Paroxysmal nocturnal hemoglobinuria

Isolation of a human erythrocyte membrane glycoprotein with decay-accelerating activity for C3 convertases of the complement system.

1982 • 603 citations

Inhibition of complement activation on the surface of cells after incorporation of decay-accelerating factor (DAF) into their membranes.

1984 • 571 citations

Affected erythrocytes of patients with paroxysmal nocturnal hemoglobinuria are deficient in the complement regulatory protein, decay accelerating factor.

1983 • 438 citations

Release of decay-accelerating factor (DAF) from the cell membrane by phosphatidylinositol-specific phospholipase C (PIPLC). Selective modification of a complement regulatory protein.

1986 • 358 citations

Increased Susceptibility to Infection Associated with Abnormalities of Complement-Mediated Functions and of the Third Component of Complement (C3)

1970 • 316 citations

Two Anticomplementary Factors in Cobra Venom: Hemolysis of Guinea Pig Erythrocytes by One of Them

1969 • 301 citations

Immune lysis of normal human and paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. I. The sensitivity of PNH red cells to lysis by complement and specific antibody.

1966 • 291 citations

Paroxysmal Nocturnal Hemoglobinuria: Evidence for Monoclonal Origin of Abnormal Red Cells

1970 • 289 citations

7 Paroxysmal nocturnal haemoglobinuria

1989 • 246 citations

Homologous species restriction in lysis of human erythrocytes: a membrane-derived protein with C8-binding capacity functions as an inhibitor.

1986 • 241 citations

Hereditary Erythroblastic Multinuclearity Associated with a Positive Acidified‐Serum Test: a Type of Congenital Dyserythropoietic Anaemia

1969 • 217 citations

STUDIES ON DESTRUCTION OF RED BLOOD CELLS. II. CHRONIC HEMOLYTIC ANEMIA WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: CERTAIN IMMUNOLOGICAL ASPECTS OF THE HEMOLYTIC MECHANISM WITH SPECIAL REFERENCE TO SERUM COMPLEMENT 1

1939 • 217 citations

A platelet and granulocyte membrane defect in paroxysmal nocturnal hemoglobinuria: usefulness for the detection of platelet antibodies

1969 • 210 citations

The Aplastic Anaemia–Paroxysmal Nocturnal Haemoglobinuria Syndrome

1967 • 191 citations

Chronic Hemolytic Anemia with Paroxysmal Nocturnal Hemoglobinuria

1937 • 187 citations

LYSIS OF ERYTHROCYTES BY COMPLEMENT IN THE ABSENCE OF ANTIBODY

1970 • 181 citations

The Sugar-Water Test for Paroxysmal Nocturnal Hemoglobinuria

1966 • 163 citations

Properties of highly purified human properdin.

1968 • 158 citations

Deficiency of the Complement Regulatory Protein, Decay-Accelerating Factor, on Membranes of Granulocytes, Monocytes, and Platelets in Paroxysmal Nocturnal Hemoglobinuria

1985 • 153 citations

Studies in vivo and in vitro on an abnormality in the metabolism of C3 in a patient with increased susceptibility to infection

1970 • 143 citations

Paroxysmal nocturnal haemoglobinuria: clinical manifestations, haematology, and nature of the disease.

1972 • 131 citations

Homologous species restriction in lysis of erythrocytes by terminal complement proteins.

1981 • 129 citations

Deficiency of lymphocyte function-associated antigen 3 (LFA-3) in paroxysmal nocturnal hemoglobinuria. Functional correlates and evidence for a phosphatidylinositol membrane anchor.

1987 • 128 citations

THE PROPERDIN SYSTEM AND IMMUNITY. IV. THE HEMOLYSIS OF ERYTHROCYTES FROM PATIENTS WITH PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1

1956 • 116 citations

Paroxysmal nocturnal hemoglobinuria type III. Lack of an erythrocyte membrane protein restricting the lysis by C5b-9.

1987 • 113 citations

Isolation and properties of a glycine-rich β-glycoprotein of human serum

1970 • 107 citations

Variations in the Red Cells in Paroxysmal Nocturnal Haemoglobinuria

1973 • 105 citations

BLOOD COAGULATION INITIATION BY A COMPLEMENT-MEDIATED PATHWAY

1971 • 103 citations

Membrane factors responsible for homologous species restriction of complement-mediated lysis: evidence for a factor other than DAF operating at the stage of C8 and C9.

