Apoptosis in Vascular Endothelial Cells Caused by Serum Deprivation, Oxidative Stress and Transforming Growth Factor-β

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

The American Journal of Physiology

1899 • 5,863 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Oxidative stress as a mediator of apoptosis

1994 • 2,210 citations

The extracellular matrix as a cell survival factor.

1993 • 1,541 citations

Hypertension: Pathophysiology, Diagnosis, and Management

1991 • 940 citations

Programmed cell death and Bcl-2 protection in very low oxygen

1995 • 638 citations

Prevention of hypoxia-induced cell death by Bcl-2 and Bcl-xL

1995 • 611 citations

In situ end‐labelling detects DNA strand breaks in apoptosis and other physiological and pathological states

1993 • 584 citations

Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells.

1994 • 504 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Chapter 1 Anatomical Methods in Cell Death

1995 • 475 citations

Patterns of cell death.

1988 • 470 citations

Cardiac Allograft Vasculopathy

1997 • 439 citations

Free radicals in biology and medicine

1985 • 416 citations

Transforming growth factor-beta: a general review.

1996 • 400 citations

Tumor necrosis factor induces apoptosis (programmed cell death) in normal endothelial cells in vitro.

1991 • 358 citations

High-Glucose–Triggered Apoptosis in Cultured Endothelial Cells

1995 • 342 citations

Cell death by apoptosis during involution of the lactating breast in mice and rats

1989 • 341 citations

Growth Factors and Mitogen-Activated Protein Kinases

1998 • 329 citations

Induction of Endothelial Cell Apoptosis by TNFα: Modulation by Inhibitors of Protein Synthesis

1994 • 292 citations

Reactive oxygen species and the regulation of cell death by the Bcl-2 gene family

1995 • 279 citations

Apoptosis of vascular endothelial cells by fibroblast growth factor deprivation

1990 • 230 citations

Microvascular rarefaction and tissue vascular resistance in hypertension

1989 • 230 citations

Laboratory investigation

2005 • 176 citations

Identification of the Snake Venom Substance That Induces Apoptosis

1996 • 172 citations

Cell death and cell proliferation during atrophy of the rat parotid gland induced by duct obstruction

1987 • 147 citations

Bcl-2 and the ICE family of apoptotic regulators: making a connection

1997 • 147 citations

Mechanism of deletion of endothelial cells during regression of the corpus luteum.

1984 • 143 citations

Radiation-induced apoptosis in microvascular endothelial cells

1997 • 143 citations

Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.

1995 • 142 citations

Vascular remodeling in primary pulmonary hypertension. Potential role for transforming growth factor-beta.

1994 • 142 citations

Cyclic angiogenesis and blood vessel regression in the ovary: blood vessel regression during luteolysis involves endothelial cell detachment and vessel occlusion.

1996 • 136 citations

MECHANISMS OF ENDOTHELIAL CELL INJURY IN ACUTE INFLAMMATION

1994 • 136 citations

The Microcirculation and Hypertension

2012 • 130 citations

Microvascular rarefaction in spontaneously hypertensive rat cremaster muscle

1981 • 123 citations

Role of protein kinase C in the inhibition by fibroblast growth factor of apoptosis in serum-depleted endothelial cells

1990 • 119 citations

Cellular events in experimental unilateral ischemic renal atrophy and in regeneration after contralateral nephrectomy.

1990 • 114 citations

Plasma from patients with idiopathic and human immunodeficiency virus- associated thrombotic thrombocytopenic purpura induces apoptosis in microvascular endothelial cells

1996 • 111 citations

Capillary rarefaction characteristic of the skeletal muscle of hypertensive patients

1988 • 104 citations

Rapid Microvessel Rarefaction With Elevated Salt Intake and Reduced Renal Mass Hypertension in Rats

1996 • 102 citations

Capillary rarefaction in the forearm skin in essential hypertension

1995 • 101 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Inhibits Anchorage-Disruption-Induced Apoptosis in Microvessel Endothelial Cells by Inducing Scaffold Formation

1997 • 98 citations

Nitric oxide donors induce apoptosis in glomerular mesangial cells, epithelial cells and endothelial cells

1996 • 96 citations

Evidence that tumor necrosis factor triggers apoptosis in human endothelial cells by interleukin-1-converting enzyme-like protease-dependent and -independent pathways.

1997 • 92 citations

Localization of vascular resistance changes during hypertension.

1986 • 92 citations

Extracellular ATP and adenosine cause apoptosis of pulmonary artery endothelial cells

1997 • 91 citations

Apoptosis Occurs in Endothelial Cells during Hypertension-Induced Microvascular Rarefaction

1997 • 90 citations

Transforming growth factor beta1 induces angiogenesis in vivo with a threshold pattern.

1996 • 85 citations

Induction of Apoptosis by Hemorrhagic Snake Venom in Vascular Endothelial Cells

1993 • 85 citations

Nailfold microcirculation in normotensive and essential hypertensive subjects, as assessed by video-microscopy

1992 • 83 citations

The microcirculation and hypertension

1992 • 79 citations

Exposure to low concentrations of hydrogen peroxide causes delayed endothelial cell death and inhibits proliferation of surviving cells

1995 • 77 citations

Induction of human endothelial cell apoptosis requires both heat shock and oxidative stress responses

1997 • 72 citations

Rarefication of the arterioles and capillary network in the brain of rats with different forms of hypertension

1985 • 70 citations

Death from inside out: an overview

1994 • 69 citations

Cytokines and growth factors in endothelial dysfunction

1993 • 68 citations

Penetration of the systemic blood pressure into the microvasculature of rat skeletal muscle

1991 • 65 citations

Purification of a Vascular Apoptosis-Inducing Factor from Hemorrhagic Snake Venom

1997 • 60 citations

Comparison of gene expression in bovine aortic endothelium in vivo versus in vitro. Differences in growth regulatory molecules.

1993 • 52 citations

Microvascular alterations in the one-kidney, one-clip renal hypertensive rat

1984 • 49 citations

Expression of transforming growth factor-beta mRNAs and proteins in pulmonary vascular remodeling in the sheep air embolization model of pulmonary hypertension.

1994 • 47 citations

Clusterin expression and apoptosis in tissue remodeling associated with renal regeneration

1995 • 45 citations

Capillary growth and geometry during long-term hypertension and myocardial hypertrophy in dogs

1991 • 35 citations

Hypertension and the microcirculation: a brief overview of experimental studies

1992 • 34 citations

Pressure-independent arteriolar rarefaction in hypertension

1991 • 30 citations

Rabbit Aortic Endothelial Cell Hypoxia Induces Secretion of Transforming Growth Factor Beta and Augments Macrophage Adhesion In Vitro

1991 • 27 citations

Transforming growth factor-? proliferated vascular smooth muscle cells from spontaneously hypertensive rats

1995 • 16 citations

Endothelial cells protect vascular smooth muscle cells from H2O2 attack

1997 • 12 citations

Acute effects of pressure on resistance vessel geometry

1978 • 10 citations

Relationship Between the Early Arterial Reaction to Hypertension and the Development of Intimal Proliferation

1986 • 6 citations

DEVELOPMENTALLY REGULATED TRANSFORMING GROWTH FACTOR‐β1 ACTION ON VASCULAR SMOOTH MUSCLE GROWTH IN THE SHR

1994 • 6 citations