantile Autism

1970 • 248 citations

The effects of high phenylalanine concentrations on serotinin and catecholamine metabolism in the human brain

1972 • 223 citations

ACID MONOAMINE METABOLITES OF CEREBROSPINAL FLUID IN MENTAL DEPRESSION AND MANIA

1966 • 215 citations

Serotonin and 5-hydroxyindoleacetic acid in discrete areas of the brainstem of suicide victims and control patients.

1974 • 206 citations

Homovanillic and 5-Hydroxyindoleacetic Acid in Cerebrospinal Fluid of Depressed Patients

1971 • 177 citations

Cerebral Monoamines and Depression

1973 • 175 citations

Parkinson's disease: from brain homogenate to treatment.

1973 • 175 citations

Monoamine oxidase in schizophrenia and other behavioral disorders

1974 • 164 citations

5-HYDROXYTRYPTAMINE DEFICIENCY IN PHENYLKETONURIA

1957 • 157 citations

Sodium‐dependent accumulation of 5‐hydroxytryptamine by rat blood platelets

1969 • 145 citations

Isolated 5‐hydroxytryptamine organelles of rabbit blood platelets: physiological properties and drug‐induced changes

1968 • 134 citations

Biogenic Amines in Autistic and Atypical Children

1974 • 132 citations

Average evoked response in bipolar and unipolar affective disorders: relationship to sex, age of onset, and monoamine oxidase.

1973 • 129 citations

Uptake and efflux of ¹⁴ C‐dopamine in platelets

1975 • 107 citations

The Possible Relationship of Serotonin to the Migraine Syndrome

1969 • 105 citations

Serotonin concentrations in whole blood of hyperactive children

1971 • 98 citations

Subcellular Localization of 5-Hydroxytryptamine and Histamine in Blood Platelets

1967 • 97 citations

REVERSAL OF HYPOTONIA IN INFANTS WITH DOWN'S SYNDROME BY ADMINISTRATION OF 5-HYDROXYTRYPTOPHAN

1967 • 95 citations

BLOOD-SEROTONIN ACTIVITY IN TRISOMIC AND TRANSLOCATION DOWN'S SYNDROME

1965 • 89 citations

BLOOD-SEROTONIN DEFICIENCY IN DOWN'S SYNDROME

1965 • 89 citations

Blood platelet monoamine oxidase activity in psychiatric patients.

1974 • 88 citations

Laboratory predictions of infantile autism based on 5-hydroxytryptamine efflux from blood platelets and their correlation with the rimland E-2 score

1971 • 86 citations

New aspects on the storage of 5-hydroxytryptamine in blood platelets

1971 • 85 citations

Abnormalities of 5‐hydroxytryptamine uptake and binding by blood platelets from children with Down's syndrome

1971 • 83 citations

Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with <scp>l</scp>‐DOPA

1970 • 82 citations

Platelet monoamine oxidase activity and substrate preferences in schizophrenic patients.

1974 • 81 citations

Effects of tricyclic antidepressants upon human platelet monoamine oxidase

1974 • 81 citations

Abnormalities in Platelet 5-Hydroxytryptamine Efflux in Patients with Infantile Autism

1970 • 81 citations

Mechanism and Control of Initiation in the Translation of R17 RNA

1972 • 75 citations

Multiple Forms of Brain Monoamine Oxidase in Schizophrenic and Normal Individuals

1974 • 73 citations

The Relationship between Decreased 5-Hydroxyindole Metabolism and Mental Defect in Phenylketonuria

1959 • 73 citations

Elevated blood serotonin concentrations in unmediated chronic schizophrenic patients: a preliminary study

1975 • 69 citations

Neurochemistry of Parkinsonism

1972 • 65 citations

5-HYDROXYINDOLES IN MENTAL DEFICIENCY

1960 • 64 citations

Comparison of monoamine oxidase substrate activities in twins, schizophrenics, depressives, and controls.

1974 • 63 citations

Monoamine oxidase activity in brains from schizophrenic and mentally normal individuals

1974 • 62 citations

Depressed 5-Hydroxyindole Levels Associated With Hyperactive and Aggressive Behavior

1976 • 62 citations

Platelet‐bound and free serotonin levels in jugular and forearm venous blood during migraine

1976 • 59 citations

Platelet monoamine oxidase in schizophrenics

1975 • 59 citations

Serotonin in Down's Syndrome

1975 • 59 citations

The Abnormality of Tryptophane Metabolism in Children with Mongolism

1962 • 58 citations

Increased human platelet monoamine oxidase activity during lithium carbonate therapy