1986 • 94 citations

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA: CLINICAL AND LABORATORY STUDIES RELATING TO IRON METABOLISM AND THERAPY WITH ANDROGEN AND IRON

1966 • 87 citations

PASSIVE HEMOLYSIS BY SERUM AND COBRA VENOM FACTOR: A NEW MECHANISM INDUCING MEMBRANE DAMAGE BY COMPLEMENT

1969 • 80 citations

Normal polymorphic variations and transcription of the decay accelerating factor gene in paroxysmal nocturnal hemoglobinuria cells.

1988 • 80 citations

Neutrophil (Leucocyte) Alkaline Phosphatase in Paroxysmal Nocturnal Haemoglobinuria

1965 • 79 citations

Decreased number of circulating BFU-Es in paroxysmal nocturnal hemoglobinuria

1982 • 78 citations

Mechanisms of Immune Lysis of Red Blood Cells In Vitro I. PAROXYSMAL NOCTURNAL HEMOGLOBINURIA CELLS

1973 • 74 citations

Mechanism of complement-mediated activation of human blood platelets in vitro: comparison of normal and paroxysmal nocturnal hemoglobinuria platelets.

1977 • 74 citations

Thrombolytic Therapy for Inferior Vena Cava Thrombosis in Paroxysmal Nocturnal Hemoglobinuria

1985 • 72 citations

Glycolipid anchors are attached to Thy-1 glycoprotein rapidly after translation

1987 • 71 citations

The acetylcholinesterase defect in paroxysmal nocturnal hemoglobinuria: evidence that the enzyme is absent from the cell membrane

1985 • 71 citations

PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

1950 • 70 citations

Treatment of paroxysmal nocturnal hemoglobinuria

1982 • 70 citations

The Population of Cells in Paroxysmal Nocturnal Haemoglobinuria of Intermediate Sensitivity to Complement Lysis: Significance and Mechanism of Increased Immune Lysis

1974 • 69 citations

Historical Review: Paroxysmal Nocturnal Hemoglobinuria

1951 • 66 citations

Increased enzymatic activity of the alternative pathway convertase when bound to the erythrocytes of paroxysmal nocturnal hemoglobinuria.

1982 • 64 citations

Complement Lysis of Human Erythrocytes

1979 • 64 citations

Paroxysmal Nocturnal Hemoglobinuria Terminating in Acute Myeloblastic Leukemia

1969 • 62 citations

Increased Sensitivity to Complement of Erythroid and Myeloid Progenitors in Paroxysmal Nocturnal Hemoglobinuria

1983 • 62 citations

Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

1988 • 62 citations

Erythrocyte Acetylcholinesterase Deficiency in Paroxysmal Nocturnal Hemoglobinuria (PNH)—A Comparison of the Complement-Sensitive and Insensitive Populations

1969 • 57 citations

Acute myeloblastic leukemia in paroxysmal nocturnal hemoglobinuria. Evidence of evolution from the abnormal paroxysmal nocturnal hemoglobinuria clone.

1987 • 57 citations

Two populations of granulocytes in paroxysmal nocturnal hemoglobinuria

1979 • 54 citations

Decay-accelerating factor is present on paroxysmal nocturnal hemoglobinuria erythroid progenitors and lost during erythropoiesis in vitro.

1985 • 53 citations

Complement utilization by guinea pig 1 and 2-immunoglobulins through the C3 activator system.

1971 • 52 citations

The biologic activities of guinea pig antibodies. I. Separation of gamma1 and gamma2 immunoglobulins and their participation in allergic reactions of the immediate type.

1970 • 52 citations

Paroxysmal Nocturnal Haemoglobinuria in Thailand with Special Reference to an Association with Aplastic Anaemia

1978 • 52 citations

Urokinase treatment of Budd-Chiari syndrome

1983 • 52 citations

Long-Term Survival After Marrow Transplantation for Paroxysmal Nocturnal Hemoglobinuria with Aplastic Anemia

1984 • 48 citations

Paroxysmal nocturnal hemoglobinuria. Enhanced stimulation of platelets by the terminal complement components is related to the lack of C8bp in the membrane.

