Prions as Protein-Based Genetic Elements

Prions

1998 • 5,102 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization

1998 • 4,811 citations

Getting started with yeast

2002 • 3,496 citations

[1] Getting started with yeast

1991 • 2,456 citations

Hsp104, Hsp70, and Hsp40

1998 • 1,346 citations

Prion Diseases of Humans and Animals: Their Causes and Molecular Basis

2001 • 1,307 citations

Role of the Chaperone Protein Hsp104 in Propagation of the Yeast Prion-Like Factor [ psi ⁺ ]

1995 • 1,036 citations

Nucleated Conformational Conversion and the Replication of Conformational Information by a Prion Determinant

2000 • 947 citations

Protein disaggregation mediated by heat-shock protein Hspl04

1994 • 861 citations

HSP104 Required for Induced Thermotolerance

1990 • 822 citations

Inhibition of actin polymerization by latrunculin A

1987 • 813 citations

A yeast prion provides a mechanism for genetic variation and phenotypic diversity

2000 • 686 citations

Support for the Prion Hypothesis for Inheritance of a Phenotypic Trait in Yeast

1996 • 620 citations

Self-Seeded Fibers Formed by Sup35, the Protein Determinant of [PSI+], a Heritable Prion-like Factor of S. cerevisiae

1997 • 604 citations

Prions Affect the Appearance of Other Prions

2001 • 573 citations

Hsp104 is required for tolerance to many forms of stress.

1992 • 546 citations

Genesis and Variability of [PSI] Prion Factors in Saccharomyces cerevisiae

1996 • 536 citations

A mutant of Saccharomyces cerevisiae defective for nuclear fusion.

1976 • 530 citations

Propagation of the yeast prion-like [psi+] determinant is mediated by oligomerization of the SUP35-encoded polypeptide chain release factor.

1996 • 512 citations

The translation machinery and 70 kd heat shock protein cooperate in protein synthesis

1992 • 512 citations

Molecular evolution of the HSP70 multigene family

1994 • 509 citations

Ψ, A cytoplasmic suppressor of super-suppressor in yeast

1965 • 508 citations

Rnq1

2000 • 508 citations

The products of the SUP45 (eRF1) and SUP35 genes interact to mediate translation termination in Saccharomyces cerevisiae.

1995 • 474 citations

Genetic and Environmental Factors Affecting the de novo Appearance of the [PSI + ] Prion in Saccharomyces cerevisiae

1997 • 459 citations

A census of glutamine/asparagine-rich regions: Implications for their conserved function and the prediction of novel prions

2000 • 458 citations

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog

1997 • 457 citations

A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor

1994 • 407 citations

The SUP35 omnipotent suppressor gene is involved in the maintenance of the non-Mendelian determinant [psi+] in the yeast Saccharomyces cerevisiae.

1994 • 386 citations

CYTOPLASMIC INHERITANCE OF THE ORGANIZATION OF THE CELL CORTEX IN PARAMECIUM AURELIA

1965 • 385 citations

An amyloid-forming peptide from the yeast prion Sup35 reveals a dehydrated β-sheet structure for amyloid

2001 • 376 citations

A Critical Role for Amino-Terminal Glutamine/Asparagine Repeats in the Formation and Propagation of a Yeast Prion

1998 • 369 citations

Complex Interactions Among Members of an Essential Subfamily of hsp70 Genes in Saccharomyces Cerevisiae

1987 • 358 citations

Molecular Genetics of Heterokaryon Incompatibility in Filamentous Ascomycetes

2000 • 357 citations

Prion-Inducing Domain of Yeast Ure2p and Protease Resistance of Ure2p in Prion-Containing Cells

1995 • 351 citations

Molecular Cloning of a Human Prion Protein cDNA

1986 • 337 citations

Biological Evidence that Scrapie Agent Has an Independent Genome

1987 • 320 citations

Non-Mendelian Mutation Allowing Ureidosuccinic Acid Uptake in Yeast

1971 • 316 citations

Multiple Gln/Asn-Rich Prion Domains Confer Susceptibility to Induction of the Yeast [PSI] Prion

2001 • 315 citations

Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments

1997 • 314 citations

AGENTS THAT CAUSE A HIGH FREQUENCY OF GENETIC CHANGE FROM [psi +] TO [psi -] IN SACCHAROMYCES CEREVISIAE

1981 • 303 citations

Deletion analysis of the SUP35 gene of the yeast Saccharomyces cerevisiae reveals two non‐overlapping functional regions in the encoded protein

1993 • 284 citations

Prion Domain Initiation of Amyloid Formation in Vitro from Native Ure2p

1999 • 278 citations

The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases.

