Murine epidermal Langerhans cells and splenic dendritic cells present tumor‐associated antigens to primed T cells

Murine epidermal Langerhans cells mature into potent immunostimulatory dendritic cells in vitro.

1985 • 1,141 citations

Epidermal Langerhans cells are derived from cells originating in bone marrow

1979 • 879 citations

Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization.

1990 • 543 citations

The Regulatory Role of Macrophages in Antigenic Stimulation Part Two: Symbiotic Relationship between Lymphocytes and Macrophages

1981 • 518 citations

Origin and Function of Epidermal Langerhans Cells

1980 • 406 citations

Interferon gamma and tumor necrosis factor have a role in tumor regressions mediated by murine CD8+ tumor-infiltrating lymphocytes.

1991 • 402 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells.

1985 • 295 citations

Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.

1991 • 283 citations

Studies in a tumor spectrum. III. The effect of phosphoramides on the growth of a variety of mouse and rat tumors.

1955 • 252 citations

Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes.

1986 • 238 citations

Phenotypic and functional characteristics of in vivo-activated Langerhans cells.

1990 • 238 citations

Regulation of macrophage populations. I. Preferential induction of Ia-rich peritoneal exudates by immunologic stimuli.

1980 • 231 citations

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo.

1992 • 215 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

Dendritic cells stimulate primary human cytolytic lymphocyte responses in the absence of CD4+ helper T cells.

1990 • 210 citations

Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins.

1990 • 193 citations

Ia Antigens in Mouse Skin Are Predominantly Expressed on Langerhans Cells

1979 • 185 citations

The role of tumor-specific Lyt-1+2- T cells in eradicating tumor cells in vivo. I. Lyt-1+2- T cells do not necessarily require recruitment of host's cytotoxic T cell precursors for implementation of in vivo immunity.

1984 • 156 citations

Enhanced antigen-presenting capacity of cultured Langerhans' cells is associated with markedly increased expression of Ia antigen.

1987 • 154 citations

Antitumor efficacy of lymphokine-activated killer cells and recombinant interleukin 2 in vivo: successful immunotherapy of established pulmonary metastases from weakly immunogenic and nonimmunogenic murine tumors of three district histological types.

1986 • 149 citations

Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells.

1991 • 148 citations

Unique murine tumor-associated antigens identified by tumor infiltrating lymphocytes.

1990 • 139 citations

Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor.

1990 • 127 citations

CD8+ T cell homing to the pancreas in the nonobese diabetic mouse is CD4+ T cell-dependent.

1991 • 108 citations

Evidence that the local effect of ultraviolet radiation on the growth of murine melanomas is immunologically mediated.

1991 • 103 citations

Functional significance of the regulation of macrophage Ia expression

1984 • 101 citations

Requirement for recognition of class II molecules and processed tumor antigen for optimal generation of syngeneic tumor-specific class I-restricted CTL.

1986 • 97 citations

Activation and expansion of hapten- and protein-specific T helper cells from nonsensitized mice.

1988 • 93 citations

Freshly isolated spleen dendritic cells and epidermal Langerhans cells undergo similar phenotypic and functional changes during short-term culture.

1990 • 90 citations

CD4+ T cell clones specific for the human p97 melanoma-associated antigen can eradicate pulmonary metastases from a murine tumor expressing the p97 antigen.

1991 • 86 citations

Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.

1988 • 71 citations

Epidermal Cell-Induced Generation of Cytotoxic T-Lymphocyte Responses Against Alloantigens or TNP-Modified Syngeneic Cells: Requirement for Ia-Positive Langerhans Cells

1983 • 62 citations

Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.

1989 • 57 citations

Adoptive immunotherapy of a newly induced sarcoma: immunologic characteristics of effector cells.

1985 • 57 citations

Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen.

1985 • 44 citations

Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.

1990 • 42 citations

Dendritic Cell Production of Cytokines and Responses to Cytokines

1990 • 27 citations

Characterization of variant and parental-cross-protective immunity to immunogenic variants of a murine fibrosarcoma using the local adoptive transfer assay

1989 • 2 citations