Does paracetamol (acetaminophen) reduce the pain of osteoarthritis?: a meta-analysis of randomised controlled trials

Meta-analysis in clinical trials

1986 • 36,193 citations

Assessing the quality of reports of randomized clinical trials: Is blinding necessary?

1996 • 17,261 citations

Aspirin plus Clopidogrel as Secondary Prevention after Stroke or Transient Ischemic Attack: A Systematic Review and Meta-Analysis

2014 • 11,326 citations

Efficacy and Safety of Tadalafil Monotherapy for Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Meta-Analysis

2013 • 4,441 citations

Improving the quality of reporting of randomized controlled trials. The CONSORT statement

1996 • 3,395 citations

The Cochrane Library

2005 • 2,069 citations

EULAR Recommendations 2003: an evidence based approach to the management of knee osteoarthritis: Report of a Task Force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

2003 • 2,055 citations

The number needed to treat: a clinically useful measure of treatment effect

1995 • 1,849 citations

The effects of specific medical conditions on the functional limitations of elders in the Framingham Study.

1994 • 1,576 citations

EULAR evidence based recommendations for the management of hand osteoarthritis: Report of a Task Force of the EULAR Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

2006 • 1,362 citations

Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care

2001 • 1,290 citations

A general parametric approach to the meta‐analysis of randomized clinical trials

1991 • 730 citations

Comparison of an Antiinflammatory Dose of Ibuprofen, an Analgesic Dose of Ibuprofen, and Acetaminophen in the Treatment of Patients with Osteoarthritis of the Knee

1991 • 633 citations

EULAR recommendations for the management of knee osteoarthritis: report of a task force of the Standing Committee for International Clinical Studies Including Therapeutic Trials (ESCISIT)

2000 • 564 citations

Relative Risk of Upper Gastrointestinal Complications among Users of Acetaminophen and Nonsteroidal Anti-Inflammatory Drugs

2001 • 302 citations

Comparison of naproxen and acetaminophen in a two‐year study of treatment of osteoarthritis of the knee

1993 • 264 citations

A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs.

2002 • 245 citations

Dose–response relationships between individual nonaspirin nonsteroidal anti‐inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta‐analysis based on individual patient data

2002 • 244 citations

A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee

2001 • 236 citations

Efficacy of Rofecoxib, Celecoxib, and Acetaminophen in Osteoarthritis of the Knee

2002 • 235 citations

Treatment of osteoarthritis pain with controlled release oxycodone or fixed combination oxycodone plus acetaminophen added to nonsteroidal antiinflammatory drugs: a double blind, randomized, multicenter, placebo controlled trial.

1999 • 219 citations

Lack of Efficacy of Acetaminophen in Treating Symptomatic Knee Osteoarthritis

2003 • 151 citations

n of 1 trials comparing a non-steroidal anti-inflammatory drug with paracetamol in osteoarthritis

1994 • 142 citations

Codeine plus paracetamol versus paracetamol in longer-term treatment of chronic pain due to osteoarthritis of the hip. A randomised, double-blind, multi-centre study

1990 • 125 citations

Fitting Continuous Models to Effect Size Data

1982 • 121 citations

Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic.

1992 • 110 citations

Tramadol/acetaminophen combination tablets for the treatment of osteoarthritis flare pain: a multicenter, outpatient, randomized, double-blind, placebo-controlled, parallel-group, add-on study

2002 • 107 citations

Determinants and sequelae associated with utilization of acetaminophen versus traditional nonsteroidal antiinflammatory drugs in an elderly population

2002 • 104 citations

Analgesic efficacy of paracetamol and its combination with codeine and caffeine in surgical pain-a meta-analysis

1996 • 84 citations

Key questions concerning paracetamol and NSAIDs for osteoarthritis

2002 • 57 citations

An endoscopic comparison of gastroduodenal injury with over-the-counter doses of ketoprofen and acetaminophen

1998 • 55 citations

An Endoscopic Comparison of Gastroduodenal Injury With Over-the-Counter Doses of Ketoprofen and Acetaminophen

1998 • 48 citations

Clinical Endoscopic Evaluation of the Gastroduodenal Tolerance to (R)‐ Ketoprofen, (R)‐ Flurbiprofen, Racemic Ketoprofen, and Paracetamol: A Randomized, Single‐Blind, Placebo‐Controlled Trial

1998 • 42 citations

Severity of knee pain does not predict a better response to an antiinflammatory dose of ibuprofen than to analgesic therapy in patients with osteoarthritis.

2001 • 40 citations

Analgesic efficacy of sustained release paracetamol in patients with osteoarthritis of the knee

2002 • 34 citations

Naproxen and paracetamol compared with naproxen only in coxarthrosis: Increased effect of the combination in 18 patients

1993 • 33 citations

Unexpected and pronounced antinociceptive synergy between spinal acetaminophen (paracetamol) and phentolamine

2001 • 24 citations

Acceptability and Efficacy of Two Associations of Paracetamol with a Central Analgesic (Dextropropoxyphene or Codeine): Comparison in Osteoarthritis

1992 • 24 citations

Comparison of a standard ibuprofen treatment regimen with a new ibuprofen/paracetamol/codeine combination in chronic osteo-arthritis.

1987 • 16 citations

[Endoscopic studies on the gastric tolerance of paracetamol and acetylsalicylic acid. A placebo-controlled, double-blind study in healthy volunteers].

1990 • 14 citations

Placebo-Controlled Study of the Analgesic Efficacy of a Paracetamol 500mg /Codeine 30mg Combination Together with Low-Dose vs High-Dose Diclofenac in Rheumatoid Arthritis

1999 • 11 citations

Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs. Franco-Belgian Task Force.

1997 • 11 citations

[Analgesic effect and clinical tolerability of the combination of paracetamol 500 mg and caffeine 50 mg versus paracetamol 400 mg and dextropropoxyphene 30 mg in back pain].

1996 • 11 citations

'Safapryn' and benorylate — a comparative trial of two new preparations of aspirin and paracetamol in the treatment of rheumatoid arthritis and osteoarthritis

1973 • 9 citations

Floctafenin versus acetaminophen for pain control in patients with osteoarthritis in the lower limbs

1997 • 7 citations

A method for comparing analgesics: glafenine and paracetamol. Multicenter cross-over approach.

1988 • 7 citations

Paracetamol plus metoclopramide (‘Paramax’) as an adjunct analgesic in the treatment of arthritis

1983 • 5 citations

Comparison in 141 outpatients with osteoarthritis of two combinations of paracetamol with a narcotic analgesic: a controlled clinical trial

1990 • 1 citations