1991 • 276 citations

Molecular Basis of a Yeast Prion Species Barrier

2000 • 275 citations

Regulation of Pyrimidine Biosynthesis in Saccharomyces cerevisiae

1968 • 272 citations

Prion biology and diseases.

1991 • 271 citations

[URE3] Prion Propagation in Saccharomyces cerevisiae: Requirement for Chaperone Hsp104 and Curing by Overexpressed Chaperone Ydj1p

2000 • 267 citations

Multicopy SUP35 gene induces de-novo appearance of psi-like factors in the yeast Saccharomyces cerevisiae

1993 • 266 citations

Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences

1988 • 262 citations

The role of ammonia metabolism in nitrogen catabolite repression inSaccharomyces cerevisiae

2000 • 255 citations

Double-stranded RNA viruses of Saccharomyces cerevisiae

1996 • 252 citations

Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression

2001 • 249 citations

Antagonistic Interactions between Yeast Chaperones Hsp104 and Hsp70 in Prion Curing

1999 • 245 citations

The elimination of the yeast [PSI⁺] prion by guanidine hydrochloride is the result of Hsp104 inactivation

2001 • 244 citations

Suppressors in Yeast

1974 • 242 citations

Conformational changes and disease — serpins, prions and Alzheimer's

1998 • 241 citations

Organelle Inheritance

1996 • 241 citations

Scrapie strain variation and mutation

1993 • 240 citations

Evidence for a Protein Mutator in Yeast: Role of the Hsp70-Related Chaperone Ssb in Formation, Stability, and Toxicity of the [PSI] Prion

1999 • 227 citations

Complex interactions among members of an essential subfamily of hsp70 genes in Saccharomyces cerevisiae.

1987 • 225 citations

The molecular chaperone Ssb from Saccharomyces cerevisiae is a component of the ribosome–nascent chain complex

1998 • 224 citations

Heat-shock protein 104 expression is sufficient for thermotolerance in yeast.

1996 • 223 citations

Guanidine Hydrochloride Inhibits Hsp104 Activity In Vivo: A Possible Explanation for Its Effect in Curing Yeast Prions

2001 • 221 citations

Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: coupling glucose sensing to gene expression and the cell cycle

1997 • 215 citations

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism

1999 • 213 citations

In Vitro Propagation of the Prion-Like State of Yeast Sup35 Protein

1997 • 210 citations

A Role for Cytosolic Hsp70 in Yeast [PSI+] Prion Propagation and [PSI+] as a Cellular Stress

2000 • 201 citations

The role of Sis1 in the maintenance of the [RNQ+] prion

2001 • 199 citations

Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins.

1991 • 198 citations

Mechanism of Prion Loss after Hsp104 Inactivation in Yeast

2001 • 196 citations

Dependence and independence of [PSI+] and [PIN+]: a two-prion system in yeast?

2000 • 195 citations

Evolutionary conservation of prion‐forming abilities of the yeast Sup35 protein

2000 • 194 citations

Yeast Hsp70 RNA levels vary in response to the physiological status of the cell

1989 • 193 citations

The [URE3] prion is an aggregated form of Ure2p that can be cured by overexpression of Ure2p fragments

1999 • 191 citations

The dominant PNM2- mutation which eliminates the psi factor of Saccharomyces cerevisiae is the result of a missense mutation in the SUP35 gene.

1994 • 189 citations

Guanidine hydrochloride blocks a critical step in the propagation of the prion-like determinant [ PSI ⁺ ] of Saccharomyces cerevisiae

2000 • 182 citations

The ψ factor of yeast: A problem in inheritance

1988 • 182 citations

Genetical aspects of [URE3], a non-mitochondrial, cytoplasmically inherited mutation in yeast

1975 • 177 citations

Nucleotide sequence of the SUP2 (SUP35) gene of Saccharomyces cerevisiae

1988 • 176 citations

Creating a Protein-Based Element of Inheritance

2000 • 176 citations

GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats.

