Metabolic inhibitors and subcellular distribution of GABA

Determination of protein: A modification of the lowry method that gives a linear photometric response

1972 • 5,490 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Handbook of Neurochemistry

1969 • 940 citations

Synaptic plasma membranes from rat brain synaptosomes: Isolation and partial characterization

1971 • 634 citations

GABA in nervous system function

1976 • 529 citations

GABA in Nervous System Function

1977 • 503 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

Enzyme-Activated Irreversible Inhibitors

1979 • 420 citations

EFFECTS OF DI‐n‐PROPYLACETATE, AN ANTICONVULSIVE COMPOUND, ON GABA METABOLISM¹

1969 • 394 citations

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

1977 • 375 citations

Sodium Valproate

1977 • 318 citations

Effect of sodium n-dipropylacetate on audiogenic seizures and brain γ-aminobutyric acid level

1973 • 285 citations

Glutamate and γ-Aminobutyric Acid in Brain

1970 • 269 citations

THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

1977 • 216 citations

Audiogenic seizure protection by elevated brain GABA concentration in mice: Effects of γ-acetylenic GABA and γ-vinyl GABA, two irreversible GABA-T inhibitors

1977 • 203 citations

PROPERTIES OF BRAIN <scp>l</scp>‐GLUTAMATE DECARBOXYLASE: INHIBITION STUDIES¹

1974 • 186 citations

Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures

1976 • 175 citations

Effect of the convulsive agent 3-mercaptopropionic acid on the levels of GABA, other amino acids and glutamate decarboxylase in different regions of the rat brain

1974 • 173 citations

Elevation of γ-aminobutyric acid in brain with amino-oxyacetic acid and susceptibility to convulsive seizures in mice: A quantitative re-evaluation

1966 • 166 citations

Evidence for an involvement of GABA in the mediation of the cerebellar cGMP decrease and the anticonvulsant action of diazepam

1975 • 144 citations

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1975 • 136 citations

Monoamine and GABA metabolism and the anticonvulsant action of DI-n-propylacetate and ethanolamine-O-sulphate

1977 • 113 citations

The inhibitory effect of sodium n‐dipropyl acetate on the degradative enzymes of the GABA shunt

1975 • 112 citations

Effect of n‐dipropylacetate on amino acid concentrations in mouse brain: correlations with anti‐convulsant activity

1978 • 108 citations

Effects of Anticonvulsant Drugs on the Cerebral Enzymes Metabolizing GABA

1975 • 105 citations

On the relationship of brain gamma-aminobutyric acid to convulsions.

1962 • 103 citations

Genetics of audiogenic seizures: II. Effects of pharmacological manipulation of brain serotonin, norepinephrine and -aminobutyric acid

1968 • 99 citations

Enzyme-activated irreversible inhibitors of L-ornithine:2-oxoacid aminotransferase. Demonstration of mechanistic features of the inhibition of ornithine aminotransferase by 4-aminohex-5-ynoic acid and gabaculine and correlation with in vivo activity.

1978 • 97 citations

Anticonvulsant properties of amino-oxyacetic acid

1961 • 73 citations

Regiospecific 1,4 addition of a propargylic anion. A general synthon for 2-substituted propargylamines as potential catalytic irreversible enzyme inhibitors.

1975 • 73 citations

THE ANTICONVULSANT ACTION OF GABA‐ELEVATING AGENTS: A RE‐EVALUATION

1975 • 73 citations

A Method for the Determination of Some Amino Acid Decarboxylases

1960 • 71 citations

The in vivo effects of hydrazines and vitamin B6 on the metabolism of gamma-aminobutyric acid.

1963 • 69 citations

Antiseizure activity of gamma-acetylenic gamma-aminobutyric acid: a catalytic irreversible inhibitor of gamma-aminobutyric acid transaminase.

1977 • 68 citations

THE EFFECT OF THE CONVULSANT 3‐MERCAPTOPROPIONIC ACID ON ENZYMES OF THE γ‐AMINO‐BUTYRATE SYSTEM IN THE RAT CEREBRAL CORTEX

1973 • 62 citations

Aminooxyacetic acid induced changes in γ-aminobutyrate metabolism at the subcellular level

1978 • 61 citations

DEVELOPMENT OF AN EXPRESSION WHICH RELATES THE EXCITABLE STATE OF THE BRAIN TO THE LEVEL OF GAD ACTIVITY AND GABA CONTENT, WITH PARTICULAR REFERENCE TO THE ACTION OF HYDRAZINE AND ITS DERIVATIVES

1974 • 58 citations

REGIONAL CHANGES IN CEREBRAL GABA CONCENTRATION AND CONVULSIONS PRODUCED BY <scp>d</scp> AND BY <scp>l</scp>‐ALLYLGLYCINE

1978 • 50 citations

Free amino acids and glutamate decarboxylase activity in brain of mice during drug-induced convulsions

1967 • 50 citations

A LIGHT‐SCATTERING TECHNIQUE FOR THE STUDY OF THE PERMEABILITY OF RAT BRAIN SYNAPTOSOMES IN VITRO

1970 • 45 citations

PREPARATION OF SYNAPTOSOMES AND VESICLES WITH SODIUM DIATRIZOATE¹

1974 • 45 citations

Association of putrescine, spermidine, spermine, and GABA with structural elements of brain cells

1976 • 43 citations

Modifications of brain glutamate decarboxylase activity by pyridoxal phosphate-γ-glutamyl hydrazone

1967 • 38 citations

Attempts to Correlate Alterations in Brain GABA Metabolism by GABA-T Inhibitors with Their Anticonvulsant Effects

1979 • 35 citations

γ-Acid Metabolism in Subcellular Particles of Mouse Brain and Its Relationship to Convulsions

1977 • 34 citations

Effect of di-n-propylacetate and ?-acetylenic GABA on hyperbaric oxygen-induced seizures and GABA metabolism

1977 • 22 citations

Determination of serotonin in tissues using an ion-exchange resin

1964 • 21 citations

Field desorption mass spectrometry of carboxylate salts: characteristic spectra and effects of added complexing agents

1978 • 21 citations

A routine assay procedure for monoamine oxidase and its application to human blood platelets

1976 • 19 citations

Anticonvulsant Properties of Hydroxylamine and Elevation of Cerebral -Aminobutyric Acid in Cats.

1959 • 18 citations

Rapid method for the assay of 4-aminobutyric acid (GABA), glutamic acid and aspartic acid in brain tissue and subcellular fractions

1979 • 15 citations

Purification of l-glutamate decarboxylase by affinity chromatography

1977 • 14 citations

A Correlation between Changes in γAminobutyric Acid Metabolism and Seizures Induced by Antivitamin B6

1976 • 8 citations