Differential binding and biological activities of epidermal growth factor and transforming growth factor alpha in a human pancreatic cancer cell line.

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

GROWTH FACTOR RECEPTOR TYROSINE KINASES

1988 • 1,841 citations

RECEPTORS FOR EPIDERMAL GROWTH FACTOR AND OTHER POLYPEPTIDE MITOGENS

1987 • 1,274 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Studies of Inositol Phospholipid-Specific Phospholipase C

1989 • 914 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

Overexpression of TGFα in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast

1990 • 753 citations

TGFα overexpression in transgenic mice induces liver neoplasia and abnormal development of the mammary gland and pancreas

1990 • 714 citations

Cell migration is essential for sustained growth of keratinocyte colonies: The roles of transforming growth factor-α and epidermal growth factor

1987 • 703 citations

Nerve growth factor receptors on human melanoma cells in culture.

1977 • 670 citations

Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor

1987 • 609 citations

Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family

1989 • 586 citations

Overexpression of Transforming Growth Factor α in Psoriatic Epidermis

1989 • 537 citations

Journey to the Center of the Cell: Role of the Receptosome

1981 • 500 citations

Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing

1987 • 479 citations

Epidermal growth factor stimulates tyrosine phosphorylation of phospholipase C-II independently of receptor internalization and extracellular calcium.

1989 • 402 citations

Epithelial Wound Healing Enhanced by Transforming Growth Factor-α and Vaccinia Growth Factor

1987 • 368 citations

Down-regulation of the epidermal growth factor receptor in KB cells is due to receptor internalization and subsequent degradation in lysosomes.

1984 • 295 citations

Epidermal growth factor-like transforming growth factor. I. Isolation, chemical characterization, and potentiation by other transforming factors from feline sarcoma virus-transformed rat cells.

1983 • 266 citations

Ligand-induced endocytosis of the EGF receptor is blocked by mutational inactivation and by microinjection of anti-phosphotyrosine antibodies

1988 • 248 citations

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle.

1987 • 230 citations

Characterization and cDNA cloning of phospholipase C-gamma, a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase.

1990 • 195 citations

Enhanced expression of epidermal growth factor receptor correlates with alterations of chromosome 7 in human pancreatic cancer.

1986 • 192 citations

Growth factors: The epidermal growth factor receptor gene and its product

1984 • 187 citations

A mutant epidermal growth factor receptor with defective protein tyrosine kinase is unable to stimulate proto-oncogene expression and DNA synthesis.

1987 • 186 citations

A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues

1989 • 164 citations

[17] Identification of receptor for type-β transforming growth factor

1987 • 134 citations

Epidermal growth factor and transforming growth factor .alpha. bind differently to the epidermal growth factor receptor

1989 • 130 citations

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling.

1988 • 119 citations

The genome of Shope fibroma virus, a tumorigenic poxvirus, contains a growth factor gene with sequence similarity to those encoding epidermal growth factor and transforming growth factor alpha.

1987 • 115 citations

Epidermal growth factor receptor threonine and serine residues phosphorylated in vivo.

1988 • 112 citations

Distinct vascular actions of epidermal growth factor-urogastrone and transforming growth factor-alpha.

1987 • 82 citations

The purification of fully active recombinant transforming growth factor alpha produced in Escherichia coli.

1986 • 68 citations

Divergent effects of epidermal growth factor and transforming growth factors on a human endometrial carcinoma cell line.

1987 • 63 citations

Detection of human lung epithelial cell growth factors produced by a lung carcinoma cell line: use in culture of primary solid lung tumors.

1987 • 60 citations

Attenuated Processing of Epidermal Growth Factor in the Face of Marked Degradation of Transforming Growth Factor-α

1989 • 56 citations

Biosynthesis and metabolic degradation of receptors for epidermal growth factor

1986 • 47 citations

Human epidermal growth factor receptor residue covalently cross-linked to epidermal growth factor.

1990 • 43 citations

Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha.

1986 • 37 citations

Regulation of Transforming Growth Factor-α mRNA Expression in T3M4 Human Pancreatic Carcinoma Cells

1991 • 27 citations

Characterization of site-specific antibodies to the erbB gene product and EGF receptor: Inhibition of tyrosine kinase activity

1986 • 14 citations