1991 • 165 citations

The prion model for [URE3] of yeast: Spontaneous generation and requirements for propagation

1997 • 163 citations

Mad Cows Meet Psi-chotic Yeast: The Expansion of the Prion Hypothesis

1997 • 160 citations

Structure and Replication of Yeast Prions

1998 • 160 citations

Evidence for the Prion Hypothesis: Induction of the Yeast [ PSI ⁺ ] Factor by in Vitro- Converted Sup35 Protein

2000 • 155 citations

Induction of Distinct [URE3] Yeast Prion Strains

2001 • 155 citations

Prion properties of the Sup35 protein of yeast Pichia methanolica

2000 • 153 citations

The yeast SIS1 protein, a DnaJ homolog, is required for the initiation of translation

1993 • 150 citations

The Glycine-Phenylalanine-Rich Region Determines the Specificity of the Yeast Hsp40 Sis1

1999 • 147 citations

Chaperones that cure yeast artificial [PSI+] and their prion-specific effects

2000 • 146 citations

Strains of [PSI+] are distinguished by their efficiencies of prion-mediated conformational conversion

2001 • 144 citations

Conformational diversity in a yeast prion dictates its seeding specificity

2001 • 143 citations

Scrapie Strain Variation and Its Implications

1991 • 143 citations

The relationship between visible intracellular aggregates that appear after overexpression of Sup35 and the yeast prion‐like elements [PSI⁺] and [PIN⁺]

2001 • 137 citations

A Novel Membrane-bound Glutathione S-Transferase Functions in the Stationary Phase of the Yeast Saccharomyces cerevisiae

1998 • 129 citations

Structure of the Globular Region of the Prion Protein Ure2 from the Yeast Saccharomyces cerevisiae

2001 • 129 citations

Genetic Study of Interactions Between the Cytoskeletal Assembly Protein Sla1 and Prion-Forming Domain of the Release Factor Sup35 (eRF3) in Saccharomyces cerevisiae

1999 • 124 citations

Oligopeptide repeats in the yeast protein Sup35p stabilize intermolecular prion interactions

2001 • 124 citations

Improvement of Nitrogen Assimilation and Fermentation Kinetics under Enological Conditions by Derepression of Alternative Nitrogen-Assimilatory Pathways in an IndustrialSaccharomyces cerevisiaeStrain

1998 • 123 citations

The HET-s Prion Protein of the Filamentous Fungus Podospora anserina Aggregates in Vitro into Amyloid-like Fibrils

2002 • 122 citations

The yeast non-Mendelian factor [ETA+] is a variant of [PSI+], a prion-like form of release factor eRF3

1999 • 121 citations

Structural Characterization of Saccharomyces cerevisiae Prion-like Protein Ure2

1999 • 121 citations

A yeast gene required for the G1-to-S transition encodes a protein containing an A-kinase target site and GTPase domain.

1988 • 119 citations

SUF12 suppressor protein of yeast

1988 • 118 citations

Molecular chaperones: How J domains turn on Hsp70s

1999 • 113 citations

Supporting the structural basis of prion strains: induction and identification of [PSI] variants11Edited by F. E. Cohen

2001 • 113 citations

Yeast [PSI+] “Prions” that Are Crosstransmissible and Susceptible beyond a Species Barrier through a Quasi-Prion State

2001 • 111 citations

Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae

1996 • 109 citations

[PSI+]: An Epigenetic Modulator of Translation Termination Efficiency

1999 • 108 citations

Reversion analysis of [psi⁻] mutations inSaccharomyces cerevisiae

1981 • 105 citations

The role of conformational flexibility in prion propagation and maintenance for Sup35p.

2001 • 104 citations

Two Prion-Inducing Regions of Ure2p Are Nonoverlapping

1999 • 101 citations

Self-assembly properties of a model RING domain

2002 • 100 citations

The crystal structure of the nitrogen regulation fragment of the yeast prion protein Ure2p

2001 • 98 citations

Interaction between Yeast Sup45p (eRF1) and Sup35p (eRF3) Polypeptide Chain Release Factors: Implications for Prion-Dependent Regulation

1997 • 98 citations

Mutation processes at the protein level: is Lamarck back?