1974 • 58 citations

MOLECULAR ABERRATION IN PLATELET MONOAMINE OXIDASE IN SCHIZOPHRENIA

1975 • 58 citations

Blood Serotonin Levels in Severe Mental Retardation

1973 • 58 citations

PLASMA UPTAKE OF DOPAMINE AND 5-HYDROXYTRYPTAMINE AND PLASMA-CATECHOLAMINE LEVELS IN PATIENTS WITH HUNTINGTON'S CHOREA

1974 • 58 citations

Differential uptake of biogenic amines by isolated 5-hydroxytryptamine organelles of blood platelets

1969 • 54 citations

Platelet adenylate cyclase responses in depression: Implications for a receptor defect

1974 • 49 citations

Serotonin and Platelet Function in Duchenne Muscular Dystrophy

1973 • 48 citations

Down's Syndrome: Transport, Storage, and Metabolism of Serotonin in Blood Platelets

1972 • 47 citations

Platelet monoamine oxidase activity in children and adolescents

1976 • 46 citations

Platelet Serotonin of Hyperactive School Age Boys

1974 • 45 citations

On the Mechanism of the Brain Serotonin Depletion in Experimental Phenylketonuria

1965 • 44 citations

Imipramine and Lithium Effects on Biogenic Amine Transport in Depressed and Manic-Depressed Patients

1970 • 43 citations

Relationship between internal Na⁺/K⁺ and the accumulation of ¹⁴C‐5‐hydroxytryptamine by rat platelets

1971 • 42 citations

L-tryptophan metabolism in phenylketonuria

1966 • 42 citations

5‐Hydroxyindole Levels in the Blood and CSF in Down's Syndrome, Phenylketonuria and Severe Mental Retardation

1972 • 38 citations

Monoamine oxidase activity of blood platelets and their ability to store 5-hydroxytryptamine in some mental deficiencies

1964 • 35 citations

A case of histidinemia controlled with a low histidine diet.

1968 • 35 citations

Diminished activity of platelet monoamine oxidase in Down's syndrome.

1971 • 32 citations

Decreased ATPase and Increased Sodium Content of Platelets in Down's Syndrome

1974 • 32 citations

PLATELET-SEROTONIN LEVEL IN CHILDREN WITH " MINIMAL BRAIN DYSFUNCTION "

1969 • 31 citations

Storage of ATP and 5‐hydroxytryptamine in blood platelets of guinea‐pigs

1971 • 31 citations

Some structural requirements for inhibition of type A and B forms of rabbit monoamine oxidase by tricyclic psychoactive drugs.

1975 • 29 citations

Inhibition of lung, liver and brain monoamine oxidase by imipramine and desipramine

1974 • 27 citations

Depressed Whole Blood Serotonin Levels Associated With Behavioral Abnormalities in the de Lange Syndrome

1973 • 26 citations

The metabolism of 5-hydroxytryptamine (serotonin) in the newborn

1965 • 26 citations

THE LEVEL AND DIURNAL RHYTHM OF SERUM SEROTONIN IN MANIC-DEPPESSIVE PATIENTS

1968 • 25 citations

Different localization of reserpine and tyramine within the 5-hydroxytryptamine organelles of blood platelets

1969 • 24 citations

Biological studies in childhood schizophrenia: serotonin uptake by platelets.

1971 • 21 citations

GENERAL METABOLIC STUDIES ON SCHIZOPHRENIC CHILDREN *

1962 • 21 citations

THE CONCENTRATION OF SEROTONIN BY PLATELETS IN DOWN'S SYNDROME

1968 • 21 citations

Down's syndrome

1972 • 21 citations

Platelet monoamine oxidase in children with infantile autism.

1975 • 19 citations

The inactivation of 5-hydroxytryptamine by blood platelets in mental deficiency with elevated serum 5-hydroxytryptamine

1962 • 18 citations

Uptake and loss of14C-dopamine by platelets from children with infantile autism

1972 • 14 citations

PLATELET‐RICH PLASMA 5‐HYDROXYTRYPTAMINE, URINARY 5‐HYDROXYINDOLEACETIC ACID AND TRYPTOPHAN INGESTION IN MONGOLS

1971 • 13 citations

BLOOD-SEROTONIN IN DOWN'S SYNDROME

1967 • 11 citations

5-Hydroxyindoles and Migraine

1968 • 11 citations

AMINE-OXIDASE INHIBITORS AS POSSIBLE TREATMENT FOR PHENYLKETONURIA

1961 • 11 citations

SEROTONIN LEVELS IN INFANT HYPOTHYROIDISM

1970 • 10 citations

[Study of the urinary excretion of some tryptophan metabolites in mongoloid children].

1960 • 10 citations

Defective binding of 5-HT by blood platelets from children with the trisomy 21 form of Down's syndrome.

1969 • 8 citations

Shadow of the head of Comet Kohoutek

1975 • 6 citations

Plasma Serotonin Levels in Migraine

1968 • 6 citations

Deleted Work

1955 • 0 citations