Early rheumatoid arthritis: strategies for prevention and management

The PREMIER study: A multicenter, randomized, double‐blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment

2005 • 1,789 citations

Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial

2004 • 1,787 citations

Clinical and radiographic outcomes of four different treatment strategies in patients with early rheumatoid arthritis (the BeSt study): A randomized, controlled trial

2005 • 1,449 citations

A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

2005 • 1,444 citations

Effect of a treatment strategy of tight control for rheumatoid arthritis (the TICORA study): a single-blind randomised controlled trial

2004 • 1,389 citations

Radiographic, clinical, and functional outcomes of treatment with adalimumab (a human anti–tumor necrosis factor monoclonal antibody) in patients with active rheumatoid arthritis receiving concomitant methotrexate therapy: A randomized, placebo‐controlled, 52‐week trial

2004 • 1,180 citations

Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial

2004 • 1,165 citations

Preliminary criteria for clinical remission in rheumatoid arthritis

1981 • 806 citations

EULAR recommendations for the management of early arthritis: report of a task force of the European Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT)

2006 • 802 citations

Benefit of very early referral and very early therapy with disease-modifying anti-rheumatic drugs in patients with early rheumatoid arthritis

2004 • 788 citations

How to diagnose rheumatoid arthritis early: A prediction model for persistent (erosive) arthritis

2002 • 743 citations

Etanercept versus methotrexate in patients with early rheumatoid arthritis: Two‐year radiographic and clinical outcomes

2002 • 741 citations

COBRA combination therapy in patients with early rheumatoid arthritis: Long‐term structural benefits of a brief intervention

2002 • 615 citations

Early versus delayed treatment in patients with recent-onset rheumatoid arthritis: comparison of two cohorts who received different treatment strategies

2001 • 590 citations

Combination Therapy with Cyclosporine and Methotrexate in Severe Rheumatoid Arthritis

1995 • 530 citations

Factors predicting response to treatment in rheumatoid arthritis: The importance of disease duration

2000 • 490 citations

Low-Dose Prednisone Therapy for Patients with Early Active Rheumatoid Arthritis: Clinical Efficacy, Disease-Modifying Properties, and Side Effects: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

2002 • 481 citations

Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage

2003 • 462 citations

Early referral recommendation for newly diagnosed rheumatoid arthritis: evidence based development of a clinical guide

2002 • 423 citations

Bone edema scored on magnetic resonance imaging scans of the dominant carpus at presentation predicts radiographic joint damage of the hands and feet six years later in patients with rheumatoid arthritis

2003 • 421 citations

REMISSION IN A PROSPECTIVE STUDY OF PATIENTS WITH RHEUMATOID ARTHRITIS. AMERICAN RHEUMATISM ASSOCIATION PRELIMINARY REMISSION CRITERIA IN RELATION TO THE DISEASE ACTIVITY SCORE

1995 • 376 citations

Methotrexate in Rheumatoid Arthritis

1987 • 312 citations

Treatment with leflunomide slows radiographic progression of rheumatoid arthritis: Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis

2000 • 282 citations

Retardation of joint damage in patients with early rheumatoid arthritis by initial aggressive treatment with disease‐modifying antirheumatic drugs: Five‐year experience from the FIN‐RACo study

2004 • 281 citations

Prognostic factors for radiographic damage in early rheumatoid arthritis: A multiparameter prospective study

2001 • 278 citations

Combination therapy in early rheumatoid arthritis: a randomised, controlled, double blind 52 week clinical trial of sulphasalazine and methotrexate compared with the single components

1999 • 268 citations

The relationship between disease activity and radiologic progression in patients with rheumatoid arthritis: A longitudinal analysis

2004 • 266 citations

Patient education for adults with rheumatoid arthritis

2003 • 264 citations

Combination of sulphasalazine and methotrexate versus the single components in early rheumatoid arthritis: a randomized, controlled, double-blind, 52 week clinical trial

1997 • 242 citations

The assessment and prediction of functional disability in rheumatoid arthritis.

1991 • 236 citations

Methotrexate in rheumatoid arthritis. a five‐year prospective multicenter study

1994 • 227 citations

Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis

2000 • 215 citations

A vegan diet free of gluten improves the signs and symptoms of rheumatoid arthritis: the effects on arthritis correlate with a reduction in antibodies to food antigens

2001 • 201 citations

Meta‐analysis of treatment termination rates among rheumatoid arthritis patients receiving disease‐modifying anti‐rheumatic drugs

2000 • 185 citations

Magnetic resonance imaging of wrist and finger joints in healthy subjects occasionally shows changes resembling erosions and synovitis as seen in rheumatoid arthritis

2004 • 172 citations

Influence of disease‐modifying therapy on radiographic outcome in inflammatory polyarthritis at five years: Results from a large observational inception study

2003 • 169 citations

Occupational therapy for rheumatoid arthritis

2004 • 161 citations

Socio-economic consequences of rheumatoid arthritis in the first years of the disease.

1999 • 155 citations

Comparison of different definitions to classify remission and sustained remission: 1 year TEMPO results

2005 • 142 citations

Treatment of poor-prognosis early rheumatoid arthritis: A randomized study of treatment with methotrexate, cyclosporin A, and intraarticular corticosteroids compared with sulfasalazine alone

2000 • 135 citations

Ottawa Panel Evidence-Based Clinical Practice Guidelines for Therapeutic Exercises in the Management of Rheumatoid Arthritis in Adults

2004 • 122 citations

Work disability in an inception cohort of patients with seropositive rheumatoid arthritis: a 20 year study

1999 • 116 citations

Prognostic factors in a large cohort of patients with early undifferentiated inflammatory arthritis after application of a structured management protocol

2003 • 115 citations

Is it possible to predict radiological damage in early rheumatoid arthritis (RA)? A report on the occurrence, progression, and prognostic factors of radiological erosions over the first 3 years in 866 patients from the Early RA Study (ERAS).

2004 • 113 citations

Cyclosporin A monotherapy versus cyclosporin A and methotrexate combination therapy in patients with early rheumatoid arthritis: a double blind randomised placebo controlled trial

2003 • 110 citations

How to predict prognosis in early rheumatoid arthritis

2004 • 105 citations

Early diagnosis of rheumatoid arthritis

2004 • 103 citations

Short-term low-dose corticosteroids vs placebo and nonsteroidal antiinflammatory drugs in rheumatoid arthritis

2004 • 97 citations

Dynamic exercise therapy for treating rheumatoid arthritis

1998 • 82 citations

Outcomes for Persons With Rheumatoid Arthritis With a Rheumatologist Versus a Non-Rheumatologist as the Main Physician for This Condition

1998 • 73 citations

Criteria for early rheumatoid arthritis: From Bayes' law revisited to new thoughts on pathogenesis

2002 • 69 citations

Paracetamol versus nonsteroidal anti-inflammatory drugs for rheumatoid arthritis

2004 • 68 citations

Differences in the use of second-line agents and prednisone for treatment of rheumatoid arthritis by rheumatologists and non-rheumatologists.

1997 • 68 citations

Low dose prednisolone therapy (LDPT) retards radiographically detectable destruction in early rheumatoid arthritis –

2000 • 58 citations

Functional disability in early rheumatoid arthritis: description and risk factors.

1994 • 48 citations

Does early rheumatoid arthritis exist?

2004 • 38 citations

Should patients with recent-onset polyarthritis receive aggressive treatment?

2004 • 28 citations

Deleted Work

1955 • 0 citations

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