2001 • 94 citations

Interactions of the chaperone Hsp104 with yeast Sup35 and mammalian PrP

1997 • 90 citations

Yeast mutants pleiotropically impaired in the regulation of the two glutamate dehydrogenases

1973 • 90 citations

Novel Non-Mendelian Determinant Involved in the Control of Translation Accuracy in Saccharomyces cerevisiae

2002 • 89 citations

Increased Rates of Genomic Deletions Generated by Mutations in the Yeast Gene Encoding DNA Polymerase δ or by Decreases in the Cellular Levels of DNA Polymerase δ

2000 • 86 citations

Ion Tolerance of Saccharomyces cerevisiae Lacking the Ca2+/CaM-Dependent Phosphatase (Calcineurin) Is Improved by Mutations in URE2 or PMA1

1998 • 83 citations

Yeast prion protein derivative defective in aggregate shearing and production of new seeds'

2001 • 83 citations

The C‐terminus of eRF1 defines a functionally important domain for translation termination inSaccharomyces cerevisiae

1999 • 82 citations

Equilibrium folding properties of the yeast prion protein determinant Ure2 1 1Edited by J. Karn

1999 • 82 citations

Divide and multiply: organelle partitioning in yeast

2000 • 82 citations

Gln3p Nuclear Localization and Interaction with Ure2p inSaccharomyces cerevisiae

2001 • 82 citations

Multigenerational Cortical Inheritance of the Rax2 Protein in Orienting Polarity and Division in Yeast

2000 • 82 citations

Prions of Yeast and Fungi

1999 • 80 citations

Stability, Folding, Dimerization, and Assembly Properties of the Yeast Prion Ure2p

2001 • 80 citations

Prion Filament Networks in [Ure3] Cells of Saccharomyces cerevisiae

2001 • 80 citations

Two allelic genes responsible for vegetative incompatibility in the fungus Podospora anserina are not essential for cell viability

1991 • 76 citations

Mutation of the non-Mendelian suppressor, Ψ ⁺ , in yeast by hypertonic media

1979 • 74 citations

Transmissible spongiform encephalopathies, amyloidoses and yeast prions: Common threads?

2000 • 72 citations

[PSI⁺] prion generation in yeast: characterization of the ‘strain’ difference

2001 • 65 citations

In vivo aggregation of the HET‐s prion protein of the fungus Podospora anserina

2001 • 63 citations

Extrachromosomal elements in a super-suppression system of yeast I. A nuclear gene controlling the inheritance of the extrachromosomal elements

1971 • 63 citations

Propagation of a Novel Cytoplasmic, Infectious and Deleterious Determinant Is Controlled by Translational Accuracy in Podospora anserina

1999 • 61 citations

C-terminal truncation of the Sup35 protein increases the frequency of de novo generation of a prion-based [ PSI + ] determinant in Saccharomyces cerevisiae

1998 • 60 citations

Overexpression of theSUP45gene encoding a Sup35p-binding protein inhibits the induction of thede novoappearance of the[PSI⁺]prion

1998 • 59 citations

What makes homologous chromosomes find each other in meiosis? A review and an hypothesis

1999 • 59 citations

The prion domain of yeast Ure2P induces autocatalytic formation of amyloid fibers by a recombinant fusion protein

2000 • 58 citations

Interactions and conversions of prion protein isoforms

2001 • 57 citations

Molecular Population Genetics and Evolution of a Prion-like Protein in Saccharomyces cerevisiae

2001 • 57 citations

The yeast prion [URE3] can be greatly induced by a functional mutated URE2 allele

2000 • 57 citations

The Utility of Prions

2002 • 55 citations

Mks1p Is a Regulator of Nitrogen Catabolism Upstream of Ure2p in Saccharomyces cerevisiae

1999 • 53 citations

The PNM2 mutation in the prion protein domain of SUP35 has distinct effects on different variants of the [ PSI + ] prion in yeast