1988 • 44 citations

Association of Paroxysmal Nocturnal Hemoglobinuria with Erythroleukemia

1970 • 44 citations

Complement sensitivity of paroxysmal nocturnal hemoglobinuria bone marrow cells

1980 • 43 citations

The Initiation and Enhancement of Human Red Cell Lysis by Activators of the First Component of Complement and by First Component Esterase; Studies Using Normal Red Cells and Red Cells from Patients with Paroxysmal Nocturnal Hemoglobinuria*

1965 • 41 citations

THE BUDD‐CHIARI SYNDROME AND PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA

1981 • 40 citations

Paroxysmal Nocturnal Haemoglobinuria and Refractory Marrow Failure Treated by Marrow Transplantation

1973 • 39 citations

Production of In Vitro Lytic Characteristics of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes in Normal Erythrocytes

1968 • 39 citations

The erythrocyte acetylcholinesterase enzyme in paroxysmal nocturnal hemoglobinuria.

1960 • 38 citations

PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA IN PREGNANCY: CASE REPORT

1980 • 37 citations

Release of C8 binding protein (C8bp) from the cell membrane by phosphatidylinositol-specific phospholipase C

1988 • 37 citations

Differences in the terminal steps of complement lysis of normal and paroxysmal nocturnal hemoglobinuria red cells

1978 • 34 citations

Fulminant hepatic venous thrombosis (Budd-Chiari syndrome) in paroxysmal nocturnal hemoglobinuria: definition of a medical emergency.

1980 • 33 citations

The Effect of Iron Therapy in Paroxysmal Nocturnal Hemoglobinuria

1970 • 33 citations

Venous thrombosis and splenic rupture in paroxysmal nocturnal hemoglobinuria

1980 • 30 citations

Intestinal Infarction in Paroxysmal Nocturnal Hemoglobinuria

1966 • 29 citations

Blood Transfusion in Nocturnal Haemoglobinuria

1943 • 28 citations

Effect of Aspirin on the Complement System <i>in vitro</i>

1980 • 26 citations

Paroxysmal Nocturnal Haemoglobinuria

1984 • 26 citations

Hemolytic Anemias: Congenital and Acquired

1980 • 25 citations

Hemolytic anemias, congenital and acquired

1948 • 24 citations

Electron-Microscope Studies of the Red Cell in Paroxysmal Nocturnal Haemoglobinuria

1965 • 23 citations

Paroxysmal nocturnal hemoglobinuria and acute non-lymphocytic leukemia. A report of three cases exhibiting different cytologic types

1983 • 22 citations

Prospective hemostatic studies in a patient having paroxysmal nocturnal hemoglobinuria, pregnancy, and cerebral venous thrombosis

1982 • 22 citations

Intestinal infarction caused by paroxysmal nocturnal hemoglobinuria

1984 • 20 citations

Dural sinus thrombosis in paroxysmal nocturnal hemoglobinuria

1984 • 19 citations

Lysis of Paroxysmal Nocturnal Hemoglobinuria Erythrocytes by Acid-Activated Serum

1983 • 18 citations

Isolation and Characterization of a Factor from Human and Guinea Pig Serum That Accelerates the Decay of SAC142

1971 • 18 citations

Myelosclerosis and Paroxysmal Nocturnal Haemoglobinuria

1971 • 17 citations

Klinik und chirurgische Behandlung der Aortenisthmusstenose

1956 • 17 citations

PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA PARTURITION COMPLICATED BY PRESUMED HEPATIC VEIN THROMBOSIS

1968 • 16 citations

Thrombolyse beim Budd-Chiari-Syndrom infolge partieller Thrombose der Vena cava inferior und Lebervenen

1971 • 10 citations

Book Review

1972 • 8 citations

Paroxysmale nächtliche Hämoglobinurie (PNH) und Schwangerschaft*

1980 • 7 citations

In vivo stability of cryoprecipitate fibrinogen

1977 • 6 citations

Perioperative management of patients with paroxysmal nocturnal hemoglobinuria.

1981 • 6 citations

Enzymatic Activation of C3 by a Complex Derived from a Purified Cobra Venom Factor and a Serum Globulin

1971 • 5 citations

NORMAL KARYOTYPE IN SEVEN PATIENTS WITH PAROXYSMAL NOCTURNAL HAEMOGLOBINURIA

1982 • 5 citations

Knochenmarktransplantation im Erwachsenenalter bei akuter Leuk�mie, aplastischer An�mie und paroxysmaler n�chtlicher H�moglobinurie

1983 • 4 citations

Vascular problems in paroxysmal nocturnal haemoglobinuria

1982 • 4 citations