Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Regulation of the mevalonate pathway

1990 • 5,282 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

1994 • 994 citations

Liver regeneration: molecular mechanisms of growth control

1990 • 922 citations

SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

1993 • 906 citations

Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

1989 • 455 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

1993 • 396 citations

Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration

1991 • 374 citations

Independent regulation of sterol regulatory element-binding proteins 1 and 2 in hamster liver.

1995 • 305 citations

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. II. Purification and characterization

1993 • 300 citations

Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay

1991 • 293 citations

Importance of growth hormone for the induction of hepatic low density lipoprotein receptors.

1992 • 275 citations

Sterol-dependent repression of low density lipoprotein receptor promoter mediated by 16-base pair sequence adjacent to binding site for transcription factor Sp1.

1988 • 271 citations

Hepatocyte growth factor inhibits growth of hepatocellular carcinoma cells.

1992 • 256 citations

Identification of nucleotides responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene.

1990 • 236 citations

In vivo response of hepatocytes to growth factors requires an initial priming stimulus

1994 • 222 citations

42 bp element from LDL receptor gene confers end-product repression by sterols when inserted into viral TK promoter

1987 • 220 citations

Hepatocyte growth factor/scatter factor stimulates the Ras-guanine nucleotide exchanger

1993 • 206 citations

Increased mRNA for low density lipoprotein receptor in livers of rabbits treated with 17 alpha-ethinyl estradiol.

1986 • 196 citations

Three direct repeats and a TATA-like sequence are required for regulated expression of the human low density lipoprotein receptor gene.

1987 • 180 citations

A novel recognition motif for phosphatidylinositol 3-kinase binding mediates its association with the hepatocyte growth factor/scatter factor receptor.

1993 • 173 citations

Cytokine regulation of low density lipoprotein receptor gene transcription in HepG2 cells

1993 • 151 citations

Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.

1991 • 150 citations

In Vivo Stimulation of Low-Density Lipoprotein Degradation by Insulin

1984 • 121 citations

Hormonal regulation of low‐density lipoprotein (LDL) receptor activity in human hepatoma Hep G2 cells

1988 • 95 citations

Oncostatin M up-regulates low density lipoprotein receptors in HepG2 cells by a novel mechanism.

1991 • 88 citations

Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line Hep G2

1987 • 76 citations

Stimulation of rat hepatic low density lipoprotein receptors by glucagon. Evidence of a novel regulatory mechanism in vivo.

1993 • 73 citations

A Regulatory Element in the ApoCIII Promoter That Directs Hepatic Specific Transcription Binds to Proteins in Expressing and Nonexpressing Cell Types

1989 • 63 citations

Regulation of low-density-lipoprotein-receptro mRNA by insulin in human hepatoma Hep G2 cells

1989 • 59 citations

Macrophage-derived factors increase low density lipoprotein uptake and receptor number in cultured human liver cells.

1991 • 59 citations

Loss of resistance to dietary cholesterol in the rat after hypophysectomy: importance of the presence of growth hormone for hepatic low density lipoprotein-receptor expression.

1993 • 56 citations

Alteration in liver lipid and lipid fatty acid composition after partial hepatectomy in the rat

1968 • 55 citations

A Novel Recognition Motif for Phosphatidylinositol 3-Kinase Binding Mediates Its Association with the Hepatocyte Growth Factor/Scatter Factor Receptor

1993 • 49 citations

Regulation of Low Density Lipoprotein Receptor Gene Expression in Human Lymphocytes

1989 • 47 citations

Mitogenic stimulation alters the regulation of LDL receptor gene expression in human lymphocytes.

1990 • 41 citations

Hepatocyte growth factor: another ubiquitous cytokine

1993 • 39 citations

Lipid Distribution in Rat Liver After Partial Hepatectomy

1939 • 29 citations

Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells

1991 • 26 citations

Early induction of LDL receptor gene during rat liver regeneration

1993 • 22 citations

Ketoconazole and 25-hydroxycholesterol produce reciprocal changes in the rate of transcription of the human LDL receptor gene

1994 • 19 citations

Stimulation of LDL receptor activity in Hep-G2 cells by a serum factor(s)

1988 • 18 citations

Stimulation of low-density lipoprotein uptake in HepG2 cells by epidermal growth factor via a tyrosine kinase-dependent, but protein kinase C-independent, mechanism

1994 • 13 citations

Protein binding to the low density lipoprotein receptor promoter in vivo is differentially affected by gene activation in primary human cells.

1995 • 11 citations

Growth hormone and low-density lipoproteins.

1993 • 10 citations