1999 • 53 citations

The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae

2000 • 51 citations

A protein required for prion generation: [URE3] induction requires the Ras-regulated Mks1 protein

2000 • 48 citations

SSB , Encoding a Ribosome-Associated Chaperone, Is Coordinately Regulated with Ribosomal Protein Genes

1999 • 46 citations

An Antiprion Effect of the Anticytoskeletal Drug Latrunculin A in Yeast

2001 • 45 citations

Expression of members of the Saccharomyces cerevisiae hsp70 multigene family

1989 • 45 citations

pet 18: A chromosomal gene required for cell growth and for the maintenance of mitochondrial DNA and the killer plasmid of yeast

1978 • 44 citations

Mutational Analysis of the [Het-s] Prion Analog of Podospora anserina: A Short N-Terminal Peptide Allows Prion Propagation

1999 • 43 citations

A non-Mendelian factor, [eta+], causes lethality of yeast omnipotent-suppressor strains

1984 • 43 citations

New cytoplasmic genetic element that controls 20S RNA synthesis during sporulation in yeast

1978 • 41 citations

REVERSION FROM SUPPRESSION TO NONSUPPRESSION IN SUQ5 [psi +] STRAINS OF YEAST: THE CLASSIFICATION OF MUTATIONS

1980 • 40 citations

Folding of the yeast prion protein Ure2: kinetic evidence for folding and unfolding intermediates 1 1Edited by J. Karn

2002 • 39 citations

Complex Multigene Family of Functionally Distinct Hsp70s of Yeast

1995 • 38 citations

Extrachromosomal elements in a super-suppression system of yeast II. Relations with other extrachromosomal elements

1972 • 32 citations

GLUCOSAMINE RESISTANCE IN YEAST. I. A PRELIMINARY GENETIC ANALYSIS

1976 • 32 citations

Glucosamine resistance in yeast

1977 • 31 citations

Non-conventional infectious elements in filamentous fungi

1999 • 30 citations

MUTANTS OF THE KILLER PLASMID OF SACCHAROMYCES CEREVISIAE DEPENDENT ON CHROMOSOMAL DIPLOIDY FOR EXPRESSION AND MAINTENANCE

1976 • 28 citations

Relationship of the [psi] factor with other plasmids of Saccharomyces cerevisiae

1982 • 27 citations

Shared control of maltose induction and catabolite repression of the MAL structural genes in Saccharomyces

1994 • 27 citations

Cytoplasmic mutations isolated from protoplasts ofPodospora anserina

1975 • 26 citations

The [URE3] phenotype: evidence for a soluble prion in yeast

2002 • 25 citations

Extrachromosomal elements in a super-suppression system of yeast

1975 • 22 citations

Localization of possible functional domains in sup2 gene product of the yeast Saccharomyces cerevisiae

1987 • 21 citations

13 Regulation and Function of the HSP70 Multigene Family of Saccharomyces cerevisiae

1990 • 18 citations

The crystal structure of the nitrogen regulation fragment of the yeast prion protein Ure2p

2001 • 18 citations

6 Prions of Fungi: [URE3], [PSI], and [Het-s] Discovered as Heritable Traits

1999 • 16 citations

The [KIL-d] Cytoplasmic Genetic Element of Yeast Results in Epigenetic Regulation of Viral M Double-Stranded RNA Gene Expression

1998 • 16 citations

Targeting protein inactivation through an oligomerization chain reaction

2002 • 16 citations

The [KIL-d] Element Specifically Regulates Viral Gene Expression in Yeast

2000 • 13 citations

[Nonsense-suppression during amplification of the gene coding for protein translation factor].

1988 • 11 citations

[Deletion analysis of the SUP2 gene in Saccharomyces cerevisiae].

1990 • 6 citations

A new mitochondrial mutation in saccharomyces cerevisiae

1975 • 5 citations

THE ROLE OF HSP104 IN STRESS TOLERANCE AND PRION MAINTENANCE

1999 • 5 citations

[Comparative analysis of the structure of SUP2 genes in Pichia pinus and Saccharomyces cerevisiae].

1990 • 4 citations

[Characteristics of transcripts of sup1 and sup2 genes in Saccharomyces yeasts].

1986 • 2 citations