Correction of adenosine deaminase deficiency in cultured human T and B cells by retrovirus-mediated gene transfer.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Isolation of High‐Molecular‐Weight DNA from Mammalian Cells

1973 • 1,723 citations

ADENOSINE-DEAMINASE DEFICIENCY IN TWO PATIENTS WITH SEVERELY IMPAIRED CELLULAR IMMUNITY

1972 • 1,654 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

Introduction of a selectable gene into primitive stem cells capable of long-term reconstitution of the hemopoietic system of W/W mice

1985 • 663 citations

Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors

1985 • 598 citations

Prospects for Human Gene Therapy

1984 • 548 citations

Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse

1984 • 527 citations

The Role of Adenosine and 2'-Deoxyadenosine in Mammalian Cells

1978 • 518 citations

Deoxyadenosine triphosphate as a potentially toxic metabolite in adenosine deaminase deficiency.

1978 • 399 citations

Tight-binding inhibitors—IV. Inhibition of adenosine deaminases by various inhibitors

1977 • 376 citations

Gene Expression in Mice After High Efficiency Retroviral-Mediated Gene Transfer

1985 • 281 citations

Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

1978 • 277 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

Enzyme Replacement Therapy for Adenosine Deaminase Deficiency and Severe Combined Immunodeficiency

1976 • 249 citations

Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells

1983 • 214 citations

A transmissible retrovirus expressing human hypoxanthine phosphoribosyltransferase (HPRT): gene transfer into cells obtained from humans deficient in HPRT.

1983 • 208 citations

Expression of a Retrovirus Encoding Human HPRT in Mice

1984 • 182 citations

Adenosine deaminase deficiency: Frequency and comparative pathology in autosomally recessive severe combined immunodeficiency

1979 • 87 citations

Retroviral Vector-Mediated Gene Transfer into Human Hematopoietic Progenitor Cells

1985 • 83 citations

Characterization of the residual adenosine deaminating activity in the spleen of a patient with combined immunodeficiency disease and adenosine deaminase deficiency

1978 • 66 citations

Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines.

1984 • 60 citations

Transformation and Cytopathogenic Effect in an Immune Human T-Cell Clone Infected by HTLV-I

1984 • 49 citations

Expression of human adenosine deaminase using a transmissable murine retrovirus vector system.

1985 • 36 citations

Biochemical and Functional Abnormalities in Lymphocytes from an Adenosine Deaminase-deficient Patient during Enzyme Replacement Therapy

1981 • 33 citations

A micromethod for determining adenosine deaminase and purine nucleoside phosphorylase activity in cells from human peripheral blood

1978 • 31 citations

Characteristics of an aminohydrolase distinct from adenosine deaminase in cultured human lymphoblasts

1981 • 27 citations

Differential inhibition of adenosine deaminase deficient peripheral blood lymphocytes and lymphoid line cells by deoxyadenosine and adenosine

1979 • 26 citations

Structure of Adenosine Deaminase mRNAs From Normal and Adenosine Deaminase-Deficient Human Cell Lines

1984 • 25 citations

Immunological and biochemical profiles in response to transfusion therapy in an adenosine deaminase-deficient patient with severe combined immunodeficiency disease

1979 • 24 citations

Characterization of normal and mutant adenosine deaminase messenger RNAs by translation and hybridization to a cDNA probe

1984 • 15 citations