The Thiazide-Sensitive Na-Cl Cotransporter and Human Disease

The sixth report of the Joint National Committee on prevention, detection, evaluation, and treatment of high blood pressure

1997 • 5,689 citations

Intracellular Functions of N-Linked Glycans

2001 • 2,334 citations

Human Hypertension Caused by Mutations in WNK Kinases

2001 • 1,427 citations

Gitelman's variant of Barter's syndrome, inherited hypokalaemic alkalosis, is caused by mutations in the thiazide-sensitive Na–Cl cotransporter

1996 • 1,167 citations

A Comparison of the Effects of Hydrochlorothiazide and Captopril on Glucose and Lipid Metabolism in Patients with Hypertension

1989 • 870 citations

WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II

2000 • 503 citations

Nephrogenic Diabetes Insipidus

2001 • 432 citations

Primary structure and functional expression of a cDNA encoding the thiazide-sensitive, electroneutral sodium-chloride cotransporter.

1993 • 370 citations

Gitelman's syndrome revisited: An evaluation of symptoms and health-related quality of life

2001 • 303 citations

Phenotype Resembling Gitelman's Syndrome in Mice Lacking the Apical Na+-Cl− Cotransporter of the Distal Convoluted Tubule

1998 • 291 citations

Pseudohypoaldosteronism Type II: Marked Sensitivity to Thiazides, Hypercalciuria, Normomagnesemia, and Low Bone Mineral Density

2002 • 218 citations

Mutations in the Na-Cl Cotransporter Reduce Blood Pressure in Humans

2001 • 168 citations

Novel mutations in the thiazide-sensitive NaCl cotransporter gene in patients with Gitelman syndrome with predominant localization to the C-terminal domain

1998 • 156 citations

Folding of Secretory and Membrane Proteins

1998 • 143 citations

Defective processing and expression of thiazide-sensitive Na-Cl cotransporter as a cause of Gitelman’s syndrome

1999 • 143 citations

Functional Expression of Mutations in the Human NaCl Cotransporter

2002 • 142 citations

N-Glycosylation at Two Sites Critically Alters Thiazide Binding and Activity of the Rat Thiazide-sensitive Na+

2003 • 107 citations

The Electroneutral Cation–Chloride Cotransporters

1998 • 99 citations

Genetic Variants of Thiazide-Sensitive NaCl-Cotransporter in Gitelman’s Syndrome and Primary Hypertension

2000 • 85 citations

Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families

1996 • 64 citations

Association of a mutation in thiazide-sensitive Na-Cl cotransporter with familial Gitelman's syndrome.

1996 • 59 citations

Gitelman's syndrome (Bartter's variant) maps to the thiazide-sensitive cotransporter gene locus on chromosome 16q13 in a large kindred.

1996 • 58 citations

Effect of ions on binding of the thiazide-type diuretic metolazone to kidney membrane

1990 • 48 citations

Potassium Channel Opening Properties of Thiazide Diuretics in Isolated Guinea Pig Resistance Arteries

1994 • 37 citations

Identification of a Gene Locus for Senior-Løken Syndrome in the Region of the Nephronophthisis Type 3 Gene

2002 • 35 citations

A Novel Natural Product Compound Enhances cAMP-Regulated Chloride Conductance of Cells Expressing CFTRΔF508

2002 • 32 citations

Manipulating the Folding Pathway of ΔF508 CFTR Using Chemical Chaperones

2003 • 15 citations